| UniProt/SwissProt ID: | MCM5_HUMAN |
| Description: | minichromosome maintenance complex component 5 [Source:HGNC Symbol;Acc:6948] |
| Location: | chr22 q12.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y403 | SPIGVyTSGKG | MCM | PhosphoSitePlus |
| S605 | SDRRSsIPITV | MCM | PhosphoSitePlus |
| S604 | DSDRRsSIPIT | MCM | PhosphoSitePlus |
| S159 | IIIAAsAVRAK | PhosphoSitePlus; HPRD | |
| S2 | FDDP | HPRD | |
| Y212 | CPLDPyFIMPD | PhosphoSitePlus | |
| S424 | MRDPSsRNFIM | MCM | PhosphoSitePlus |
| Y269 | TIMGIySIKKF | PhosphoSitePlus | |
| S423 | VMRDPsSRNFI | MCM | PhosphoSitePlus |
| Y248 | RHMQLyCDRYL | PhosphoSitePlus | |
| S2 | ____MsGFDDP | PhosphoSitePlus | |
| S130 | QVMLKsDASPS | HPRD | |
| Y332 | ALPNVyEVISK | MCM | PhosphoSitePlus |
| Dephosphorylation site |
| MCM5_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000216122 | V568L | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000216122 | V568L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000216122 | D438N | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000216122 | Gastric Cancer | Metastasis | cell line | Down | 0.58 | 17022644 | ENSP00000216122 | Gastric Cancer | Metastasis | cell line | Down | 0.58 | 17022644 | ENSP00000216122 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| MCM5_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ACVR1_HUMAN | MCM5_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| MCM5_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0042555 | MCM complex | IDA | cellular_component |
| GO:0006270 | DNA replication initiation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006271 | DNA strand elongation involved in DNA replication | TAS | biological_process |
| GO:0004386 | helicase activity | IEA | molecular_function |
| GO:0006260 | DNA replication | IEA | biological_process |
| GO:0000084 | S phase of mitotic cell cycle | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0000082 | G1/S transition of mitotic cell cycle | TAS | biological_process |
| GO:0000216 | M/G1 transition of mitotic cell cycle | TAS | biological_process |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |