Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RRN3_HUMAN
Description:RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:30346]
Location:chr16 p13.11
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S633DTHFRsPSSSVPhosphoSitePlus
S199ARYVPsTPWFLHPRD
S44NDFFNsPPRKTHPRD; phosphoELM; SysPTM
S649LYMQPsPLRSK2RegPhos
T623TVIGItPSSFDPhosphoSitePlus
S199ARYVPsTPWFLRRN3PhosphoSitePlus
T200RYVPStPWFLMMAPK9phosphoELM
S640SSSVGsPPVLYPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S170GDVDVsDSDDERRN3PhosphoSitePlus
S635HFRSPsSSVGSPhosphoSitePlus
S649LYMQPsPL___PhosphoSitePlus
S319LDILMsLVLSYRRN3PhosphoSitePlus
S172VDVSDsDDEDDHPRD; phosphoELM
T200RYVPStPWFLMRRN3PhosphoSitePlus
T271AEETAtQTCGGRRN3PhosphoSitePlus
S633DTHFRsPSSSVMAPK3phosphoELM
S172VDVSDsDDEDDRRN3PhosphoSitePlus
S633DTHFRsPSSSVErk1(MAPK3RegPhos
S233NLLRIsVYFPTRRN3PhosphoSitePlus
S170GDVDVsDSDDEHPRD; phosphoELM
S44NDFFNsPPRKTRRN3PhosphoSitePlus; SysPTM
T200RYVPStPWFLMJNK2(MAPK9RegPhos
S649LYMQPsRSK-2phosphoELM

Dephosphorylation site
RRN3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000198767Q550fs*18COSMICOvarian Cancer21720365
ENSP00000198767E288KCOSMICOvarian Cancer21720365

Differential expressed protein
RRN3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RRN3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A3_HUMANRRN3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK09_HUMANRRN3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK03_HUMANRRN3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RRN3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042254ribosome biogenesisIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:2000142regulation of DNA-dependent transcription, initiatIEAbiological_process
GO:0005730nucleolusIDAcellular_component
GO:0006361transcription initiation from RNA polymerase I proIEAbiological_process
GO:0007000nucleolus organizationIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0070063RNA polymerase bindingIEAmolecular_function
GO:0003743translation initiation factor activityIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:0048872homeostasis of number of cellsIEAbiological_process
GO:0006352DNA-dependent transcription, initiationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0007028cytoplasm organizationIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component


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