Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MCM5_HUMAN
Description:minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:6948]
Location:chr22 q12.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y403SPIGVyTSGKGMCMPhosphoSitePlus
S605SDRRSsIPITVMCMPhosphoSitePlus
S604DSDRRsSIPITMCMPhosphoSitePlus
S159IIIAAsAVRAKPhosphoSitePlus; HPRD
S2FDDPHPRD
Y212CPLDPyFIMPDPhosphoSitePlus
S424MRDPSsRNFIMMCMPhosphoSitePlus
Y269TIMGIySIKKFPhosphoSitePlus
S423VMRDPsSRNFIMCMPhosphoSitePlus
Y248RHMQLyCDRYLPhosphoSitePlus
S2____MsGFDDPPhosphoSitePlus
S130QVMLKsDASPSHPRD
Y332ALPNVyEVISKMCMPhosphoSitePlus

Dephosphorylation site
MCM5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000216122V568LTCGAOvarian Cancer21720365, 18772890
ENSP00000216122V568LCOSMICOvarian Cancer21720365
ENSP00000216122D438NCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000216122Gastric CancerMetastasiscell lineDown0.5817022644
ENSP00000216122Gastric CancerMetastasiscell lineDown0.5817022644
ENSP00000216122Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
MCM5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ACVR1_HUMANMCM5_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MCM5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0042555MCM complexIDAcellular_component
GO:0006270DNA replication initiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0004386helicase activityIEAmolecular_function
GO:0006260DNA replicationIEAbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process


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