Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:GAB1_HUMAN
Description:GRB2-associated binding protein 1 [Source:HGNC Symbol;Acc:4066]
Location:chr4 q31.21
Node attribute:PPI(source); substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y447ELDENyVPMNPInsRRegPhos
S664DLDLDsGKSTPHPRD
T476NYVPMtPGTFDMAPK3HPRD
Y472IQEANyVPMTPEGFRHPRD; phosphoELM; RegPhos
S637LDSGKsTPPRKPhosphoSitePlus; HPRD
S597SRFPMsPRPDSMAPK3HPRD
S597SRFPMsPRPDSMAPK1HPRD
S551QAPVRsPITRSPhosphoSitePlus
S683TDGRQsTESETPhosphoSitePlus
S419SDRSSsLEGFHPhosphoSitePlus
Y285ADGELyVFNTPEGFRHPRD; phosphoELM; RegPhos
S567SRFPMsPRPDSMAPK3HPRD
Y405ASSQDcYDIPRHPRD
S567SRFPMsPRPDSMAPK1HPRD
S355PAHDRsPVETCPhosphoSitePlus; HPRD
Y373DTDSSyCIPTAEGFRHPRD; phosphoELM; RegPhos
Y627DKQVEyLDLDLInsRRegPhos
Y285ADGELyVFNTPMetphosphoELM; RegPhos
T684DGRQStESETPPhosphoSitePlus
Y373DTDSSyCIPTAINSRHPRD; phosphoELM; RegPhos
Y447ELDENyVPMNPEGFRHPRD; phosphoELM; RegPhos
Y589DSEENyVPMNPInsRRegPhos
Y259VDSSLyNLPRSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y307HVSISyDIPPTPhosphoSitePlus
Y657DKQVEyLDLDLMETHPRD
Y619DSEENyVPMNPMETHPRD
S551QAPVRsPITRSErk1RegPhos
S551QAPVRsPITRSErk2RegPhos
Y689DERVDyVVVDQINSRHPRD
Y659DERVDyVVVDQEGFRHPRD; phosphoELM; RegPhos; SysPTM
T476NYVPMtPGTFDMAPK1HPRD; phosphoELM
S381PTAGMsPSRSNPhosphoSitePlus
Y285ADGELyVFNTPPhosphoSitePlus; phosphoELM
Y589DSEENyVPMNPINSRHPRD; phosphoELM; RegPhos
Y659DERVDyVVVDQMetphosphoELM; RegPhos; SysPTM
S402RKDASsQDCYDPhosphoSitePlus
T503RSSPKtPPRRPRegPhos
Y373DTDSSyCIPTAMetphosphoELM; RegPhos
Y659DERVDyVVVDQMETHPRD; RegPhos; SysPTM
Y472IQEANyVPMTPMetphosphoELM; RegPhos
Y83EFENSyIFDINPHPhosphoSitePlus
S418PSDRSsSLEGFPhosphoSitePlus
T387PSRSNtISTVDPhosphoSitePlus
S551QAPVRsPITRSMAPK3HPRD
S551QAPVRsPITRSMAPK1HPRD
Y406SSQDCyDIPRAEGFRHPRD; phosphoELM; RegPhos
Y48DVLEYyKNDHAPHPhosphoSitePlus
Y472IQEANyVPMTPINSRHPRD; phosphoELM; RegPhos
Y373DTDSSyCIPTAMETHPRD; RegPhos
T476NYVPMtPGTFDErk2RegPhos
T476NYVPMtPGTFDErk1RegPhos
Y472IQEANyVPMTPMETHPRD; RegPhos
T312YDIPPtPGNTYPhosphoSitePlus
S244QMIYDsPPSRAPhosphoSitePlus
Y472IQEANyVPMTPPhosphoSitePlus
Y659DERVDyVVVDQINSRHPRD; RegPhos; SysPTM
Y406SSQDCyDIPRAMETHPRD; RegPhos
Y406SSQDCyDIPRAPhosphoSitePlus; phosphoELM
T476NYVPMtPGTFDPhosphoSitePlus
Y183EDPQDyLLLINPhosphoSitePlus
Y659DERVDyVVVDQPhosphoSitePlus; phosphoELM; SysPTM
T476NYVPMtPGTFDErk2(MAPK1RegPhos
S383AGMSPsRSNTIPhosphoSitePlus
Y47PDVLEyYKNDHPHPhosphoSitePlus
S547LERTDsQTIGDHPRD
Y406SSQDCyDIPRAMetphosphoELM; RegPhos
S581QAPVRsPITRSMAPK1HPRD
S581QAPVRsPITRSMAPK3HPRD
Y242QQQMIyDSPPSINSRHPRD; phosphoELM; RegPhos
Y265NLPRSySHDVLPhosphoSitePlus
Y447ELDENyVPMNPINSRHPRD; phosphoELM; RegPhos
T312YDIPPtPGNTYMAPK1HPRD
T312YDIPPtPGNTYMAPK3HPRD
Y688ADERVdYVVVDHPRD
S634DLDLDsGKSTPPhosphoSitePlus; HPRD
S454PMNPNsPPRQHErk1RegPhos
Y627DKQVEyLDLDLEGFRHPRD; phosphoELM; RegPhos
S381PTAGMsPSRSNErk1RegPhos
S454PMNPNsPPRQHMAPK1HPRD
S454PMNPNsPPRQHMAPK3HPRD
Y317TPGNTyQIPRTPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S257ASVDSsLYNLPPhosphoSitePlus
S381PTAGMsPSRSNErk2RegPhos
S567SRFPMsPRPDSErk1RegPhos
S567SRFPMsPRPDSErk2RegPhos
Y619DSEENyVPMNPINSRHPRD
Y447ELDENyVPMNPMetphosphoELM; RegPhos
Y373DTDSSyCIPTAPhosphoSitePlus; phosphoELM
S371ASDTDsSYCIPPhosphoSitePlus
Y447ELDENyVPMNPMETHPRD; RegPhos
S253RAPSAsVDSSLPhosphoSitePlus
Y307HVSISyDIPPTEGFRHPRD; phosphoELM; RegPhos
S401LRKDAsSQDCYPhosphoSitePlus
S306RHVSIsYDIPPPhosphoSitePlus
