Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMAD2_HUMAN
Description:SMAD family member 2 [Source:HGNC Symbol;Acc:6768]
Location:chr18 q21.1
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S467RCSSMs_____PhosphoSitePlus
S465SVRCSsTGFbR1phosphoELM
T8SILPFtPPVVKMAPK3HPRD; phosphoELM; SysPTM
S464PSVRCsSACVR1BHPRD
S464PSVRCsSphosphoELM
S255SPTTLsPVNHSMAPK3phosphoELM
S240QQLNQsMDTGSCAMK2_groupRegPhos
S240QQLNQsMDTGSPhosphoSitePlus
S110SEQTRsLDGRLMH1PhosphoSitePlus
S467RCSSMsTGFbR1RegPhos
S417CTIRMsFVKGWMH2PhosphoSitePlus
S467RCSSTGFBR1HPRD
S250SPAELsPTTLSErk1(MAPK3RegPhos
S460QMGSPsVRCSSPhosphoSitePlus; HPRD
S465SVRCSsMSRegPhos
S458LTQMGsPSVRCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S464PSVRCsSBMPR1BphosphoELM
T220NYIPEtPPPGYPhosphoSitePlus; phosphoELM; RegPhos
Y165VCVNPyHYQRVMH1PhosphoSitePlus
T220NYIPEtPPPGYMAPK1HPRD
T220NYIPEtPPPGYMAPK3phosphoELM
S464PSVRCsSMSTGFbR1RegPhos
S240QQLNQsMDTGSCaMK2aRegPhos
S465SVRCSsBMPR1BphosphoELM
S245SMDTGsPAELSErk1(MAPK3RegPhos
S245SMDTGsPAELSErk2RegPhos
S467RCSSMsRegPhos
S465SVRCSsphosphoELM
S464PSVRCsSTGFBR1HPRD
S2ILPFHPRD
Y102DTTGLySFSEQMH1PhosphoSitePlus
S465SVRCSsACVR1BHPRD
S464PSVRCsSMSALK4RegPhos
S250SPAELsPTTLSErk2RegPhos
T8SILPFtPPVVKPhosphoSitePlus; phosphoELM; SysPTM
S467RCSSMsALK4RegPhos
T220NYIPEtPPPGYErk1(MAPK3RegPhos
T324VNRNAtVEMTRMH2PhosphoSitePlus
T172YQRVEtPVLPPPhosphoSitePlus
S245SMDTGsPAELSPhosphoSitePlus; phosphoELM; RegPhos
T197PLDDYtHSIPEPhosphoSitePlus
S467RCSSACVR1BHPRD
S465SVRCSsTGFBR1HPRD
S467RCSSBMPR1BphosphoELM
S255SPTTLsPVNHSErk1(MAPK3RegPhos
T8SILPFtPPVVKErk1RegPhos; SysPTM
S245SMDTGsPAELSMAPK1HPRD
S245SMDTGsPAELSMAPK3phosphoELM
T220NYIPEtPPPGYErk2RegPhos
S260SPVNHsLDLQPPhosphoSitePlus
S260SPVNHsLDLQPCAMK2AHPRD
S467RCSSTGFbR1phosphoELM
S467RCSSphosphoELM
S2____MsSILPFPhosphoSitePlus
S465SVRCSsMSALK4RegPhos
S118GRLQVsHRKGLMH1PhosphoSitePlus
S250SPAELsPTTLSMAPK3phosphoELM
S250SPAELsPTTLSMAPK1HPRD
S465SVRCSsMS___PhosphoSitePlus
S260SPVNHsLDLQPCaMK2aRegPhos
S250SPAELsPTTLSPhosphoSitePlus; phosphoELM; RegPhos
S255SPTTLsPVNHSPhosphoSitePlus; phosphoELM; RegPhos
S110SEQTRsLDGRLCaMK2aRegPhos
S464PSVRCsSTGFbR1phosphoELM
S110SEQTRsLDGRLCAMK2AHPRD
Y128LPHVIyCRLWRMH1PhosphoSitePlus
S240QQLNQsMDTGSCAMK2AHPRD
S465SVRCSsMSTGFbR1RegPhos
T8SILPFtPPVVKErk1(MAPK3RegPhos; SysPTM
S464PSVRCsSMS__PhosphoSitePlus

Dephosphorylation site
SMAD2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000384449D450EHPIColorectal Cancer8752209 10438456
ENSP00000384449D300VHPIColorectal Cancer16959974
ENSP00000262160W422*COSMICHepatocellular Carcinoma21822264
ENSP00000384449L440RHPIColorectal Cancer8752209
ENSP00000262160D450EHPIColorectal Cancer8752209 10438456
ENSP00000384449R133CHPIColorectal Cancer8752209
ENSP00000262160L440RHPIColorectal Cancer8752209
ENSP00000384449S245CDing2008, COSMICLung Cancer18948947
ENSP00000262160R133CHPIColorectal Cancer8752209
ENSP00000384449R334KBIOMARTBreast Cancer21930507, 21930502
ENSP00000262160S245CDing2008, COSMICLung Cancer18948947
ENSP00000384449P445HHPIColorectal Cancer8752209 11313456 10438456
ENSP00000384449D300VSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000262160D300VHPIColorectal Cancer16959974
ENSP00000262160R334KBIOMARTBreast Cancer21930507, 21930502
ENSP00000262160D300VSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000349282R304KBIOMARTBreast Cancer21930507, 21930502
ENSP00000262160P445HHPIColorectal Cancer8752209 11313456 10438456
ENSP00000384449W422*COSMICHepatocellular Carcinoma21822264

Differential expressed protein
SMAD2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S467SVRCSSMs_______Marfan syndrome15731757PhosphoSitePlus
S465SPSVRCSsMS_____Marfan syndrome15731757PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ACV1C_HUMANSMAD2_HUMANkinase -> substrateKEGG
KCC2A_HUMANSMAD2_HUMANkinase -> substrateHPRD
ZAGL2_HUMANSMAD2_HUMANkinase -> substrateRegPhos
PTK6_HUMANSMAD2_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANSMAD2_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KCC2B_HUMANSMAD2_HUMANkinase -> substrateRegPhos
TGFR1_HUMANSMAD2_HUMANkinase -> substrateKEGG; HPRD
ACV1B_HUMANSMAD2_HUMANkinase -> substrateRegPhos
STK11_HUMANSMAD2_HUMANkinase -> substrateRobert H Newman (2013)
ACVR1_HUMANSMAD2_HUMANkinase -> substrateKEGG
MK01_HUMANSMAD2_HUMANkinase -> substrateHPRD
TGFB1_HUMANSMAD2_HUMANotherKEGG
SMAD2_HUMANSMAD4_HUMANotherKEGG
