Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PYR1_HUMAN
Description:carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [Source:HGNC Symbol;Acc:1424]
Location:chr2 p23.3
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1037CRVLGtSPEAIP27708(Glutamine dependenRegPhos
S10VLEDGsVLRGQHPRD
Y1890PDGTCyPPPPVPhosphoSitePlus
Y2103RVSLRyVAPPSOTCacePhosphoSitePlus
S1406GGRRLsSFVTKphosphoELM
S1407GRRLSsFVTKGHPRD
T2155ERFGStQEYEAOTCacePhosphoSitePlus
T1914LLHPQtSPLLHPhosphoSitePlus
T456YFLPItPHYVTErk2RegPhos
S1061DTIGIsQPQWRCPSase_L_D2PhosphoSitePlus
Y267IGAKTyKMRYGGATasePhosphoSitePlus
T475DGVLLtFGGQTCPSase_L_chainPhosphoSitePlus
S1267KVPQFsFSRLAPhosphoSitePlus
T456YFLPItPHYVTMAPK1HPRD; phosphoELM
T456YFLPItPHYVTMAPK3phosphoELM
S1859RIHRAsDPGLPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T456YFLPItPHYVTErk1(MAPK3RegPhos
T166EVSIKtPRVFNPhosphoSitePlus
S1407GRRLSsFVTKGMGSPhosphoSitePlus
S1423LAADFsVPLIIMGSPhosphoSitePlus
S1222VRVSRsFPFVSCPSase_L_D2PhosphoSitePlus
S1920SPLLHsLVGQHHPRD; SysPTM
S1859RIHRAsDPGLPPKACaRegPhos; SysPTM
Y602WKEIEyEVVRDCPSase_L_D2PhosphoSitePlus
T456YFLPItPHYVTErk2(MAPK1RegPhos
S10VLEDGsVLRGQCPSase_sm_chainPhosphoSitePlus
S1900VPRQAsPQNLGPhosphoSitePlus; HPRD
T1833SEMTTtPERPRPhosphoSitePlus
S1406GGRRLsSFVTKPRKACAHPRD
Y735EPSVDyCVVKIPhosphoSitePlus
T456YFLPItPHYVTCPSase_L_chainPhosphoSitePlus
T1906PQNLGtPGLLHPhosphoSitePlus; HPRD
Y2212AENGMyIRMALOTCacePhosphoSitePlus
Y2158GSTQEyEACFGOTCacePhosphoSitePlus
Y1805LVPPGyGQDVRPhosphoSitePlus
S1406GGRRLsSFVTKMGSPhosphoSitePlus
S761GSCMKsVGEVMPhosphoSitePlus
S1823PQLPPsAPATSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S1859RIHRAsDPGLPPRKACAHPRD; SysPTM
T883LAVLStELAVRCPSase_L_D3PhosphoSitePlus
T1832TSEMTtTPERPPhosphoSitePlus
S1073LSDLEsARQFCHPRD
T504VRVLGtPVETICPSase_L_chainPhosphoSitePlus
S2154KERFGsTQEYEOTCacePhosphoSitePlus
Y1794RGEVAyIDGQVPhosphoSitePlus
S1406GGRRLsSFVTKPKACaRegPhos
S1423LAADFsVPLIIRegPhos
S1406GGRRLsSFVTKPKA_groupphosphoELM
S1828SAPATsEMTTTPhosphoSitePlus
S1938TKDQMsHLFNVOTCace_NPhosphoSitePlus
Y2203DPRAAyFRQAEOTCacePhosphoSitePlus
S1038RVLGTsPEAIDCPSase_L_chainPhosphoSitePlus; SysPTM
S1038RVLGTsPEAIDHPRD; SysPTM
T172PRVFNtGGAPRPhosphoSitePlus; HPRD
T1037CRVLGtSPEAICADHPRD
T2220MALLAtVLGRFOTCacePhosphoSitePlus
T1827PSAPAtSEMTTPhosphoSitePlus
S1220CNVRVsRSFPFCPSase_L_D2PhosphoSitePlus
T1831ATSEMtTTPERPhosphoSitePlus
T1884PELMGtPDGTCPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T375VRERLtERLCPHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1406GAGGRRLsSFVTKGYPPP1CAHPRD
S1859PPRIHRAsDPGLPAEPPP2CAHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000264705R1033QTCGAOvarian Cancer21720365, 18772890
ENSP00000264705R1403WCOSMICOvarian Cancer21720365
ENSP00000264705V823LTCGAOvarian Cancer21720365, 18772890
ENSP00000264705V823LCOSMICOvarian Cancer21720365
ENSP00000264705G1286ECOSMICPancreatic Cancer
ENSP00000264705T1239MTCGAOvarian Cancer21720365, 18772890
ENSP00000264705T1239MCOSMICOvarian Cancer21720365
ENSP00000264705Y735CSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000264705V1263LCOSMICRenal Cancer20054297
ENSP00000264705R177QSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000264705G322VCOSMICLung Cancer
ENSP00000264705R1033QCOSMICOvarian Cancer21720365
ENSP00000264705R1567WBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000264705M67ICOSMICOvarian Cancer21720365
ENSP00000264705R177QHPIColorectal Cancer16959974
ENSP00000264705Y735CHPIColorectal Cancer16959974
ENSP00000264705H458QBIOMARTBreast Cancer21930507, 21930502
ENSP00000264705M67ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000264705Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.518646787
ENSP00000264705Gastric CancerMetastasiscell lineUp2.217022644
ENSP00000264705Gastric CancerMetastasiscell lineUp2.217022644

Hyperphosphorylation site
