| UniProt/SwissProt ID: | RCAN1_HUMAN |
| Description: | regulator of calcineurin 1 [Source:HGNC Symbol;Acc:3040] |
| Location: | chr21 q22.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S32 | ISPPAsPPVGW | MAPK3 | HPRD |
| S28 | KQFLIsPPASP | GSK3B | HPRD |
| T208 | AATDTtPSVVV | Calcipressin | PhosphoSitePlus |
| S167 | ISPPAsPPVGW | Calcipressin | PhosphoSitePlus |
| T247 | RRPEYtPIHLS | PhosphoSitePlus | |
| S163 | VHVCEsDQEKE | GSK3B | RegPhos |
| S112 | ISPPAsPPVGW | MAPK_group | phosphoELM; RegPhos |
| S108 | KQFLIsPPASP | GSK3B | HPRD; RegPhos |
| S112 | ISPPAsPPVGW | Erk1 | RegPhos |
| S167 | ISPPAsPPVGW | MAPK3 | HPRD |
| Y188 | NYDLLyAISKL | Calcipressin | PhosphoSitePlus |
| S108 | KQFLIsPPASP | GSK_group | RegPhos |
| S108 | KQFLIsPPASP | GSK-3_group | phosphoELM |
| S163 | KQFLIsPPASP | GSK3B | HPRD |
| T179 | QVEDAtPVINY | Calcipressin | PhosphoSitePlus |
| Y94 | SLFRTyDKDIT | Calcipressin | PhosphoSitePlus |
| S112 | ISPPAsPPVGW | MAPK3 | HPRD |
| S163 | KQFLIsPPASP | Calcipressin | PhosphoSitePlus |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S28 | PDKQFLIsPPASPPV | PPP3CA | HPRD |
| S163 | PDKQFLIsPPASPPV | PPP3CA | HPRD |
| S108 | PDKQFLIsPPASPPV | PPP3CA | HPRD |
| Mutation site |
| RCAN1_HUMAN do not have mutation site. |
| Differential expressed protein |
| RCAN1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RCAN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GSK3B_HUMAN | RCAN1_HUMAN | kinase -> substrate | RegPhos |
| MK03_HUMAN | RCAN1_HUMAN | kinase -> substrate | HPRD |
| PP2BA_HUMAN | RCAN1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| RCAN1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0048741 | skeletal muscle fiber development | IEA | biological_process |
| GO:0009612 | response to mechanical stimulus | IEA | biological_process |
| GO:0019722 | calcium-mediated signaling | IEA | biological_process |
| GO:0043627 | response to estrogen stimulus | IEA | biological_process |
| GO:0007519 | skeletal muscle tissue development | IEA | biological_process |
| GO:0008015 | blood circulation | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | TAS | biological_process |
| GO:0003677 | DNA binding | TAS | molecular_function |
| GO:0051151 | negative regulation of smooth muscle cell differen | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007417 | central nervous system development | TAS | biological_process |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | IEA | biological_process |