ZFYV9_HUMANSMAD2_HUMANotherKEGG
SMAD6_HUMANSMAD2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway
hsa05210Colorectal cancer
hsa04520Adherens junction
hsa04110Cell cycle
hsa04350TGF-beta signaling pathway
hsa04144Endocytosis
hsa05200Pathways in cancer
hsa05212Pancreatic cancer
hsa05166HTLV-I infection
hsa05142Chagas disease (American trypanosomiasis)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009952anterior/posterior pattern specificationISSbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0031053primary miRNA processingTASbiological_process
GO:0051098regulation of bindingIEAbiological_process
GO:0045165cell fate commitmentIEAbiological_process
GO:0007492endoderm developmentIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0030618transforming growth factor beta receptor, pathway-IDAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0048617embryonic foregut morphogenesisIEAbiological_process
GO:0035556intracellular signal transductionISSbiological_process
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0032924activin receptor signaling pathwayIMPbiological_process
GO:0005634nucleusIDAcellular_component
GO:0030324lung developmentIEAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0046332SMAD bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0007369gastrulationIEAbiological_process
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0003690double-stranded DNA bindingISSmolecular_function
GO:0007182common-partner SMAD protein phosphorylationIDAbiological_process
GO:0033613activating transcription factor bindingIPImolecular_function
GO:0005622intracellularIEAcellular_component
GO:0030513positive regulation of BMP signaling pathwayIMPbiological_process
GO:0048340paraxial mesoderm morphogenesisIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:0031016pancreas developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007179transforming growth factor beta receptor signalingIDAbiological_process
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0007389pattern specification processIEAbiological_process
GO:0048589developmental growthIEAbiological_process
GO:0001707mesoderm formationISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0034713type I transforming growth factor beta receptor biIPImolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0043234protein complexIEAcellular_component
GO:0060021palate developmentISSbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0030073insulin secretionIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIMPbiological_process
GO:0005160transforming growth factor beta receptor bindingIPImolecular_function
GO:0051098regulation of bindingISSbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0005829cytosolTAScellular_component
GO:0071141SMAD protein complexIDAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0048340paraxial mesoderm morphogenesisISSbiological_process
GO:0060021palate developmentIEAbiological_process
GO:1900224positive regulation of nodal signaling pathway invIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyTASbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0038092nodal signaling pathwayIMPbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0017015regulation of transforming growth factor beta receIMPbiological_process
GO:0019902phosphatase bindingIPImolecular_function
GO:0010718positive regulation of epithelial to mesenchymal tISSbiological_process
GO:0009880embryonic pattern specificationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0070723response to cholesterolIDAbiological_process
GO:0007369gastrulationTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0060039pericardium developmentIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0035265organ growthIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0070411I-SMAD bindingIPImolecular_function
GO:0046332SMAD bindingIEAmolecular_function
GO:0008134transcription factor bindingIEAmolecular_function
GO:0032444activin responsive factor complexIDAcellular_component
GO:0007352zygotic specification of dorsal/ventral axisIMPbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
GO:0001707mesoderm formationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045165cell fate commitmentISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0070410co-SMAD bindingIPImolecular_function