PYR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPYR1_HUMANkinase -> substrateHPRD
MK03_HUMANPYR1_HUMANkinase -> substrateRobert H Newman (2013)
PYR1_HUMANPYR1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPYR1_HUMANkinase -> substrateRegPhos
MK01_HUMANPYR1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PP1A_HUMANPYR1_HUMANphosphatase -> substrateHPRD
PP2AA_HUMANPYR1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00250Alanine, aspartate and glutamate metabolism
hsa00240Pyrimidine metabolism
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007565female pregnancyIEAbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0007595lactationIEAbiological_process
GO:0042802identical protein bindingIEAmolecular_function
GO:0006207'de novo' pyrimidine nucleobase biosynthetic proceIEAbiological_process
GO:0016363nuclear matrixIDAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0004070aspartate carbamoyltransferase activityISSmolecular_function
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzinIEAmolecular_function
GO:0046134pyrimidine nucleoside biosynthetic processTASbiological_process
GO:0004070aspartate carbamoyltransferase activityIEAmolecular_function
GO:0016787hydrolase activityIEAmolecular_function
GO:0016810hydrolase activity, acting on carbon-nitrogen (butIEAmolecular_function
GO:0035690cellular response to drugIEAbiological_process
GO:0006541glutamine metabolic processIEAbiological_process
GO:0070335aspartate bindingISSmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0004672protein kinase activityISSmolecular_function
GO:0006543glutamine catabolic processIEAbiological_process
GO:0046777protein autophosphorylationISSbiological_process
GO:0044205'de novo' UMP biosynthetic processIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0042802identical protein bindingISSmolecular_function
GO:0006207'de novo' pyrimidine nucleobase biosynthetic proceISSbiological_process
GO:0006541glutamine metabolic processISSbiological_process
GO:0016597amino acid bindingIEAmolecular_function
GO:0042995cell projectionIEAcellular_component
GO:0017144drug metabolic processISSbiological_process
GO:0070409carbamoyl phosphate biosynthetic processIEAbiological_process
GO:0006807nitrogen compound metabolic processIEAbiological_process
GO:0009252peptidoglycan biosynthetic processIEAbiological_process
GO:0071364cellular response to epidermal growth factor stimuIEAbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0004151dihydroorotase activityISSmolecular_function
GO:0006520cellular amino acid metabolic processIEAbiological_process
GO:0006206pyrimidine nucleobase metabolic processTASbiological_process
GO:0005829cytosolIDAcellular_component
GO:0004151dihydroorotase activityIEAmolecular_function
GO:0051414response to cortisol stimulusIEAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0043195terminal buttonIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0014075response to amine stimulusIEAbiological_process
GO:0042995cell projectionISScellular_component
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzinISSmolecular_function
GO:0033574response to testosterone stimulusIEAbiological_process
GO:0008716D-alanine-D-alanine ligase activityIEAmolecular_function
GO:0016743carboxyl- or carbamoyltransferase activityIEAmolecular_function
GO:0043025neuronal cell bodyISScellular_component
GO:0018107peptidyl-threonine phosphorylationISSbiological_process
GO:0005524ATP bindingISSmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0017144drug metabolic processIEAbiological_process
GO:0055086nucleobase-containing small molecule metabolic proTASbiological_process
GO:0006228UTP biosynthetic processIEAbiological_process
GO:0043195terminal buttonISScellular_component
GO:0003824catalytic activityIEAmolecular_function
GO:0031000response to caffeineIEAbiological_process