Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GRB10_HUMAN
Description:growth factor receptor-bound protein 10 [Source:HGNC Symbol;Acc:4564]
Location:chr7 p12.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y9SLESLySACSMFYNHPRD
T155SPPVLtPGSLPPhosphoSitePlus
S372RKALLsPFSTPMAPK1HPRD
Y67SLESLySACSMFYNHPRD; RegPhos
S150LCGPGsPPVLTErk2RegPhos
S476ILGSQsPLHPSErk2(MAPK1RegPhos
S476ILGSQsPLHPSMAPK3phosphoELM
T364LSPFStPVRSVHPRD
Y404YGMLLyQNYRIPhosphoSitePlus; HPRD; phosphoELM
Y9SLESLySACSMSRCHPRD
S92LCGPGsPPVLTMAPK1HPRD
S474MNILGsQSPLHPhosphoSitePlus
S431SVSENsLVAMDRegPhos
S418RKALLsPFSTPPhosphoSitePlus; phosphoELM
S418RKALLsPFSTPErk2RegPhos
T376LSPFStPVRSVHPRD
Y67SLESLySACSMSRCHPRD; phosphoELM; RegPhos
S476ILGSQsPLHPSErk2RegPhos
S150LCGPGsPPVLTErk1(MAPK3RegPhos
S418ILGSQsPLHPSMAPK1HPRD
S430ILGSQsPLHPSMAPK1HPRD
S46IQPQVsPRQRVHPRD
S150LCGPGsPPVLTPhosphoSitePlus; RegPhos
S360RKALLsPFSTPMAPK1HPRD
S428PVRSVsENSLVBPSPhosphoSitePlus
S104IQPQVsPRQRVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S375LLSPFsTPVRSHPRD
T422LSPFStPVRSVPhosphoSitePlus; HPRD; phosphoELM
S150LCGPGsPPVLTErk2(MAPK1RegPhos
T178FSEDGtSKVVEHPRD
S476ILGSQsPLHPSMAPK1HPRD; phosphoELM
Y67SLESLySACSMPhosphoSitePlus
T120FSEDGtSKVVEHPRD
Y67SLESLySACSMSrcRegPhos
Y67SLESLySACSMFynphosphoELM; RegPhos
Y346YGMLLyQNYRIHPRD
S421LLSPFsTPVRSHPRD; phosphoELM
S476ILGSQsPLHPSPhosphoSitePlus; phosphoELM
S476ILGSQsPLHPSErk1(MAPK3RegPhos
S150LCGPGsPPVLTMAPK1HPRD; phosphoELM
S418RKALLsPFSTPMAPK1HPRD
S363LLSPFsTPVRSHPRD
S150LCGPGsPPVLTMAPK3phosphoELM
Y358YGMLLyQNYRIHPRD

Dephosphorylation site
GRB10_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381793A119VCOSMICHead and Neck Cancer21798893
ENSP00000381793V486MCOSMICLung Cancer20668451
ENSP00000385544Q2RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000381790Y194NBIOMARTBreast Cancer21930507, 21930502
ENSP00000381793Y252NBIOMARTBreast Cancer21930507, 21930502
ENSP00000385544Y246NBIOMARTBreast Cancer21930507, 21930502
ENSP00000385770A119VCOSMICHead and Neck Cancer21798893
ENSP00000385770K540ECOSMICLung Cancer20668451
ENSP00000349818Y252NBIOMARTBreast Cancer21930507, 21930502
ENSP00000338543Y194NBIOMARTBreast Cancer21930507, 21930502
ENSP00000381793P30TCOSMICLung Cancer20668451
ENSP00000381793A415TCOSMICSkin Cancer21984974
ENSP00000385046Y194NBIOMARTBreast Cancer21930507, 21930502
ENSP00000385770P30TCOSMICLung Cancer20668451
ENSP00000406716Y246NBIOMARTBreast Cancer21930507, 21930502
ENSP00000381793R520HCOSMICOvarian Cancer20668451
ENSP00000381793K540ECOSMICLung Cancer20668451
ENSP00000385770A415TCOSMICSkin Cancer21984974
ENSP00000385366Y194NBIOMARTBreast Cancer21930507, 21930502
ENSP00000385770V486MCOSMICLung Cancer20668451
ENSP00000385770R520HCOSMICOvarian Cancer20668451
ENSP00000385770Y252NBIOMARTBreast Cancer21930507, 21930502
ENSP00000385189Y194NBIOMARTBreast Cancer21930507, 21930502
ENSP00000385748Y194NBIOMARTBreast Cancer21930507, 21930502
ENSP00000406716Q2RBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
GRB10_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GRB10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANGRB10_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANGRB10_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANGRB10_HUMANkinase -> substrateRegPhos
SRC_HUMANGRB10_HUMANkinase -> substrateHPRD; RegPhos
FYN_HUMANGRB10_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
GRB10_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0030949positive regulation of vascular endothelial growthIDAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0042326negative regulation of phosphorylationIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0042327positive regulation of phosphorylationIEAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0046627negative regulation of insulin receptor signaling IEAbiological_process
GO:0046627negative regulation of insulin receptor signaling ISSbiological_process
GO:0032868response to insulin stimulusISSbiological_process
GO:0005158insulin receptor bindingISSmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0045719negative regulation of glycogen biosynthetic proceIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005070SH3/SH2 adaptor activityIEAmolecular_function
GO:0046325negative regulation of glucose importISSbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0046325negative regulation of glucose importIEAbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIDAbiological_process
GO:0048009insulin-like growth factor receptor signaling pathIEAbiological_process
GO:0005158insulin receptor bindingIEAmolecular_function


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