Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTBP1_HUMAN
Description:polypyrimidine tract binding protein 1 [Source:HGNC Symbol;Acc:9583]
Location:chr19 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S459KDYGNsPLHRFHPRD
T22DELFStCVTNGPhosphoSitePlus
S16GTKRGsDELFSPhosphoSitePlus; phosphoELM; SysPTM
S272YNNDKsRDYTRPhosphoSitePlus
S16GTKRGsDELFSPRKACAHPRD; SysPTM
T446EDQGLtKDYGNHPRD
T427EDQGLtKDYGNPhosphoSitePlus; HPRD
S53KGDSRsAGVPSPhosphoSitePlus
S21SDELFsTCVTNPhosphoSitePlus
S141LKTDSsPNQARPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S16GTKRGsDELFSPKA_groupphosphoELM; RegPhos; SysPTM
S433KDYGNsPLHRFPhosphoSitePlus; HPRD; RegPhos; SysPTM
Y430GLTKDyGNSPLPhosphoSitePlus
S443FKKPGsKNFQNPhosphoSitePlus; HPRD
Y193VENLFyPVTLDPhosphoSitePlus
S16GTKRGsDELFSPKACaRegPhos; SysPTM
S469FKKPGsKNFQNHPRD
S462FKKPGsKNFQNHPRD
Y127RGQPIyIQFSNHPRD; phosphoELM; RegPhos
S140ELKTDsSPNQAPhosphoSitePlus; HPRD; SysPTM
S37SSNSAsAANGNHPRD
Y127RGQPIyIQFSNRRM_5PhosphoSitePlus
S452KDYGNsPLHRFHPRD
T453EDQGLtKDYGNHPRD
Y267SLNVKyNNDKSPhosphoSitePlus
T138HKELKtDSSPNPhosphoSitePlus; HPRD
S35IMSSNsASAANHPRD
S131IYIQFsNHKELRRM_5PhosphoSitePlus
T12DIAVGtKRGSDPhosphoSitePlus

Dephosphorylation site
PTBP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000349428T138ICOSMICSkin Cancer21984974
ENSP00000349428A311VTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000014112*532RCOSMICBreast Cancer20668451
ENSP00000014112*532RCOSMICBreast Cancer20668451
ENSP00000349428T71MCOSMICHead and Neck Cancer21984974
ENSP00000349428T71MCOSMICHead and Neck Cancer21984974
ENSP00000349428G310RCOSMICHead and Neck Cancer21798893
ENSP00000349428F222LCOSMICHead and Neck Cancer21798893
ENSP00000349428G310RCOSMICHead and Neck Cancer21798893
ENSP00000349428F222LCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000014112Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000014112Breast CancerTreatment (Antiestrogen-sensitive vs. Antiestrogen-resistant)cell lineUp14557597
ENSP00000014112Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.420804217
ENSP00000014112Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
PTBP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK9_HUMANPTBP1_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANPTBP1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANPTBP1_HUMANkinase -> substrateRegPhos
KPCA_HUMANPTBP1_HUMANkinase -> substrateHPRD
CDKL5_HUMANPTBP1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PTBP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033119negative regulation of RNA splicingIDAbiological_process
GO:0000398mRNA splicing, via spliceosomeTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005730nucleolusTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0036002pre-mRNA bindingIDAmolecular_function
GO:0006397mRNA processingTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0000381regulation of alternative mRNA splicing, via splicIDAbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0008187poly-pyrimidine tract bindingTASmolecular_function
GO:0048025negative regulation of mRNA splicing, via spliceosIDAbiological_process
GO:0051148negative regulation of muscle cell differentiationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0003723RNA bindingTASmolecular_function


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