Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PINX1_HUMAN
Description:PIN2/TERF1 interacting, telomerase inhibitor 1 [Source:HGNC Symbol;Acc:30046]
Location:chr8 p23.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S163GDASPsTPEENPhosphoSitePlus
T171EENETtTTSAFPhosphoSitePlus
S117SLEEKsKISKNPhosphoSitePlus
T141SSRSKtDLDCIPhosphoSitePlus
T164DASPStPEENEPhosphoSitePlus; HPRD; phosphoELM
T170PEENEtTTTSAPhosphoSitePlus; HPRD; phosphoELM
S200VPVPGsDISETPhosphoSitePlus; HPRD
S161PEGDAsPSTPEPhosphoSitePlus; HPRD; phosphoELM
Y227KDVESyLQPKAPhosphoSitePlus
Y126KNRVHyMKFTKPhosphoSitePlus
S110KKEKKsFSLEEPhosphoSitePlus
T317ATLEEtLVKKKPhosphoSitePlus
S226GKDVEsYLQPKPhosphoSitePlus

Dephosphorylation site
PINX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000318966R211SCOSMICLung Cancer18948947
ENSP00000318966S161RCOSMICOvarian Cancer21720365
ENSP00000318966R209SDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
PINX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PINX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
M3K7_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
ACK1_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
ILK_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
PK3C3_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
PLK1_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
TESK2_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
KCC2A_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANPINX1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PINX1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0007004telomere maintenance via telomeraseIEAbiological_process
GO:0070034telomeric RNA bindingIDAmolecular_function
GO:0007080mitotic metaphase plate congressionIMPbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0000776kinetochoreIDAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005730nucleolusIEAcellular_component
GO:0051974negative regulation of telomerase activityTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005819spindleIDAcellular_component
GO:0010521telomerase inhibitor activityTASmolecular_function
GO:0051972regulation of telomerase activityTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0008285negative regulation of cell proliferationNASbiological_process
GO:0000781chromosome, telomeric regionIEAcellular_component
GO:0005730nucleolusIDAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0000228nuclear chromosomeIDAcellular_component
GO:0005739mitochondrionIDAcellular_component


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