Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:STA5A_HUMAN
Description:signal transducer and activator of transcription 5A [Source:HGNC Symbol;Acc:11366]
Location:chr17 q21.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S777MDSLDsRLSPPPhosphoSitePlus
T372PQVKAtIISEQRegPhos
Y90IKLGHyATQLQSTAT_intPhosphoSitePlus
Y694KAVDGyVKPQILynphosphoELM; RegPhos; SysPTM
Y90IKLGHyATQLQHPRD; phosphoELM; RegPhos
T372PQVKAtIISEQSTAT_bindPhosphoSitePlus
Y668LSYLIyVFPDRSH2PhosphoSitePlus
S726MDQAPsPAVCPPhosphoSitePlus; HPRD; RegPhos
Y694KAVDGyVKPQIBTKHPRD; RegPhos; SysPTM
S193QLAQLsPQERLSTAT_alphaPhosphoSitePlus; SysPTM
T647NLKPFtTRDFSSH2PhosphoSitePlus
S780LDSRLsPPAGLMAPK1phosphoELM
S780LDSRLsPPAGLMAPK3phosphoELM
S774RRPMDsLDSRLPhosphoSitePlus
Y22QMQVLyGQHFPSTAT_intPhosphoSitePlus
T92LGHYAtQLQKTSTAT_intPhosphoSitePlus
S375KATIIsEQQAKRegPhos
Y683VFSKYyTPVLAPhosphoSitePlus
S780LDSRLsPPAGLErk2(MAPK1RegPhos
S780LDSRLsPPAGLErk1(MAPK3RegPhos
Y694KAVDGyVKPQIPhosphoSitePlus; phosphoELM; SysPTM
T245LRKQQtIILDDSTAT_alphaPhosphoSitePlus
Y114IRHILyNEQRLSTAT_intPhosphoSitePlus
Y694KAVDGyVKPQIJAK2HPRD; phosphoELM; RegPhos; SysPTM
Y694KAVDGyVKPQIJAK1RegPhos; SysPTM
S193QLAQLsPQERLHPRD; phosphoELM; SysPTM
T648LKPFTtRDFSISH2PhosphoSitePlus
Y694KAVDGyVKPQISrcRegPhos; SysPTM
Y682EVFSKyYTPVLPhosphoSitePlus
Y694KAVDGyVKPQISRCphosphoELM; SysPTM
S375KATIIsEQQAKSTAT_bindPhosphoSitePlus
S780LDSRLsPPAGLPhosphoSitePlus; HPRD; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y694LAKAVDGyVKPQIKQPTPN11HPRD
Y694LAKAVDGyVKPQIKQPTPN1HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341208D658ECOSMICOvarian Cancer21720365
ENSP00000341208I28VDing2008, COSMICLung Cancer18948947

Differential expressed protein
STA5A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S780DSLDSRLsPPAGLFTacute lymphocytic leukemia; acute myelogenous leukemia; chronic myelogenous leukemia20508164PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANSTA5A_HUMANkinase -> substrateRegPhos
EGFR_HUMANSTA5A_HUMANkinase -> substrateKEGG
JAK1_HUMANSTA5A_HUMANkinase -> substrateRegPhos
JAK3_HUMANSTA5A_HUMANkinase -> substrateNetPath
MK03_HUMANSTA5A_HUMANkinase -> substrateRobert H Newman (2013)
ERBB4_HUMANSTA5A_HUMANkinase -> substrateKEGG
MK01_HUMANSTA5A_HUMANkinase -> substrateRobert H Newman (2013)
JAK2_HUMANSTA5A_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LYN_HUMANSTA5A_HUMANkinase -> substrateRobert H Newman (2013)
KIT_HUMANSTA5A_HUMANkinase -> substrateNetPath
BTK_HUMANSTA5A_HUMANkinase -> substrateHPRD; RegPhos
PTN11_HUMANSTA5A_HUMANphosphatase -> substrateHPRD; NetPath
PTN1_HUMANSTA5A_HUMANphosphatase -> substrateHPRD
STA5A_HUMANIGHE_HUMANTF -> target geneTRANSFAC
STA5A_HUMANSYWC_HUMANTF -> target geneTRANSFAC
STA5A_HUMANFCGR1_HUMANTF -> target geneTRANSFAC
STA5A_HUMANIL2RA_HUMANTF -> target geneTRANSFAC
STA5A_HUMANCCND1_HUMANTF -> target geneTRANSFAC
STA5A_HUMANIRF1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05203Viral carcinogenesis
hsa04630Jak-STAT signaling pathway
hsa05166HTLV-I infection
hsa05162Measles
hsa05221Acute myeloid leukemia
hsa04012ErbB signaling pathway
hsa05220Chronic myeloid leukemia

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033026negative regulation of mast cell apoptotic processIEAbiological_process
GO:0045931positive regulation of mitotic cell cycleIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0019218regulation of steroid metabolic processIEAbiological_process
GO:0007259JAK-STAT cascadeIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006631fatty acid metabolic processISSbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0045086positive regulation of interleukin-2 biosynthetic IEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0001553luteinizationIEAbiological_process
GO:0060376positive regulation of mast cell differentiationIEAbiological_process
GO:0045579positive regulation of B cell differentiationIEAbiological_process
GO:0061180mammary gland epithelium developmentIEAbiological_process
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0030155regulation of cell adhesionIEAbiological_process
GO:0045588positive regulation of gamma-delta T cell differenIEAbiological_process
GO:0030856regulation of epithelial cell differentiationIEAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0043029T cell homeostasisIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0032825positive regulation of natural killer cell differeIEAbiological_process
GO:0046543development of secondary female sexual characterisIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:00061032-oxoglutarate metabolic processISSbiological_process
GO:0042104positive regulation of activated T cell proliferatIEAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific IEAmolecular_function
GO:0007565female pregnancyIEAbiological_process
GO:0019915lipid storageIEAbiological_process
GO:0030879mammary gland developmentIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0045621positive regulation of lymphocyte differentiationIEAbiological_process
GO:0019530taurine metabolic processISSbiological_process
GO:0006549isoleucine metabolic processISSbiological_process
GO:0007595lactationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0040014regulation of multicellular organism growthISSbiological_process
GO:0060742epithelial cell differentiation involved in prostaIEAbiological_process
GO:0060740prostate gland epithelium morphogenesisIEAbiological_process
GO:0006573valine metabolic processISSbiological_process
GO:0045954positive regulation of natural killer cell mediateIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006107oxaloacetate metabolic processISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0040018positive regulation of multicellular organism growIEAbiological_process
GO:0000255allantoin metabolic processISSbiological_process
GO:0046449creatinine metabolic processISSbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0070668positive regulation of mast cell proliferationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0046544development of secondary male sexual characteristiIEAbiological_process
GO:0045647negative regulation of erythrocyte differentiationIEAbiological_process
GO:0006600creatine metabolic processISSbiological_process
GO:0006101citrate metabolic processISSbiological_process
GO:0006105succinate metabolic processISSbiological_process
GO:0008284positive regulation of cell proliferationIEAbiological_process