| UniProt/SwissProt ID: | RRN3_HUMAN |
| Description: | RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:30346] |
| Location: | chr16 p13.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S633 | DTHFRsPSSSV | PhosphoSitePlus | |
| S199 | ARYVPsTPWFL | HPRD | |
| S44 | NDFFNsPPRKT | HPRD; phosphoELM; SysPTM | |
| S649 | LYMQPsPL | RSK2 | RegPhos |
| T623 | TVIGItPSSFD | PhosphoSitePlus | |
| S199 | ARYVPsTPWFL | RRN3 | PhosphoSitePlus |
| T200 | RYVPStPWFLM | MAPK9 | phosphoELM |
| S640 | SSSVGsPPVLY | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S170 | GDVDVsDSDDE | RRN3 | PhosphoSitePlus |
| S635 | HFRSPsSSVGS | PhosphoSitePlus | |
| S649 | LYMQPsPL___ | PhosphoSitePlus | |
| S319 | LDILMsLVLSY | RRN3 | PhosphoSitePlus |
| S172 | VDVSDsDDEDD | HPRD; phosphoELM | |
| T200 | RYVPStPWFLM | RRN3 | PhosphoSitePlus |
| T271 | AEETAtQTCGG | RRN3 | PhosphoSitePlus |
| S633 | DTHFRsPSSSV | MAPK3 | phosphoELM |
| S172 | VDVSDsDDEDD | RRN3 | PhosphoSitePlus |
| S633 | DTHFRsPSSSV | Erk1(MAPK3 | RegPhos |
| S233 | NLLRIsVYFPT | RRN3 | PhosphoSitePlus |
| S170 | GDVDVsDSDDE | HPRD; phosphoELM | |
| S44 | NDFFNsPPRKT | RRN3 | PhosphoSitePlus; SysPTM |
| T200 | RYVPStPWFLM | JNK2(MAPK9 | RegPhos |
| S649 | LYMQPs | RSK-2 | phosphoELM |
| Dephosphorylation site |
| RRN3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000198767 | Q550fs*18 | COSMIC | Ovarian Cancer | 21720365 | ENSP00000198767 | E288K | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RRN3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RRN3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6A3_HUMAN | RRN3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MK09_HUMAN | RRN3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MK03_HUMAN | RRN3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RRN3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0042254 | ribosome biogenesis | IEA | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:2000142 | regulation of DNA-dependent transcription, initiat | IEA | biological_process |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0006361 | transcription initiation from RNA polymerase I pro | IEA | biological_process |
| GO:0007000 | nucleolus organization | IEA | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0070063 | RNA polymerase binding | IEA | molecular_function |
| GO:0003743 | translation initiation factor activity | IEA | molecular_function |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0006360 | transcription from RNA polymerase I promoter | TAS | biological_process |
| GO:0048872 | homeostasis of number of cells | IEA | biological_process |
| GO:0006352 | DNA-dependent transcription, initiation | IEA | biological_process |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0007028 | cytoplasm organization | IEA | biological_process |
| GO:0008283 | cell proliferation | IEA | biological_process |
| GO:0005488 | binding | IEA | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |