Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TAL1_HUMAN
Description:T-cell acute lymphocytic leukemia 1 [Source:HGNC Symbol;Acc:11556]
Location:chr1 p33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S316KHTARsLHPAMPhosphoSitePlus
S122RMVQLsPPALAErk1(MAPK3RegPhos
S141LLYSLsQPLASPhosphoSitePlus
S139RALLYsLSQPLPhosphoSitePlus
T216RKLIPtHPPDKHLHPhosphoSitePlus
S172VKRRPsPYEMEPhosphoSitePlus; HPRD; RegPhos
Y138GRALLySLSQPPhosphoSitePlus
S122RMVQLsPPALAPhosphoSitePlus; RegPhos
S172VKRRPsPYEMEPKA_groupphosphoELM; RegPhos
T90RHRVPtTELCRPhosphoSitePlus; phosphoELM; RegPhos
T91HRVPTtELCRPPhosphoSitePlus
S107APAPAsVTAELPhosphoSitePlus
S122RMVQLsPPALAErk1RegPhos
S146SQPLAsLGSGFPhosphoSitePlus
S149LASLGsGFFGEPhosphoSitePlus
S122RMVQLsPPALAMAPK3HPRD; phosphoELM

Dephosphorylation site
TAL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000360951R315LCOSMICLung Cancer20668451
ENSP00000294339R315LCOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000294339Pancreatic CancerNormal vs. CancertissueUp619199705

Hyperphosphorylation site
TAL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANTAL1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANTAL1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
TAL1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070888E-box bindingIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0030219megakaryocyte differentiationIEPbiological_process
GO:0060375regulation of mast cell differentiationIEAbiological_process
GO:0035855megakaryocyte developmentIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0045637regulation of myeloid cell differentiationIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0051781positive regulation of cell divisionIMPbiological_process
GO:0045165cell fate commitmentISSbiological_process
GO:0030097hemopoiesisIEAbiological_process
GO:0060018astrocyte fate commitmentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0045648positive regulation of erythrocyte differentiationISSbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0045165cell fate commitmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0033193Lsd1/2 complexIDAcellular_component
GO:0044212transcription regulatory region DNA bindingISSmolecular_function
GO:0070888E-box bindingIDAmolecular_function
GO:0045648positive regulation of erythrocyte differentiationIEAbiological_process
GO:0060217hemangioblast cell differentiationIEAbiological_process
GO:0030219megakaryocyte differentiationIEAbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0048699generation of neuronsIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0060218hematopoietic stem cell differentiationIEAbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0035162embryonic hemopoiesisISSbiological_process
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0030218erythrocyte differentiationIMPbiological_process
GO:0021527spinal cord association neuron differentiationIEAbiological_process
GO:0042826histone deacetylase bindingIPImolecular_function
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0000118histone deacetylase complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0031334positive regulation of protein complex assemblyIDAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0030220platelet formationIEAbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0000976transcription regulatory region sequence-specific IEAmolecular_function
GO:0045799positive regulation of chromatin assembly or disasIMPbiological_process
GO:0030097hemopoiesisISSbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0030221basophil differentiationIEPbiological_process
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0003682chromatin bindingIDAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0007626locomotory behaviorIEAbiological_process
GO:0060216definitive hemopoiesisIEAbiological_process
GO:0030099myeloid cell differentiationIEAbiological_process
GO:0043249erythrocyte maturationIEAbiological_process
GO:2000036regulation of stem cell maintenanceIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function