Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CSK2B_HUMAN
Description:casein kinase 2, beta polypeptide [Source:HGNC Symbol;Acc:2460]
Location:chrHSCHR6_MHC_QBL p2
Node attribute:substrate; kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S2SEEVCK2_groupphosphoELM
S205QLQAAsNFKSPHPRD
S2SEEVphosphoELM
S4MSSSEeVSWRegPhos
S69DNPNQsDLIEQHPRD; SysPTM
S2MSSSEeVautocatalysisRegPhos
S3MSSSEeVSCK2 betaRegPhos
S3MSSSEeVSRegPhos
S11EVSWIsWFCGLHPRD
S209ASNFKsPVKTIRegPhos; SysPTM
S2MSSSEeVP67870(Casein kinase II )RegPhos
S8SSEEVsWISWFHPRD
S3MSSSEeVSCK2_groupRegPhos
S2MSSSEeVCK2 betaRegPhos
S4EVSWHPRD; phosphoELM
S209ASNFKsPVKTphosphoELM; SysPTM
S3EEVSCK2_groupphosphoELM
S3EEVSCSNK2BHPRD
S209ASNFKsPVKTICDC2RegPhos; SysPTM
S3MSSSEeVSP67870(Casein kinase II )RegPhos
S2MSSSEeVCK2_groupRegPhos
S3EEVSphosphoELM
S209ASNFKsPVKTCDK1HPRD; phosphoELM; SysPTM
S209ASNFKsPVKTCDK_groupphosphoELM; SysPTM
S2SEEVCSNK2BHPRD
S209ASNFKsPVKTICDC2(CDK1RegPhos; SysPTM
S209ASNFKsPVKTICDK_groupRegPhos; SysPTM
Y197IHPMAyQLQLQHPRD
T213KSPVKtHPRD; SysPTM
S3EEVSCK2_betaphosphoELM
S2SEEVCK2_betaphosphoELM

Dephosphorylation site
CSK2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000365026S209CCOSMICHepatocellular Carcinoma
ENSP00000365025S209CBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
CSK2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CSK2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK2B_HUMANUB2R1_HUMANkinase -> substrateHPRD
CDK1_HUMANCSK2B_HUMANkinase -> substrateHPRD; RegPhos
CSK2B_HUMANBRCA1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANCSK2B_HUMANkinase -> substrateRegPhos
CSK2B_HUMANC163A_HUMANkinase -> substrateHPRD
CSK2B_HUMANRBX2_HUMANkinase -> substrateHPRD
CSK2B_HUMANBID_HUMANkinase -> substrateHPRD
CSK2B_HUMANCSK2B_HUMANkinase -> substrateHPRD
CSK2B_HUMANNEP_HUMANkinase -> substrateHPRD
CSK2B_HUMANCTDP1_HUMANkinase -> substrateHPRD
CSK2B_HUMANIF5_HUMANkinase -> substrateHPRD
CSK2B_HUMANOCLN_HUMANkinase -> substrateHPRD
CSK2B_HUMANIRS1_HUMANkinase -> substrateHPRD
CSK2B_HUMANHXB6_HUMANkinase -> substrateHPRD
CSK2B_HUMANCTNB1_HUMANkinase -> substrateHPRD
CSK2B_HUMANUSO1_HUMANkinase -> substrateHPRD
CSK2B_HUMANP53_HUMANkinase -> substrateHPRD
ETS1_HUMANCSK2B_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03008Ribosome biogenesis in eukaryotes
hsa05162Measles
hsa04064NF-kappa B signaling pathway
hsa04530Tight junction
hsa05169Epstein-Barr virus infection
hsa05168Herpes simplex infection
hsa04310Wnt signaling pathway
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043623cellular protein complex assemblyNASbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0051101regulation of DNA bindingNASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0033211adiponectin-mediated signaling pathwayIDAbiological_process
GO:0005956protein kinase CK2 complexNAScellular_component
GO:0007165signal transductionTASbiological_process
GO:0032927positive regulation of activin receptor signaling IMPbiological_process
GO:0045859regulation of protein kinase activityNASbiological_process
GO:0061154endothelial tube morphogenesisIMPbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function
GO:0043537negative regulation of blood vessel endothelial ceIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0019887protein kinase regulator activityNASmolecular_function
GO:0019904protein domain specific bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0031519PcG protein complexIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005102receptor bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0008285negative regulation of cell proliferationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007411axon guidanceTASbiological_process


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