Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:THB_HUMAN
Description:thyroid hormone receptor, beta [Source:HGNC Symbol;Acc:11799]
Location:chr3 p24.2
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S142KNLHPsYSCKYMAPK1phosphoELM
S142KNLHPsYSCKYzf-C4PhosphoSitePlus
Y406LAFEHyINYRKHormone_recepPhosphoSitePlus
Y171FKKCIyVGMATzf-C4PhosphoSitePlus
S142KNLHPsYSCKYErk1(MAPK3RegPhos
S142KNLHPsYSCKYErk2(MAPK1RegPhos
S142KNLHPsYSCKYMAPK3phosphoELM
S270DLEAFsHFTKIHormone_recepPhosphoSitePlus

Dephosphorylation site
THB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000414444T134ICOSMICMelanoma
ENSP00000414444T48MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379904T134ICOSMICMelanoma
ENSP00000348827T134ICOSMICMelanoma
ENSP00000388467T48MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000348827T48MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000379904T48MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000404898T48MBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
THB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
THB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANTHB_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANTHB_HUMANkinase -> substrateRobert H Newman (2013)
THB_HUMANGLHA_HUMANTF -> target geneTRANSFAC
THB_HUMANEGFR_HUMANTF -> target geneTRANSFAC
THB_HUMANTSHB_HUMANTF -> target geneTRANSFAC
THB_HUMANMYH6_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
THB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0005634nucleusTAScellular_component
GO:0008016regulation of heart contractionIEAbiological_process
GO:0004887thyroid hormone receptor activityIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorNASmolecular_function
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0008050female courtship behaviorIEAbiological_process
GO:0031490chromatin DNA bindingIEAmolecular_function
GO:0019899enzyme bindingIPImolecular_function
GO:0007621negative regulation of female receptivityIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003714transcription corepressor activityTASmolecular_function
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003677DNA bindingTASmolecular_function
GO:0007605sensory perception of soundIEAbiological_process


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