| UniProt/SwissProt ID: | SRBP2_HUMAN |
| Description: | sterol regulatory element binding transcription factor 2 [Source:HGNC Symbol;Acc:11290] |
| Location: | chr22 q13.2 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y840 | SSALEyLKLLH | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S432 | NVLLMsPPASD | PhosphoSitePlus | |
| T124 | TSVPTtPRATP | PhosphoSitePlus | |
| S1121 | VGDRRsCNDCQ | RegPhos | |
| S80 | NGRGSsSGAVD | PhosphoSitePlus | |
| S455 | DSEPGsPLLDD | MAPK3 | phosphoELM |
| S455 | DSEPGsPLLDD | MAPK1 | phosphoELM |
| S455 | DSEPGsPLLDD | PhosphoSitePlus | |
| T153 | QTVMItPTFST | PhosphoSitePlus | |
| S79 | SNGRGsSSGAV | PhosphoSitePlus | |
| T155 | VMITPtFSTTP | PhosphoSitePlus | |
| Y171 | QQPLIyQNAAT | PhosphoSitePlus | |
| S432 | NVLLMsPPASD | MAPK3 | phosphoELM |
| S432 | NVLLMsPPASD | Erk2(MAPK1 | RegPhos |
| S432 | NVLLMsPPASD | MAPK1 | phosphoELM |
| S1046 | LMAGAsPTRTH | PhosphoSitePlus | |
| S120 | KVSPTsVPTTP | PhosphoSitePlus | |
| S455 | DSEPGsPLLDD | Erk1(MAPK3 | RegPhos |
| S455 | DSEPGsPLLDD | Erk2(MAPK1 | RegPhos |
| S81 | GRGSSsGAVDP | PhosphoSitePlus | |
| S432 | NVLLMsPPASD | Erk1(MAPK3 | RegPhos |
| Dephosphorylation site |
| SRBP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000354476 | N347K | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000354476 | G82R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000354476 | T360I | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000354476 | A273S | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000354476 | A442T | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000354476 | Testicular Cancer | Normal vs. Cancer | cell line | Down | 18489135 | |
| Hyperphosphorylation site |
| SRBP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK03_HUMAN | SRBP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | SRBP2_HUMAN | kinase -> substrate | RegPhos |
| MK01_HUMAN | SRBP2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRBP2_HUMAN | PPARG_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| SRBP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0072368 | regulation of lipid transport by negative regulati | IDA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IDA | biological_process |
| GO:0071499 | cellular response to laminar fluid shear stress | NAS | biological_process |
| GO:0008203 | cholesterol metabolic process | IEA | biological_process |
| GO:0045944 | positive regulation of transcription from RNA poly | IEA | biological_process |
| GO:0000978 | RNA polymerase II core promoter proximal region se | IDA | molecular_function |
| GO:0055098 | response to low-density lipoprotein particle stimu | IEP | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0012507 | ER to Golgi transport vesicle membrane | IEA | cellular_component |
| GO:0000122 | negative regulation of transcription from RNA poly | IDA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0046983 | protein dimerization activity | IEA | molecular_function |
| GO:0070888 | E-box binding | IDA | molecular_function |
| GO:2000188 | regulation of cholesterol homeostasis | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0006629 | lipid metabolic process | TAS | biological_process |
| GO:0032933 | SREBP signaling pathway | IEA | biological_process |
| GO:0010886 | positive regulation of cholesterol storage | IDA | biological_process |
| GO:0000139 | Golgi membrane | IEA | cellular_component |
| GO:0090370 | negative regulation of cholesterol efflux | IDA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0032937 | SREBP-SCAP-Insig complex | IDA | cellular_component |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |