| UniProt/SwissProt ID: | CAC1E_HUMAN |
| Description: | calcium channel, voltage-dependent, R type, alpha 1E subunit [Source:HGNC Symbol;Acc:1392] |
| Location: | chr1 q25.3 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1686 | DTTAPsGQNEN | Ion_trans | PhosphoSitePlus |
| T1683 | CEPDTtAPSGQ | Ion_trans | PhosphoSitePlus |
| S2263 | TSLGRsNTIGS | PhosphoSitePlus | |
| S1975 | VSELKsVQPSN | PhosphoSitePlus | |
| S1861 | PMPKAsDLTVG | Ca_chan_IQ | PhosphoSitePlus |
| T1567 | SKLVNtSGFNM | Ion_trans | PhosphoSitePlus |
| Y1877 | MMIMDyYKQSK | Ca_chan_IQ | PhosphoSitePlus |
| S815 | PLNPLsSLNPL | PhosphoSitePlus | |
| T635 | NFNDGtPSANF | Ion_trans | PhosphoSitePlus |
| T1864 | KASDLtVGKIY | Ca_chan_IQ | PhosphoSitePlus |
| S637 | NDGTPsANFDT | Ion_trans | PhosphoSitePlus |
| Y1217 | LQDGSyFRDLW | Ion_trans | PhosphoSitePlus |
| S1568 | KLVNTsGFNMS | Ion_trans | PhosphoSitePlus |
| S816 | LNPLSsLNPLN | PhosphoSitePlus | |
| Dephosphorylation site |
| CAC1E_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000356542 | L609V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356542 | R2243W | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000434814 | R2224W | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356545 | L609V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356542 | A250S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356545 | R2286W | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356545 | V615I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000434814 | V615I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000434814 | A250S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356542 | V615I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000434814 | L609V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000356545 | A250S | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| CAC1E_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CAC1E_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GBG10_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GNAO_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG12_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG3_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBB5_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBB2_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG2_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBB1_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG13_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBB3_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG5_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG11_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG8_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| GBG1_HUMAN | CAC1E_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04930 | Type II diabetes mellitus |
| hsa04020 | Calcium signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005891 | voltage-gated calcium channel complex | IEA | cellular_component |
| GO:0001662 | behavioral fear response | IEA | biological_process |
| GO:0019226 | transmission of nerve impulse | IEA | biological_process |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0048265 | response to pain | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0008542 | visual learning | IEA | biological_process |
| GO:0030317 | sperm motility | IEA | biological_process |
| GO:0042596 | fear response | IEA | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0007626 | locomotory behavior | IEA | biological_process |
| GO:0042593 | glucose homeostasis | IEA | biological_process |
| GO:0005216 | ion channel activity | IEA | molecular_function |
| GO:0005245 | voltage-gated calcium channel activity | IEA | molecular_function |
| GO:0051899 | membrane depolarization | TAS | biological_process |
| GO:0006816 | calcium ion transport | IEA | biological_process |
| GO:0050796 | regulation of insulin secretion | TAS | biological_process |
| GO:0048266 | behavioral response to pain | IEA | biological_process |
| GO:0006112 | energy reserve metabolic process | TAS | biological_process |
| GO:0006811 | ion transport | IEA | biological_process |
| GO:0061178 | regulation of insulin secretion involved in cellul | IEA | biological_process |
| GO:0002027 | regulation of heart rate | IEA | biological_process |
| GO:0019233 | sensory perception of pain | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006810 | transport | TAS | biological_process |
| GO:0090273 | regulation of somatostatin secretion | IEA | biological_process |
| GO:0050877 | neurological system process | IEA | biological_process |
| GO:0055085 | transmembrane transport | IEA | biological_process |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0070588 | calcium ion transmembrane transport | IEA | biological_process |