Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MKNK1_HUMAN
Description:MAP kinase interacting serine/threonine kinase 1 [Source:HGNC Symbol;Acc:7110]
Location:chr1 p33
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S460RGEDRsPPTALPhosphoSitePlus
S221NILCEsPEKVSPkinasePhosphoSitePlus
S413LNRQLsQHEENPhosphoSitePlus
S191PTSLGsSDPPTHPRD; RegPhos
T209CTPITtPELTTHPRD
T250CTPITtPELTTPkinasePhosphoSitePlus
S39GRATDsLPGKFPAK2HPRD; RegPhos
T255TPELTtPCGSAHPRD; RegPhos
S437CSMKLsPPCKSHPRD; RegPhos
S148NEREAsRVVRDPkinasePhosphoSitePlus
S237DFDLGsGMKLNPkinasePhosphoSitePlus
S460RGEDRsPPTHPRD; phosphoELM
T385EKGLPtPQVLQErk1RegPhos
T255TPELTtPCGSAPkinasePhosphoSitePlus
T250CTPITtPELTTHPRD; RegPhos
T214TPELTtPCGSAHPRD
T385EKGLPtPQVLQMAPK3HPRD; phosphoELM
T385EKGLPtPQVLQPhosphoSitePlus; RegPhos
T385EKGLPtPQVLQErk1(MAPK3RegPhos
S226SPEKVsPVKICPkinasePhosphoSitePlus
S393VLQRNsSTMDLPhosphoSitePlus

Dephosphorylation site
MKNK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361014T254SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000361014N216IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
MKNK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MKNK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANMKNK1_HUMANkinase -> substrateRegPhos
MKNK1_HUMANIF4B_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
PAK2_HUMANMKNK1_HUMANkinase -> substrateHPRD; RegPhos
MKNK1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANGEMI7_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANMKNK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MKNK1_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANIF4E_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
MKNK1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANPA24A_HUMANkinase -> substrateHPRD; RegPhos
MKNK1_HUMANIF4A2_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANUHMK1_HUMANkinase -> substrateRobert H Newman (2013)
MKNK1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0016020membraneIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0009103lipopolysaccharide biosynthetic processIEAbiological_process
GO:0006417regulation of translationIEAbiological_process


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