Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TFE2_HUMAN
Description:transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) [Source:HGNC Symbol;Acc:11633]
Location:chr19 p13.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S351SNNFSsSPSTPPhosphoSitePlus
S134ELALNsPGPLSPhosphoSitePlus; HPRD
T355SSSPStPVGSPMAPK_groupphosphoELM; RegPhos
Y149KGTSQyYPSYSPhosphoSitePlus
T355SSSPStPVGSPPhosphoSitePlus
S367GLAGTsQWPRAPhosphoSitePlus
Y153QYYPSySGSSRPhosphoSitePlus
S245LGGGSsPLPLPPhosphoSitePlus
S354FSSSPsTPVGSPhosphoSitePlus
S514SAADHsEEEKKHPRD
S350SSNNFsSSPSTPhosphoSitePlus
S139SPGPLsPSGMKPhosphoSitePlus; HPRD
S346SPDHSsNNFSSPhosphoSitePlus
S381GALSPsYDGGLPhosphoSitePlus; HPRD; phosphoELM
Y382ALSPSyDGGLHPhosphoSitePlus; HPRD; phosphoELM
S341LASIYsPDHSSPhosphoSitePlus
T366QGLAGtSQWPRPhosphoSitePlus
S39KGRPAsLAGAQPhosphoSitePlus
Y108GERGAyASFGRPhosphoSitePlus
T355SSSPStPVGSPErk1RegPhos
T355SSSPStPVGSPErk2RegPhos
S306YGGVSsHTPPVHPRD
S352NNFSSsPSTPVPhosphoSitePlus
T411SHAVGtAGDMHPhosphoSitePlus
S529PRARTsPDEDEphosphoELM
T355SSSPStPVGSPMAPK1HPRD
T355SSSPStPVGSPMAPK3HPRD
S379APGALsPSYDGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y150GTSQYyPSYSGPhosphoSitePlus
S359STPVGsPQGLAPhosphoSitePlus
S345YSPDHsSNNFSPhosphoSitePlus

Dephosphorylation site
TFE2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262965A8VHPIColorectal Cancer16959974
ENSP00000262965T491MCOSMICSkin Cancer21984974
ENSP00000262965A8VSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000262965V10LCOSMICLung Cancer20668451
ENSP00000262965E545KCOSMICLung Cancer20668451
ENSP00000262965D218ECOSMICBreast Cancer20668451
ENSP00000262965P633LCOSMICOvarian Cancer20668451

Differential expressed protein
TFE2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TFE2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANTFE2_HUMANkinase -> substrateHPRD; NetPath
MK01_HUMANTFE2_HUMANkinase -> substrateHPRD; NetPath
CDK6_HUMANTFE2_HUMANkinase -> substrateRobert H Newman (2013)
FGFR2_HUMANTFE2_HUMANkinase -> substrateRobert H Newman (2013)
TFE2_HUMANGLI1_HUMANTF -> target geneTRANSFAC
TFE2_HUMANNR0B2_HUMANTF -> target geneTRANSFAC
TFE2_HUMANFOS_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05202Transcriptional misregulation in cancer
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0070888E-box bindingISSmolecular_function
GO:0043425bHLH transcription factor bindingIPImolecular_function
GO:0030183B cell differentiationNASbiological_process
GO:0043967histone H4 acetylationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005667transcription factor complexIDAcellular_component
GO:0045787positive regulation of cell cycleIDAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0050821protein stabilizationIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0005667transcription factor complexIEAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenISSbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0046983protein dimerization activityIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIDAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0003713transcription coactivator activityIDAmolecular_function
GO:0043234protein complexIDAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0002326B cell lineage commitmentNASbiological_process
GO:0006351transcription, DNA-dependentIDAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0051149positive regulation of muscle cell differentiationTASbiological_process
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0048468cell developmentIEAbiological_process
GO:0033152immunoglobulin V(D)J recombinationIDAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0030098lymphocyte differentiationIEAbiological_process
GO:0010628positive regulation of gene expressionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0008134transcription factor bindingIPImolecular_function
GO:0045944positive regulation of transcription from RNA polyISSbiological_process
GO:0042692muscle cell differentiationTASbiological_process
GO:0070644vitamin D response element bindingIDAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0045666positive regulation of neuron differentiationISSbiological_process
GO:0000788nuclear nucleosomeIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0031435mitogen-activated protein kinase kinase kinase binIPImolecular_function
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001779natural killer cell differentiationIEAbiological_process
GO:0043966histone H3 acetylationIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0033152immunoglobulin V(D)J recombinationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0000080G1 phase of mitotic cell cycleIDAbiological_process
GO:0030890positive regulation of B cell proliferationIMPbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0070491repressing transcription factor bindingIPImolecular_function