Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	MP2K2_HUMAN
Description:	mitogen-activated protein kinase kinase 2 [Source:HGNC Symbol;Acc:6842]
Location:	chr19 p13.3
Node attribute:	kinase; substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S222	GQLIDsMANSF	MAP3K8	phosphoELM; RegPhos
S26	GPSPTsEGASE	MAP2K2	HPRD
T396	QPGTPtRT	MAP2K2	HPRD
S94	VQHRPsGLIMA	Pkinase	PhosphoSitePlus
S222	GQLIDsMANSF		HPRD; phosphoELM
S216	CDFGVsGQLID		phosphoELM; RegPhos
T230	NSFVGtRSYMA		HPRD
S293	EGEPHsISPRP		HPRD
S226	DSMANsFVGTR	MAP2K2	HPRD
S216	CDFGVsGQLID	Pkinase	PhosphoSitePlus
T398	GTPTRtAV___		PhosphoSitePlus
T394	LNQPGtPTRT		HPRD; phosphoELM
S295	EPHSIsPRPRP	Pkinase	PhosphoSitePlus
S293	EGEPHsISPRP	Pkinase	PhosphoSitePlus
T396	QPGTPtRTAV		RegPhos
T25	EGPSPtSEGAS		HPRD
S226	DSMANsFVGTR	Pkinase	PhosphoSitePlus
S222	GQLIDsMANSF	RAF_group	RegPhos
S222	GQLIDsMANSF	Pkinase	PhosphoSitePlus
S306	PGRPVsGHGMD	Pkinase	PhosphoSitePlus
S26	GPSPTsEGASE		PhosphoSitePlus
T230	NSFVGtRSYMA	Pkinase	PhosphoSitePlus
S226	DSMANsFVGTR		phosphoELM; RegPhos
S226	DSMANsFVGTR	PDK-1	phosphoELM
S226	DSMANsFVGTR	MAP3K8	phosphoELM; RegPhos
S198	RDVKPsNILVN	Pkinase	PhosphoSitePlus
S295	EPHSIsPRPRP		HPRD; phosphoELM
T396	QPGTPtRT		HPRD; phosphoELM
S23	IAEGPsPTSEG		PhosphoSitePlus; HPRD; phosphoELM; RegPhos
S372	TFIKRsEVEEV		PhosphoSitePlus; HPRD
T396	QPGTPtRTAV_		PhosphoSitePlus
S226	DSMANsFVGTR	PDK1	RegPhos
T394	LNQPGtPTRTA		PhosphoSitePlus; RegPhos

Dephosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
Y244	ERLQGTHySVQSDIW	DUSP3	HPRD

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000262948	K39M	COSMIC	Ovarian Cancer	21720365

Differential expressed protein

MP2K2_HUMAN is not differential expressed protein.

Hyperphosphorylation site

Site	Motif	Peptide	Cancer name	Pubmed	Source
S226	Pkinase	LIDSMANsFVGTRSY	Alzheimer's disease	17064357	PhosphoSitePlus
S222	Pkinase	VSGQLIDsMANSFVG	Alzheimer's disease	17064357	PhosphoSitePlus

Direct Interaction Pair

Source	Target	Relationship	Resource
MP2K2_HUMAN	MTA1_HUMAN	kinase -> substrate	Robert H Newman (2013)
MP2K2_HUMAN	MP2K2_HUMAN	kinase -> substrate	HPRD
M3K8_HUMAN	MP2K2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
MP2K2_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
MP2K2_HUMAN	MK01_HUMAN	kinase -> substrate	KEGG
MP2K2_HUMAN	MK03_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
ZAGL2_HUMAN	MP2K2_HUMAN	kinase -> substrate	RegPhos
MP2K2_HUMAN	HSF1_HUMAN	kinase -> substrate	Robert H Newman (2013)
BRAF_HUMAN	MP2K2_HUMAN	kinase -> substrate	KEGG
M3K1_HUMAN	MP2K2_HUMAN	kinase -> substrate	KEGG
MOS_HUMAN	MP2K2_HUMAN	kinase -> substrate	KEGG
RAF1_HUMAN	MP2K2_HUMAN	kinase -> substrate	KEGG
PDPK1_HUMAN	MP2K2_HUMAN	kinase -> substrate	RegPhos
MP2K2_HUMAN	CASP9_HUMAN	kinase -> substrate	HPRD; RegPhos
ZHX2_HUMAN	MP2K2_HUMAN	kinase -> substrate	RegPhos
DUS3_HUMAN	MP2K2_HUMAN	phosphatase -> substrate	HPRD

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05214	Glioma
hsa05020	Prion diseases
hsa04810	Regulation of actin cytoskeleton
hsa04664	Fc epsilon RI signaling pathway
hsa04910	Insulin signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04620	Toll-like receptor signaling pathway
hsa04540	Gap junction
hsa05220	Chronic myeloid leukemia
hsa04912	GnRH signaling pathway
hsa05216	Thyroid cancer
hsa04660	T cell receptor signaling pathway
hsa04370	VEGF signaling pathway
hsa05200	Pathways in cancer
hsa04012	ErbB signaling pathway
hsa04916	Melanogenesis
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer
hsa04650	Natural killer cell mediated cytotoxicity
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05164	Influenza A
hsa05215	Prostate cancer
hsa04720	Long-term potentiation
hsa04662	B cell receptor signaling pathway
hsa04730	Long-term depression
hsa05211	Renal cell carcinoma
hsa04722	Neurotrophin signaling pathway
hsa05213	Endometrial cancer
hsa04010	MAPK signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0004708	MAP kinase kinase activity	IEA	molecular_function
GO:0034142	toll-like receptor 4 signaling pathway	TAS	biological_process
GO:0034130	toll-like receptor 1 signaling pathway	TAS	biological_process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0002755	MyD88-dependent toll-like receptor signaling pathw	TAS	biological_process
GO:0007264	small GTPase mediated signal transduction	TAS	biological_process
GO:0090170	regulation of Golgi inheritance	TAS	biological_process
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	biological_process
GO:0005634	nucleus	TAS	cellular_component
GO:0008543	fibroblast growth factor receptor signaling pathwa	TAS	biological_process
GO:0045087	innate immune response	TAS	biological_process
GO:0097110	scaffold protein binding	IPI	molecular_function
GO:0002756	MyD88-independent toll-like receptor signaling pat	TAS	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0000165	MAPK cascade	IEA	biological_process
GO:0002224	toll-like receptor signaling pathway	TAS	biological_process
GO:0043539	protein serine/threonine kinase activator activity	IDA	molecular_function
GO:0030165	PDZ domain binding	IDA	molecular_function
GO:0005739	mitochondrion	TAS	cellular_component
GO:0005938	cell cortex	IEA	cellular_component
GO:0005925	focal adhesion	TAS	cellular_component
GO:0005770	late endosome	TAS	cellular_component
GO:0005778	peroxisomal membrane	IDA	cellular_component
GO:0006468	protein phosphorylation	NAS	biological_process
GO:0008063	Toll signaling pathway	TAS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0032947	protein complex scaffold	IEA	molecular_function
GO:0005911	cell-cell junction	IDA	cellular_component
GO:0000187	activation of MAPK activity	TAS	biological_process
GO:0032872	regulation of stress-activated MAPK cascade	TAS	biological_process
GO:0008286	insulin receptor signaling pathway	TAS	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0007411	axon guidance	TAS	biological_process
GO:0048011	nerve growth factor receptor signaling pathway	TAS	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0005769	early endosome	TAS	cellular_component
GO:0034138	toll-like receptor 3 signaling pathway	TAS	biological_process
GO:2000147	positive regulation of cell motility	IEA	biological_process
GO:0000186	activation of MAPKK activity	TAS	biological_process
GO:0005524	ATP binding	IEA	molecular_function
GO:0035666	TRIF-dependent toll-like receptor signaling pathwa	TAS	biological_process
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0004712	protein serine/threonine/tyrosine kinase activity	TAS	molecular_function
GO:0009898	internal side of plasma membrane	IDA	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:2000641	regulation of early endosome to late endosome tran	TAS	biological_process
GO:0005783	endoplasmic reticulum	IDA	cellular_component
GO:0051403	stress-activated MAPK cascade	TAS	biological_process
GO:0005874	microtubule	IDA	cellular_component
GO:0000165	MAPK cascade	TAS	biological_process
GO:0048471	perinuclear region of cytoplasm	IDA	cellular_component
GO:0005576	extracellular region	NAS	cellular_component
GO:0070371	ERK1 and ERK2 cascade	TAS	biological_process
GO:0036289	peptidyl-serine autophosphorylation	IDA	biological_process
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0007265	Ras protein signal transduction	TAS	biological_process
GO:0034134	toll-like receptor 2 signaling pathway	TAS	biological_process
GO:0071902	positive regulation of protein serine/threonine ki	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network