| UniProt/SwissProt ID: | HSPB8_HUMAN |
| Description: | heat shock 22kDa protein 8 [Source:HGNC Symbol;Acc:30171] |
| Location: | chr12 q24.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S27 | RDSPLsSRLLD | PhosphoSitePlus; SysPTM | |
| T63 | SAWPGtLRSGM | PKC_group | phosphoELM; RegPhos; SysPTM |
| T87 | PAEGRtPPPFP | Erk1(MAPK3 | RegPhos |
| S57 | ALPRLsSAWPG | PhosphoSitePlus | |
| S14 | SCHYPsRLRRD | PKCa | RegPhos |
| T63 | SAWPGtLRSGM | PhosphoSitePlus; SysPTM | |
| S27 | RDSPLsSRLLD | MAPK3 | HPRD; phosphoELM; SysPTM |
| S104 | CVNVHsFKPEE | HSP20; YabP | PhosphoSitePlus |
| T87 | PAEGRtPPPFP | Erk1 | RegPhos |
| T63 | SAWPGtLRSGM | PKCa | RegPhos; SysPTM |
| S24 | DPFRDsPLSSR | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y118 | KTKDGyVEVSG | HPRD; phosphoELM | |
| S14 | SCHYPsRLRRD | PhosphoSitePlus | |
| S14 | SCHYPsRLRRD | PRKCA | HPRD |
| T87 | PAEGRtPPPFP | MAPK3 | HPRD; phosphoELM |
| Y118 | KTKDGyVEVSG | HSP20; YabP | PhosphoSitePlus |
| S27 | RDSPLsSRLLD | Erk1(MAPK3 | RegPhos; SysPTM |
| T63 | SAWPGtLRSGM | PRKCA | HPRD; SysPTM |
| S27 | RDSPLsSRLLD | Erk1 | RegPhos; SysPTM |
| T87 | PAEGRtPPPFP | PhosphoSitePlus | |
| S14 | SCHYPsRLRRD | PKC_group | phosphoELM; RegPhos |
| Dephosphorylation site |
| HSPB8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000281938 | G67S | Greenman2007 | Central Nervous System Neoplasms | 16618716, 17344846, 18428421 | ENSP00000281938 | G67S | Greenman2007, HPI | Neoplasms by Histologic Type | 16618716, 17344846, 18428421 |
| Differential expressed protein |
| HSPB8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HSPB8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | HSPB8_HUMAN | kinase -> substrate | HPRD |
| MK03_HUMAN | HSPB8_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| HSPB8_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005622 | intracellular | IDA | cellular_component |
| GO:0008219 | cell death | IEA | biological_process |
| GO:0008150 | biological_process | ND | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006950 | response to stress | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |