Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GNAO_HUMAN
Description:guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O [Source:HGNC Symbol;Acc:4389]
Location:chr16 q12.2
Node attribute:Gprotein

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T285KKSPLtICFPEG-alphaPhosphoSitePlus
Y291ICFPEyTGPNTG-alphaPhosphoSitePlus
T4__MGCtLSAEEPhosphoSitePlus
S112VCDVVsRMEDTG-alphaPhosphoSitePlus
S6MGCTLsAEERAPhosphoSitePlus
Y147NRSREyQLNDSG-alphaPhosphoSitePlus

Dephosphorylation site
GNAO_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262494P283SCOSMICSkin Cancer21984974
ENSP00000262493R243HCOSMICBreast Cancer20668451
ENSP00000262494M244VCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000262493Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.415169874
ENSP00000262493Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
GNAO_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SSR4_HUMANGNAO_HUMANGPCR -> GproteingpDB
PE2R3_HUMANGNAO_HUMANGPCR -> GproteingpDB
CXCR6_HUMANGNAO_HUMANGPCR -> GproteingpDB
5HT1A_HUMANGNAO_HUMANGPCR -> GproteingpDB
ADRB3_HUMANGNAO_HUMANGPCR -> GproteingpDB
ADA2C_HUMANGNAO_HUMANGPCR -> GproteingpDB
OPRK_HUMANGNAO_HUMANGPCR -> GproteingpDB
CXCR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
PAR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
PAR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
S1PR5_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR9_HUMANGNAO_HUMANGPCR -> GproteingpDB
S1PR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
AGTR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
LT4R1_HUMANGNAO_HUMANGPCR -> GproteingpDB
CNR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
CXCR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
RL3R2_HUMANGNAO_HUMANGPCR -> GproteingpDB
SSR5_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCBP2_HUMANGNAO_HUMANGPCR -> GproteingpDB
OPRM_HUMANGNAO_HUMANGPCR -> GproteingpDB
GPR63_HUMANGNAO_HUMANGPCR -> GproteingpDB
CASR_HUMANGNAO_HUMANGPCR -> GproteingpDB
C3AR_HUMANGNAO_HUMANGPCR -> GproteingpDB
ACM4_HUMANGNAO_HUMANGPCR -> GproteingpDB
RL3R1_HUMANGNAO_HUMANGPCR -> GproteingpDB
HRH4_HUMANGNAO_HUMANGPCR -> GproteingpDB
LPAR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
GRM4_HUMANGNAO_HUMANGPCR -> GproteingpDB
HCAR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
FZD1_HUMANGNAO_HUMANGPCR -> GproteingpDB
OXER1_HUMANGNAO_HUMANGPCR -> GproteingpDB
DRD2_HUMANGNAO_HUMANGPCR -> GproteingpDB
5HT1B_HUMANGNAO_HUMANGPCR -> GproteingpDB
GRM3_HUMANGNAO_HUMANGPCR -> GproteingpDB
PAR4_HUMANGNAO_HUMANGPCR -> GproteingpDB
GP132_HUMANGNAO_HUMANGPCR -> GproteingpDB
AGTR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
CXCR5_HUMANGNAO_HUMANGPCR -> GproteingpDB
OGR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
GPR17_HUMANGNAO_HUMANGPCR -> GproteingpDB
SSR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
GABR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
HCAR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
SSR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
LSHR_HUMANGNAO_HUMANGPCR -> GproteingpDB
PSYR_HUMANGNAO_HUMANGPCR -> GproteingpDB
PD2R2_HUMANGNAO_HUMANGPCR -> GproteingpDB
AA3R_HUMANGNAO_HUMANGPCR -> GproteingpDB
LPAR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
P2Y12_HUMANGNAO_HUMANGPCR -> GproteingpDB
MCHR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
MTR1A_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR8_HUMANGNAO_HUMANGPCR -> GproteingpDB
GABR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR4_HUMANGNAO_HUMANGPCR -> GproteingpDB
ACM2_HUMANGNAO_HUMANGPCR -> GproteingpDB
FSHR_HUMANGNAO_HUMANGPCR -> GproteingpDB
GALR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
GRM8_HUMANGNAO_HUMANGPCR -> GproteingpDB
EDNRB_HUMANGNAO_HUMANGPCR -> GproteingpDB
OXYR_HUMANGNAO_HUMANGPCR -> GproteingpDB
5HT5A_HUMANGNAO_HUMANGPCR -> GproteingpDB
LPAR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR5_HUMANGNAO_HUMANGPCR -> GproteingpDB
PTAFR_HUMANGNAO_HUMANGPCR -> GproteingpDB
PAR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
LT4R2_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
5HT1E_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
GPR6_HUMANGNAO_HUMANGPCR -> GproteingpDB
GPR12_HUMANGNAO_HUMANGPCR -> GproteingpDB
ADA2A_HUMANGNAO_HUMANGPCR -> GproteingpDB
S1PR3_HUMANGNAO_HUMANGPCR -> GproteingpDB
NPY4R_HUMANGNAO_HUMANGPCR -> GproteingpDB
CXCR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
HRH3_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR6_HUMANGNAO_HUMANGPCR -> GproteingpDB
ADA2B_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR2_HUMANGNAO_HUMANGPCR -> GproteingpDB
NPY2R_HUMANGNAO_HUMANGPCR -> GproteingpDB
GRM7_HUMANGNAO_HUMANGPCR -> GproteingpDB
AA1R_HUMANGNAO_HUMANGPCR -> GproteingpDB
FPR1_HUMANGNAO_HUMANGPCR -> GproteingpDB
DRD3_HUMANGNAO_HUMANGPCR -> GproteingpDB
CCR10_HUMANGNAO_HUMANGPCR -> GproteingpDB
OPRX_HUMANGNAO_HUMANGPCR -> GproteingpDB
NPY5R_HUMANGNAO_HUMANGPCR -> GproteingpDB
CXCR4_HUMANGNAO_HUMANGPCR -> GproteingpDB
GRM2_HUMANGNAO_HUMANGPCR -> GproteingpDB
GNAO_HUMANTBA1B_HUMANGprotein -> effectorgpDB
GNAO_HUMANCAC1E_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBG1_HUMANGprotein -> effectorgpDB
GNAO_HUMANADCY5_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB6_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB4A_HUMANGprotein -> effectorgpDB
GNAO_HUMANADCY1_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA4A_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB2A_HUMANGprotein -> effectorgpDB
GNAO_HUMANGRIN2_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBD_HUMANGprotein -> effectorgpDB
GNAO_HUMANCSK_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB4B_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA3C_HUMANGprotein -> effectorgpDB
GNAO_HUMANCAC1B_HUMANGprotein -> effectorgpDB
GNAO_HUMANGRIN1_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBAL3_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA8_HUMANGprotein -> effectorgpDB
GNAO_HUMANADCY6_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA4B_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB3_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB2B_HUMANGprotein -> effectorgpDB
GNAO_HUMANCAC1A_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB5_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB1_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBG2_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA1A_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA3E_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBE_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBB8_HUMANGprotein -> effectorgpDB
GNAO_HUMANTBA1C_HUMANGprotein -> effectorgpDB
GNAO_HUMANSRC_HUMANGprotein -> effectorgpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04916Melanogenesis
hsa04727GABAergic synapse
hsa05032Morphine addiction
hsa05142Chagas disease (American trypanosomiasis)
hsa05034Alcoholism
hsa04726Serotonergic synapse
hsa04725Cholinergic synapse
hsa04730Long-term depression
hsa04728Dopaminergic synapse
hsa04724Glutamatergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05145Toxoplasmosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051430corticotropin-releasing hormone receptor 1 bindingIEAmolecular_function
GO:0031683G-protein beta/gamma-subunit complex bindingIBAmolecular_function
GO:0008016regulation of heart contractionIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0007626locomotory behaviorIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0043005neuron projectionIEAcellular_component
GO:0006936muscle contractionTASbiological_process
GO:0051926negative regulation of calcium ion transportIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0034097response to cytokine stimulusIEAbiological_process
GO:0031821G-protein coupled serotonin receptor bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0003924GTPase activityIBAmolecular_function
GO:0010243response to organic nitrogenIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0031175neuron projection developmentIEAbiological_process
GO:0043547positive regulation of GTPase activityIEAbiological_process
GO:0019001guanyl nucleotide bindingIEAmolecular_function
GO:0007212dopamine receptor signaling pathwayIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0006184GTP catabolic processIBAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIBAbiological_process
GO:0016020membraneIEAcellular_component
GO:0043278response to morphineIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0009987cellular processIEAbiological_process
GO:0031234extrinsic to internal side of plasma membraneIBAcellular_component
GO:0005834heterotrimeric G-protein complexIBAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0031852mu-type opioid receptor bindingIEAmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process