S372SDTDSsYCIPTPhosphoSitePlus
S266LPRSYsHDVLPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y285ADGELyVFNTPINSRHPRD; RegPhos
Y657DKQVEyLDLDLINSRHPRD
Y657DKQVEyLDLDLEGFRHPRD
T365CSIPRtASDTDPhosphoSitePlus
Y242QQQMIyDSPPSInsRRegPhos
Y658ADERVdYVVVDHPRD
Y689DERVDyVVVDQEGFRHPRD
Y589DSEENyVPMNPEGFRHPRD; phosphoELM; RegPhos
S667LDSGKsTPPRKHPRD
Y589DSEENyVPMNPPhosphoSitePlus
Y307HVSISyDIPPTMETHPRD; RegPhos
Y242QQQMIyDSPPSPhosphoSitePlus
T316PTPGNtYQIPRPhosphoSitePlus
T638DSGKStPPRKQPhosphoSitePlus
Y627DKQVEyLDLDLINSRHPRD; phosphoELM; RegPhos
S256SASVDsSLYNLPhosphoSitePlus
S454PMNPNsPPRQHErk2RegPhos
Y589DSEENyVPMNPMetphosphoELM; RegPhos
Y307HVSISyDIPPTMetphosphoELM; RegPhos
Y447ELDENyVPMNPPhosphoSitePlus
Y589DSEENyVPMNPMETHPRD; RegPhos
T369RTASDtDSSYCPhosphoSitePlus
Y472IQEANyVPMTPInsRRegPhos
Y619DSEENyVPMNPEGFRHPRD
S381PTAGMsPSRSNMAPK3HPRD
S381PTAGMsPSRSNMAPK1HPRD
Y689DERVDyVVVDQMETHPRD
Y373DTDSSyCIPTAInsRRegPhos
S597MNPNLsSEDPNErk2RegPhos
S597MNPNLsSEDPNErk1RegPhos
Y285ADGELyVFNTPMETHPRD; RegPhos
S304QMRHVsISYDIPhosphoSitePlus
Y627DKQVEyLDLDLPhosphoSitePlus; phosphoELM
Y627DKQVEyLDLDLMetphosphoELM; RegPhos
T312YDIPPtPGNTYErk1RegPhos
T312YDIPPtPGNTYErk2RegPhos
Y627DKQVEyLDLDLMETHPRD; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y657KGDKQVEyLDLDLDSPTPN11HPRD
Y627KGDKQVEyLDLDLDSPTPN11HPRD
Y659VADERVDyVVVDQQKPTPN11HPRD
Y589SHDSEENyVPMNPNLPTPN11HPRD
Y689VADERVDyVVVDQQKPTPN11HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262995Y83CCOSMICBreast Cancer16959974
ENSP00000262994Y83CSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000262995S615RCOSMICHead and Neck Cancer21798893
ENSP00000262995K398ICOSMICMelanoma21499247
ENSP00000262995R498MCOSMICLung Cancer
ENSP00000262994T387NSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502
ENSP00000262995T387NCOSMICBreast Cancer16959974
ENSP00000262995H426NCOSMICSkin Cancer21984974

Differential expressed protein
GAB1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
GAB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANGAB1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANGAB1_HUMANkinase -> substrateRegPhos
INSR_HUMANGAB1_HUMANkinase -> substrateRegPhos
SLTM_HUMANGAB1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK01_HUMANGAB1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
EGFR_HUMANGAB1_HUMANkinase -> substrateRegPhos
PTN11_HUMANGAB1_HUMANphosphatase -> substrateHPRD
GAB1_HUMANPI3R5_HUMANotherKEGG
GRB2_HUMANGAB1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05100Bacterial invasion of epithelial cells
hsa04722Neurotrophin signaling pathway
hsa04012ErbB signaling pathway
hsa05211Renal cell carcinoma

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007257activation of JUN kinase activityIEAbiological_process
GO:0030334regulation of cell migrationIEAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0070102interleukin-6-mediated signaling pathwayIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0006979response to oxidative stressIEAbiological_process
GO:0004871signal transducer activityIEAmolecular_function
GO:0060711labyrinthine layer developmentIEAbiological_process
GO:0043410positive regulation of MAPK cascadeIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0008544epidermis developmentIEAbiological_process
GO:0000187activation of MAPK activityIEAbiological_process


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