Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRBP1_HUMAN
Description:sterol regulatory element binding transcription factor 1 [Source:HGNC Symbol;Acc:11289]
Location:chr17 p11.2
Node attribute:PPI(target); PPI(source); substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y567VLLFVyGEPVTTMPhosphoSitePlus
S117SMPAFsPGPGIErk2(MAPK1RegPhos
S434PSDAGsPFQSSPhosphoSitePlus
S312RLAAGsKAPASPhosphoSitePlus
S439SPFQSsPLSLGCDK1phosphoELM
S63GTDPAsPDTSSPhosphoSitePlus
S478LGSRGsGSGGSHPRD
S1049FQRDLsSLRRLHPRD
S1049LMAGAsPTRTHPhosphoSitePlus
S396VHKSKsLKDLVDUF904PhosphoSitePlus
S117SMPAFsPGPGIErk1RegPhos
S117SMPAFsPGPGIMAPK3HPRD; phosphoELM
S117SMPAFsPGPGIMAPK1HPRD; phosphoELM
S117SMPAFsPGPGIErk2RegPhos
T426VEDTLtPPPSDPhosphoSitePlus
T275LVSGTtVQTGPDUF1646PhosphoSitePlus
S448LGSRGsGSGGSHPRD; phosphoELM
S1020QRDLSsLRRLAHPRD; RegPhos
S1019FQRDLsSLRRLHPRD; RegPhos
Y110TPLKMyPSMPARegPhos
S450SRGSGsGGSGSHPRD; phosphoELM
S338KRYRSsINDKIHLHPhosphoSitePlus
S480SRGSGsGGSGSHPRD
S430LTPPPsDAGSPPhosphoSitePlus
S117SMPAFsPGPGIPhosphoSitePlus; phosphoELM
S147SMPAFsPGPGIMAPK1HPRD
S147SMPAFsPGPGIMAPK3HPRD
S439SPFQSsPLSLGPhosphoSitePlus
S1050QRDLSsLRRLAHPRD
S117SMPAFsPGPGIErk1(MAPK3RegPhos

Dephosphorylation site
SRBP1_HUMAN do not have dephosphorylation site.

Mutation site
SRBP1_HUMAN do not have mutation site.

Differential expressed protein
SRBP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SRBP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANSRBP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANSRBP1_HUMANkinase -> substrateRegPhos
MK03_HUMANSRBP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
SRBP1_HUMANKPYR_HUMANotherKEGG
SRBP1_HUMANACACA_HUMANotherKEGG
SRBP1_HUMANFAS_HUMANotherKEGG
KPCI_HUMANSRBP1_HUMANotherKEGG
SRBP1_HUMANM4K2_HUMANotherKEGG
SRBP1_HUMANPPARG_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045542positive regulation of cholesterol biosynthetic prIEAbiological_process
GO:0033993response to lipidIEAbiological_process
GO:0046676negative regulation of insulin secretionIEAbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0046983protein dimerization activityIEAmolecular_function
GO:0032869cellular response to insulin stimulusIEAbiological_process
GO:0032933SREBP signaling pathwayIEAbiological_process
GO:0012507ER to Golgi transport vesicle membraneIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032526response to retinoic acidIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043234protein complexIEAcellular_component
GO:0032094response to foodIEAbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0031065positive regulation of histone deacetylationIEAbiological_process
GO:0050796regulation of insulin secretionIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0019217regulation of fatty acid metabolic processIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0044444cytoplasmic partIEAcellular_component
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0033762response to glucagon stimulusIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0000139Golgi membraneIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0009267cellular response to starvationIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005635nuclear envelopeTAScellular_component
GO:0008610lipid biosynthetic processIEAbiological_process
GO:0070542response to fatty acidIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0032570response to progesterone stimulusIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0032403protein complex bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0051591response to cAMPIEAbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0019901protein kinase bindingIEAmolecular_function
GO:0003062regulation of heart rate by chemical signalIEAbiological_process
GO:0010867positive regulation of triglyceride biosynthetic pIEAbiological_process
GO:0032810sterol response element bindingIDAmolecular_function