Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARRB1_HUMAN
Description:arrestin, beta 1 [Source:HGNC Symbol;Acc:711]
Location:chr11 q13.4
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S412EDGTGsPQLNHPRD; phosphoELM; SysPTM
S86VANVQsFPPAPArrestin_NPhosphoSitePlus
Y54KERRVyVTLTCArrestin_NPhosphoSitePlus
S412EDGTGsPQLNMAPK1HPRD; SysPTM
S404EDGTGsPQLNMAPK1HPRD
T402EEEDGtGSPQLHPRD
S412EDGTGsPQLNMAPK3HPRD; SysPTM
S404EDGTGsPQLNMAPK3HPRD
Y144ACGVDyEVKAFArrestin_NPhosphoSitePlus
T410EEEDGtGSPQLHPRD; RegPhos
Y47LVDPEyLKERRArrestin_NPhosphoSitePlus
Y173IRKVQyAPERPArrestin_N; BatDPhosphoSitePlus
Y47LVDPEyLKERRRegPhos
S412EDGTGsPQLNNPhosphoSitePlus; RegPhos; SysPTM
S404EDGTGsPQLNHPRD
S412EDGTGsPQLNNErk2RegPhos; SysPTM
S412EDGTGsPQLNNErk1RegPhos; SysPTM
Y54KERRVyVTLTCSRCphosphoELM

Dephosphorylation site
ARRB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353124I231MBIOMARTBreast Cancer21930507, 21930502
ENSP00000409581I231MBIOMARTBreast Cancer21930507, 21930502
ENSP00000353124T298MCOSMICBreast Cancer20668451
ENSP00000353124T362RCOSMICBreast Cancer17932254

Differential expressed protein
ARRB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ARRB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANARRB1_HUMANkinase -> substrateRegPhos
MK03_HUMANARRB1_HUMANkinase -> substrateHPRD
MK01_HUMANARRB1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04062Chemokine signaling pathway
hsa05032Morphine addiction
hsa04144Endocytosis
hsa04744Phototransduction
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0016567protein ubiquitinationIMPbiological_process
GO:0006892post-Golgi vesicle-mediated transportTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0043547positive regulation of GTPase activityIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0004857enzyme inhibitor activityTASmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0032088negative regulation of NF-kappaB transcription facIDAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0005834heterotrimeric G-protein complexTAScellular_component
GO:0005096GTPase activator activityIMPmolecular_function
GO:0005829cytosolIEAcellular_component
GO:0043161proteasomal ubiquitin-dependent protein catabolic IMPbiological_process
GO:0006366transcription from RNA polymerase II promoterIMPbiological_process
GO:0044212transcription regulatory region DNA bindingIMPmolecular_function
GO:0016044cellular membrane organizationTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005765lysosomal membraneTAScellular_component
GO:0030659cytoplasmic vesicle membraneTAScellular_component
GO:0035774positive regulation of insulin secretion involved IEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIMPbiological_process
GO:0043149stress fiber assemblyIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0031434mitogen-activated protein kinase kinase bindingIEAmolecular_function
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0005159insulin-like growth factor receptor bindingIPImolecular_function
GO:0008134transcription factor bindingIPImolecular_function
GO:0043027cysteine-type endopeptidase inhibitor activity invIEAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0002031G-protein coupled receptor internalizationIMPbiological_process
GO:0032717negative regulation of interleukin-8 productionIDAbiological_process
GO:0090240positive regulation of histone H4 acetylationIMPbiological_process
GO:0030168platelet activationTASbiological_process
GO:0035066positive regulation of histone acetylationIMPbiological_process
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0031143pseudopodiumIEAcellular_component
GO:0032715negative regulation of interleukin-6 productionIDAbiological_process
GO:0005905coated pitIEAcellular_component
GO:0000139Golgi membraneTAScellular_component
GO:0000785chromatinIDAcellular_component
GO:0007219Notch signaling pathwayTASbiological_process
GO:0031701angiotensin receptor bindingIPImolecular_function
GO:0007602phototransductionIEAbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0043154negative regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0031397negative regulation of protein ubiquitinationIDAbiological_process
GO:0035025positive regulation of Rho protein signal transducIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0008277regulation of G-protein coupled receptor protein sIEAbiological_process