Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KAPCB_HUMAN
Description:protein kinase, cAMP-dependent, catalytic, beta [Source:HGNC Symbol;Acc:9381]
Location:chr1 p31.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y69KATEQyYAMKIPkinase_AGCPhosphoSitePlus
T243RVKGRtWTLCGHPRD
T196RVKGRtWTLCGHPRD
S386EDIRVsITEKCHPRD
T198KGRTWtLCGTPHPRD
T202WTLCGtPEYLAPkinase_AGCPhosphoSitePlus
T325RGSGDtSNFDDPhosphoSitePlus
S339EDIRVsITEKCPhosphoSitePlus; HPRD
T341IRVSItEKCAKPhosphoSitePlus
T196RVKGRtWTLCGPkinase_AGCPhosphoSitePlus
S322PKFRGsGDTSNPhosphoSitePlus
S326GSGDTsNFDDYPhosphoSitePlus
Y205CGTPEyLAPEIPkinase_AGCPhosphoSitePlus
Y331SNFDDyEEEDIPhosphoSitePlus
T245KGRTWtLCGTPHPRD
T52KKTLGtGSFGRPkinase_AGCPhosphoSitePlus
Y70ATEQYyAMKILPkinase_AGCPhosphoSitePlus
T198KGRTWtLCGTPPkinase_AGCPhosphoSitePlus

Dephosphorylation site
KAPCB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359719E79DDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000359719D123YDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000359719A3SDing2008, COSMICLung Cancer18948947

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000359723Breast CancerNormal vs. CancertissueUp0.4420739354

Hyperphosphorylation site
KAPCB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A5_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
KAPCB_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KAPCB_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
DYR1B_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
KAPCB_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
BMR1A_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
KAPCB_HUMANTNR16_HUMANkinase -> substrateHPRD
GSK3B_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
KAPCB_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
KAPCB_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
PRKX_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
MK03_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
DCLK1_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANKAPCB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04740Olfactory transduction
hsa05166HTLV-I infection
hsa05032Morphine addiction
hsa04728Dopaminergic synapse
hsa04720Long-term potentiation
hsa04961Endocrine and other factor-regulated calcium reabs
hsa04912GnRH signaling pathway
hsa04976Bile secretion
hsa05020Prion diseases
hsa04723Retrograde endocannabinoid signaling
hsa05146Amoebiasis
hsa05414Dilated cardiomyopathy
hsa04062Chemokine signaling pathway
hsa04724Glutamatergic synapse
hsa04270Vascular smooth muscle contraction
hsa04020Calcium signaling pathway
hsa04340Hedgehog signaling pathway
hsa04742Taste transduction
hsa04210Apoptosis
hsa04725Cholinergic synapse
hsa04010MAPK signaling pathway
hsa05031Amphetamine addiction
hsa04962Vasopressin-regulated water reabsorption
hsa04916Melanogenesis
hsa04971Gastric acid secretion
hsa04727GABAergic synapse
hsa05169Epstein-Barr virus infection
hsa05030Cocaine addiction
hsa04970Salivary secretion
hsa04914Progesterone-mediated oocyte maturation
hsa05110Vibrio cholerae infection
hsa05203Viral carcinogenesis
hsa04540Gap junction
hsa04726Serotonergic synapse
hsa04310Wnt signaling pathway
hsa04114Oocyte meiosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006094gluconeogenesisTASbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recTASbiological_process
GO:0097338response to clozapineIEAbiological_process
GO:0031625ubiquitin protein ligase bindingIDAmolecular_function
GO:0005952cAMP-dependent protein kinase complexIEAcellular_component
GO:0004691cAMP-dependent protein kinase activityIDAmolecular_function
GO:0005952cAMP-dependent protein kinase complexTAScellular_component
GO:0019433triglyceride catabolic processTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0034199activation of protein kinase A activityTASbiological_process
GO:0006006glucose metabolic processTASbiological_process
GO:0006629lipid metabolic processTASbiological_process
GO:0050796regulation of insulin secretionTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0007268synaptic transmissionTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0004691cAMP-dependent protein kinase activityIEAmolecular_function
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0007202activation of phospholipase C activityTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0006833water transportTASbiological_process
GO:0051447negative regulation of meiotic cell cycleIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function
GO:0071377cellular response to glucagon stimulusTASbiological_process


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