Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CAN2_HUMAN
Description:calpain 2, (m/II) large subunit [Source:HGNC Symbol;Acc:1479]
Location:chr1 q41
Node attribute:PPI(target); PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y611KYQKIyREIDVEF_hand_5PhosphoSitePlus
S369NWRRGsTAGGCPKA_groupphosphoELM; RegPhos
T370WRRGStAGGCRPKA_groupphosphoELM; RegPhos
Y353LTSDTyKKWKLPhosphoSitePlus
S369NWRRGsTAGGCCalpain_IIIPhosphoSitePlus
Y625GTMNSyEMRKAEF_hand_5PhosphoSitePlus
T464RERSDtFINLRCalpain_IIIPhosphoSitePlus
Y32YLNQDyEALRNPhosphoSitePlus
S50LFQDPsFPAIPErk1(MAPK3RegPhos
S50LFQDPsFPAIPPeptidase_C2PhosphoSitePlus
T370WRRGStAGGCRCalpain_IIIPhosphoSitePlus
T621VDRSGtMNSYEEF_hand_5PhosphoSitePlus
S50LFQDPsFPAIPMAPK3phosphoELM
S50LFQDPsFPAIPMAPK1phosphoELM
S586VDMLDsDGSGKEF_hand_6PhosphoSitePlus
S589LDSDGsGKLGLEF_hand_6PhosphoSitePlus
S50LFQDPsFPAIPErk2(MAPK1RegPhos

Dephosphorylation site
CAN2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000295006D529NBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000295006Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.1418646787
ENSP00000295006Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.118646787
ENSP00000295006Thyroid CarcinomaNormal vs. CancertissueUp2.517194741
ENSP00000295006Breast CancerNormal vs. Cancercell lineDown0.7420543960

Hyperphosphorylation site
CAN2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANCAN2_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANCAN2_HUMANkinase -> substrateRobert H Newman (2013)
CAN2_HUMANTLN1_HUMANotherKEGG
FAK1_HUMANCAN2_HUMANotherKEGG
GCFC2_HUMANCAN2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04210Apoptosis
hsa05010Alzheimer's disease
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0000785chromatinIEAcellular_component
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0001824blastocyst developmentIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0016540protein autoprocessingIEAbiological_process
GO:0004198calcium-dependent cysteine-type endopeptidase actiIEAmolecular_function
GO:0008233peptidase activityIEAmolecular_function
GO:0007520myoblast fusionIEAbiological_process
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0008234cysteine-type peptidase activityTASmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIEAcellular_component


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