Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCDC6_HUMAN
Description:coiled-coil domain containing 6 [Source:HGNC Symbol;Acc:18782]
Location:chr10 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S362TPSPSsSRPISPhosphoSitePlus; HPRD; phosphoELM
T383GFTPPtSLTRAPhosphoSitePlus
S350LRPRTvSSPIPHPRD
Y393AGMSYyNSPGLPhosphoSitePlus
S249SPRDIsMEIDSHPRD; phosphoELM
S406QHMGTsHGITRPhosphoSitePlus
S328SESESsLEMDDDUF2046PhosphoSitePlus
S359IPYTPsPSSSRPhosphoSitePlus; phosphoELM
S418SPRRSnSPDKFHPRD
S249SPRDIsMEIDSDUF2046PhosphoSitePlus
S327LSESEsSLEMDDUF2046PhosphoSitePlus
S284AQLQHsEKMAQDUF2046PhosphoSitePlus
Y336MDDERyFNEMSDUF2046PhosphoSitePlus
Y290EKMAQyLEEERDUF2046PhosphoSitePlus
T380HTVGFtPPTSLPhosphoSitePlus; HPRD; phosphoELM
T386PPTSLtRAGMSPhosphoSitePlus; HPRD
S325RQLSEsESSLEDUF2046PhosphoSitePlus
T349GLRPRtVSSPIPhosphoSitePlus; HPRD; phosphoELM
S361YTPSPsSSRPIPhosphoSitePlus; HPRD; phosphoELM
S65TNRLAsLQQENDUF2046; bZIP_1PhosphoSitePlus
T115EFISNtLFKKIDUF2046PhosphoSitePlus
S244VSAPPsPRDISMAPK3HPRD
S323LCRQLsESESSDUF2046PhosphoSitePlus
S395MSYYNsPGLHVPhosphoSitePlus; HPRD
S284AQLQHsEKMAQHPRD
T185KLENDtISKQLHPRD
S431PTPPPsPNTQTHPRD
S363PSPSSsRPISPPhosphoSitePlus; HPRD; phosphoELM
Y356SSPIPyTPSPSPhosphoSitePlus; HPRD; phosphoELM
S413GITRPsPRRSNPhosphoSitePlus; HPRD
Y392RAGMSyYNSPGPhosphoSitePlus
T434PPSPNtQTPVQPhosphoSitePlus
S352PRTVSsPIPYTPhosphoSitePlus; HPRD; phosphoELM
S243PVSAPpSPRDIHPRD
S46GGGGKsGGIVIDUF2046PhosphoSitePlus
S254SMEIDsPENMMDUF2046PhosphoSitePlus
S323LCRQLsESESSHPRD; RegPhos
T79KIELEtYKLKCDUF2046; bZIP_1PhosphoSitePlus
S391TRAGMsYYNSPPhosphoSitePlus; HPRD
T115EFISNtLFKKIHPRD; phosphoELM; RegPhos
S46GGGGKsGGIVIHPRD
S244VSAPPsPRDISDUF2046PhosphoSitePlus
S52GGIVIsPFRLEHPRD; phosphoELM; RegPhos
S351RPRTVsSPIPYPhosphoSitePlus; HPRD; phosphoELM
T376SYASHtVGFTPPhosphoSitePlus; HPRD; phosphoELM
S472SAHPSsHPRD
T427KFKRPtPPPSPPhosphoSitePlus
T357SPIPYtPSPSSPhosphoSitePlus; phosphoELM
S384FTPPTsLTRAGPhosphoSitePlus
S244VSAPPsPRDISErk1RegPhos
Y372SPGLSyASHTVPhosphoSitePlus; HPRD; phosphoELM
S367SSRPIsPGLSYPhosphoSitePlus; HPRD; phosphoELM
S52GGIVIsPFRLEDUF2046PhosphoSitePlus
S113EEEFIsNTLFKDUF2046PhosphoSitePlus
S325RQLSEsESSLEHPRD; RegPhos
S244VSAPPsPRDISphosphoELM; RegPhos
S374GLSYAsHTVGFPhosphoSitePlus
S371ISPGLsYASHTPhosphoSitePlus; HPRD; phosphoELM
S240LDQPVsAPPSPHPRD; phosphoELM; RegPhos
S419PRRSNsPDKFKPhosphoSitePlus; HPRD; phosphoELM
S254SMEIDsPENMMHPRD; phosphoELM
S328SESESsLEMDDHPRD; RegPhos
S240LDQPVsAPPSPDUF2046PhosphoSitePlus
S65TNRLAsLQQENHPRD

Dephosphorylation site
CCDC6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263102P442SCOSMICOvarian Cancer21720365
ENSP00000263102L217PCOSMICOvarian Cancer21720365
ENSP00000263102A226SCOSMICOvarian Cancer21720365

Differential expressed protein
CCDC6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCDC6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCCDC6_HUMANkinase -> substrateRegPhos
MK03_HUMANCCDC6_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05200Pathways in cancer
hsa05216Thyroid cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005200structural constituent of cytoskeletonTASmolecular_function
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0008150biological_processNDbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005856cytoskeletonIEAcellular_component


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