| UniProt/SwissProt ID: | PTPRR_HUMAN |
| Description: | protein tyrosine phosphatase, receptor type, R [Source:HGNC Symbol;Acc:9680] |
| Location: | chr12 q15 |
| Node attribute: | substrate; phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T440 | RPKNVtDSLST | Y_phosphatase | PhosphoSitePlus |
| Y504 | EKCVLyWPEKR | Y_phosphatase | PhosphoSitePlus |
| Y44 | KPVFIyKHSQD | PhosphoSitePlus | |
| S430 | LPNPLsRVCLR | Y_phosphatase | PhosphoSitePlus |
| Y62 | APQKIyRHSYH | PhosphoSitePlus | |
| S342 | RGSNVsLTLDM | PhosphoSitePlus | |
| T361 | FVSIPtPREKV | PhosphoSitePlus | |
| Y125 | KVAMEyLQSAS | HPRD | |
| T361 | FVSIPtPREKV | MAPK3 | HPRD |
| Y370 | KVAMEyLQSAS | PhosphoSitePlus; HPRD; phosphoELM | |
| S358 | IEPFVsIPTPR | PhosphoSitePlus | |
| S339 | QERRGsNVSLT | PKACa | RegPhos |
| S94 | QERRGsNVSLT | PRKACA | HPRD |
| T361 | FVSIPtPREKV | Erk1 | RegPhos |
| T361 | FVSIPtPREKV | Erk2 | RegPhos |
| S339 | QERRGsNVSLT | PRKACA | HPRD |
| S456 | YIRGYsGKEKA | Y_phosphatase | PhosphoSitePlus |
| T116 | FVSIPtPREKV | MAPK3 | HPRD |
| T116 | FVSIPtPREKV | MAPK1 | HPRD |
| S339 | QERRGsNVSLT | PKA_group | RegPhos |
| T361 | FVSIPtPREKV | MAPK1 | HPRD |
| Dephosphorylation site |
| PTPRR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000283228 | T541A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000283228 | N190S | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000283228 | S389N | COSMIC | Skin Cancer | 21984974 | ENSP00000283228 | E409K | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| PTPRR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTPRR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | PTPRR_HUMAN | kinase -> substrate | HPRD |
| MK01_HUMAN | PTPRR_HUMAN | kinase -> substrate | HPRD |
| MK03_HUMAN | PTPRR_HUMAN | kinase -> substrate | HPRD |
| PTPRR_HUMAN | MK07_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEP | biological_process |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatas | TAS | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | IEA | biological_process |
| GO:0009986 | cell surface | IDA | cellular_component |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |