Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GSK3B_HUMAN
Description:glycogen synthase kinase 3 beta [Source:HGNC Symbol;Acc:4617]
Location:chr3 q13.33
Node attribute:PPI(source); substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S9RPRTTsFAESCRSK_groupphosphoELM; RegPhos
T8GRPRTtSFAESPhosphoSitePlus
S417ASASAsNST__PhosphoSitePlus
T43TTVVAtPGQGPErk2(MAPK1RegPhos
S432ASASNHPRD
T402ASDANtGDRGQPhosphoSitePlus; phosphoELM; RegPhos
S9RPRTTsFAESCAKT1(PKBRegPhos
S9RPRTTsFAESCAKT1HPRD; RegPhos
Y288EMNPNyTEFKFPkinasePhosphoSitePlus
S35RDKDGsKVTTVPhosphoSitePlus
S9RPRTTsFAESCPhosphoSitePlus; phosphoELM
Y114IVRLRyFFYSSPkinasePhosphoSitePlus
Y216EPNVSyICSRYMAP2K1phosphoELM; RegPhos
S219VSYICsRYYRAPkinasePhosphoSitePlus
T390QAAAStPTNATPhosphoSitePlus; phosphoELM; RegPhos
S428NAASAsASNHPRD
T43TTVVAtPGQGPMAPK1phosphoELM
T43TTVVAtPGQGPMAPK3phosphoELM
S21PVQQPsAFGSMPhosphoSitePlus
S9RPRTTsFAESCPKACaRegPhos
S9RPRTTsFAESCPKA_groupphosphoELM; RegPhos
T277VLGTPtREQIRHPRD
S21PVQQPsAFGSMSGK3HPRD; RegPhos
Y222ICSRYyRAPELPkinasePhosphoSitePlus
S13TSFAEsCKPVQPhosphoSitePlus
T275IKVLGtPTREQPkinasePhosphoSitePlus
T277VLGTPtREQIRPkinasePhosphoSitePlus
T392AASTPtNATAAPhosphoSitePlus; phosphoELM
S215GEPNVsYICSRHPRD; RegPhos
T7SGRPRtTSFAEPhosphoSitePlus; RegPhos
S21PVQQPsAFGSMSGK_groupphosphoELM; RegPhos
T7SFAEHPRD; phosphoELM
T415ASDANtGDRGQHPRD
Y117LRYFFySSGEKPkinasePhosphoSitePlus
S402IQAAAsTPTNAHPRD
S389IQAAAsTPTNAPhosphoSitePlus; RegPhos
T395TPTNAtAASDARegPhos
T43TTVVAtPGQGPPhosphoSitePlus
Y216EPNVSyICSRYPkinasePhosphoSitePlus
S25PSAFGsMKVSRPhosphoSitePlus
Y216EPNVSyICSRYHPRD; phosphoELM; RegPhos
T405AASTPtNATAAHPRD
Y71SFGVVyQAKLCPkinasePhosphoSitePlus
S9RPRTTsFAESCSGK3HPRD; RegPhos
S9RPRTTsFAESCPRKACAHPRD
S215GEPNVsYICSRPkinasePhosphoSitePlus
S219VSYICsRYYRAHPRD; RegPhos
Y221YICSRyYRAPEPkinasePhosphoSitePlus
S426TNNAAsASASNHPRD
T403QAAAStPTNATHPRD
T43TTVVAtPGQGPErk1(MAPK3RegPhos
T275IKVLGtPTREQHPRD

Dephosphorylation site
GSK3B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324806*434YCOSMICOvarian Cancer20826764
ENSP00000324806S25CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000324806E121DCOSMICOvarian Cancer21720365
ENSP00000324806Q265*COSMICLung Cancer20668451
ENSP00000324806S313TCOSMICBreast Cancer20668451
ENSP00000324806V361IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
GSK3B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y216PkinaseRGEPNVSyICSRYYRsporadic inclusion-body myositis19878439PhosphoSitePlus
S9SGRPRTTsFAESCKPlymphoma20224723PhosphoSitePlus
S9SGRPRTTsFAESCKPbipolar disprder16806104PhosphoSitePlus
S9SGRPRTTsFAESCKPovarian cancer15208673PhosphoSitePlus
S9SGRPRTTsFAESCKPschizophrenia14745448PhosphoSitePlus
S9SGRPRTTsFAESCKPAlzheimer's disease15033922PhosphoSitePlus
S9SGRPRTTsFAESCKPtype 2 diabetes15033922PhosphoSitePlus
S9SGRPRTTsFAESCKPmelanoma skin cancer19996208PhosphoSitePlus
S9SGRPRTTsFAESCKPAlzheimer's disease22278060PhosphoSitePlus
S9SGRPRTTsFAESCKPpancreatic cancer21474066PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANRPGP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANDPYL2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANANDR_HUMANkinase -> substrateNetPath
GSK3B_HUMANESR1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANASCC1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANHNRPD_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
GSK3B_HUMANBICD1_HUMANkinase -> substrateHPRD
GSK3B_HUMANRCAN1_HUMANkinase -> substrateRegPhos
GSK3B_HUMANCCNE1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MK03_HUMANGSK3B_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANMK67I_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANCABYR_HUMANkinase -> substrateRegPhos
GSK3B_HUMANCDN1A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
SGK1_HUMANGSK3B_HUMANkinase -> substrateRegPhos
GSK3B_HUMANTF65_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANCEBPA_HUMANkinase -> substrateRegPhos
MP2K1_HUMANGSK3B_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANPSPC1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANSMPX_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANFZR_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANMITF_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANGYS1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANCCND1_HUMANkinase -> substrateKEGG; HPRD; RegPhos
GSK3B_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANGSK3B_HUMANkinase -> substrateHPRD; RegPhos; NetPath
GSK3B_HUMANP53_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANAPC_HUMANkinase -> substrateHPRD
GSK3B_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANCSRP3_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANGSK3B_HUMANkinase -> substrateRegPhos
GSK3B_HUMANGLI1_HUMANkinase -> substrateKEGG
GSK3B_HUMANCCND3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GCKR_HUMANGSK3B_HUMANkinase -> substrateNetPath
GSK3B_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANMUC1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
GSK3B_HUMANA4_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
GSK3B_HUMANNFAT5_HUMANkinase -> substrateKEGG
GSK3B_HUMANFOXO1_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANROR2_HUMANkinase -> substrateNetPath
GSK3B_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANMCL1_HUMANkinase -> substrateRegPhos
ILK_HUMANGSK3B_HUMANkinase -> substrateNetPath
GSK3B_HUMANTAU_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANRU17_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANACLY_HUMANkinase -> substrateRegPhos
GSK3B_HUMANCREM_HUMANkinase -> substrateHPRD; RegPhos
GSK3B_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)
AKT3_HUMANGSK3B_HUMANkinase -> substrateKEGG
KPCA_HUMANGSK3B_HUMANkinase -> substrateKEGG; HPRD
GSK3B_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANZHX1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANMYC_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
GSK3B_HUMANPTEN_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANPSN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANIPP2_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
GSK3B_HUMANLRP6_HUMANkinase -> substrateHPRD
GSK3B_HUMANCTNB1_HUMANkinase -> substrateRegPhos; NetPath
GSK3B_HUMANNOTC2_HUMANkinase -> substrateRegPhos; NetPath
GSK3B_HUMANCTND1_HUMANkinase -> substrateRegPhos
GSK3B_HUMANGPBL1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANNACA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANCDX2_HUMANkinase -> substrateRegPhos
GSK3B_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANMYCD_HUMANkinase -> substrateHPRD
GSK3B_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANDPYL3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANCSDC2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANAXIN1_HUMANkinase -> substrateHPRD
GSK3B_HUMANPOP7_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANUBE2A_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANGSK3B_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANEI2BE_HUMANkinase -> substrateRegPhos
GSK3B_HUMANSMRC2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANNFKB1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
GSK3B_HUMANRSBN1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANSNAI1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
SGK3_HUMANGSK3B_HUMANkinase -> substrateRegPhos
GSK3B_HUMANE2AK2_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
GSK3B_HUMANCTNB1_HUMANotherKEGG
DVL1_HUMANGSK3B_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04110Cell cycle
hsa05160Hepatitis C
hsa04662B cell receptor signaling pathway
hsa05162Measles
hsa05010Alzheimer's disease
hsa04510Focal adhesion
hsa04916Melanogenesis
hsa05166HTLV-I infection
hsa04660T cell receptor signaling pathway
hsa04340Hedgehog signaling pathway
hsa04722Neurotrophin signaling pathway
hsa05210Colorectal cancer
hsa04012ErbB signaling pathway
hsa05215Prostate cancer
hsa04360Axon guidance
hsa05169Epstein-Barr virus infection
hsa04728Dopaminergic synapse
hsa04910Insulin signaling pathway
hsa05217Basal cell carcinoma
hsa05164Influenza A
hsa05200Pathways in cancer
hsa04310Wnt signaling pathway
hsa05213Endometrial cancer
hsa04062Chemokine signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005524ATP bindingIEAmolecular_function
GO:0048168regulation of neuronal synaptic plasticityIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0014902myotube differentiationIEAbiological_process
GO:0035556intracellular signal transductionIDAbiological_process
GO:0046827positive regulation of protein export from nucleusIDAbiological_process
GO:0034236protein kinase A catalytic subunit bindingIPImolecular_function
GO:0007163establishment or maintenance of cell polarityIEAbiological_process
GO:0008013beta-catenin bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0030426growth coneIEAcellular_component
GO:0019901protein kinase bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:2000077negative regulation of type B pancreatic cell deveTASbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0005977glycogen metabolic processIDAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0051534negative regulation of NFAT protein import into nuIMPbiological_process
GO:0035372protein localization to microtubuleIEAbiological_process
GO:0045732positive regulation of protein catabolic processICbiological_process
GO:0006349regulation of gene expression by genetic imprintinIEAbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0030010establishment of cell polarityIEAbiological_process
GO:0010226response to lithium ionIEAbiological_process
GO:0002039p53 bindingIDAmolecular_function
GO:0016301kinase activityIDAmolecular_function
GO:0032092positive regulation of protein bindingISSbiological_process
GO:0031334positive regulation of protein complex assemblyIDAbiological_process
GO:0001837epithelial to mesenchymal transitionIMPbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0035255ionotropic glutamate receptor bindingIEAmolecular_function
GO:2000466negative regulation of glycogen (starch) synthase TASbiological_process
GO:0006983ER overload responseIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0006468protein phosphorylationIEAbiological_process
GO:0000320re-entry into mitotic cell cycleIEAbiological_process
GO:0045719negative regulation of glycogen biosynthetic proceTASbiological_process
GO:0051059NF-kappaB bindingIPImolecular_function
GO:0009887organ morphogenesisIEAbiological_process
GO:2000738positive regulation of stem cell differentiationIEAbiological_process
GO:0016310phosphorylationIEAbiological_process
GO:0048156tau protein bindingIEAmolecular_function
GO:0071109superior temporal gyrus developmentIMPbiological_process
GO:0043234protein complexIEAcellular_component
GO:0005813centrosomeIDAcellular_component
GO:0030877beta-catenin destruction complexIEAcellular_component
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0050321tau-protein kinase activityIEAmolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0032091negative regulation of protein bindingIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0090090negative regulation of canonical Wnt receptor signTASbiological_process
GO:0006983ER overload responseIDAbiological_process
GO:0044337canonical Wnt receptor signaling pathway involved IEAbiological_process
GO:0043198dendritic shaftIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0030529ribonucleoprotein complexIEAcellular_component
GO:0030877beta-catenin destruction complexIDAcellular_component
GO:0032886regulation of microtubule-based processIEAbiological_process
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0045444fat cell differentiationIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0045121membrane raftIEAcellular_component
GO:0031333negative regulation of protein complex assemblyIMPbiological_process
GO:0021766hippocampus developmentIMPbiological_process
GO:0007409axonogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0006950response to stressIEAbiological_process
GO:0032886regulation of microtubule-based processIMPbiological_process
GO:0018105peptidyl-serine phosphorylationIEAbiological_process
GO:0043227membrane-bounded organelleIEAcellular_component
GO:0042493response to drugIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005178integrin bindingIEAmolecular_function
GO:0050774negative regulation of dendrite morphogenesisIEAbiological_process
GO:0010800positive regulation of peptidyl-threonine phosphorIEAbiological_process
GO:0004674protein serine/threonine kinase activityISSmolecular_function
GO:0007520myoblast fusionIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0044027hypermethylation of CpG islandIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0032855positive regulation of Rac GTPase activityIMPbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0001954positive regulation of cell-matrix adhesionIMPbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0006611protein export from nucleusIEAbiological_process
GO:0001085RNA polymerase II transcription factor bindingIPImolecular_function
GO:0050321tau-protein kinase activityIDAmolecular_function