Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MCL1_HUMAN
Description:myeloid cell leukemia sequence 1 (BCL2-related) [Source:HGNC Symbol;Acc:6943]
Location:chr1 q21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T92PDVTAtPARLLPhosphoSitePlus
T163GSLPStPPPAEMAPK3phosphoELM
T163GSLPStPPPAEMAPK_groupRegPhos
T163GSLPStPPPAEErk2RegPhos
T163GSLPStPPPAEErk1(MAPK3RegPhos
S150ELVGEsGNNTSPhosphoSitePlus
T163GSLPStPPPAEGSK3BHPRD; RegPhos
T163GSLPStPPPAEGSK3AHPRD; RegPhos
S121ADAIMsPEEELPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T163GSLPStPPPAEPhosphoSitePlus; phosphoELM
S159TSTDGsLPSTPGSK3BHPRD; RegPhos
S159TSTDGsLPSTPGSK3AHPRD; RegPhos
Y347GAGLAyLHPRD
S159TSTDGsLPSTPPhosphoSitePlus; phosphoELM
T163GSLPStPPPAEErk2(MAPK1RegPhos
T163GSLPStPPPAEMAPK1HPRD; phosphoELM
Y347GAGLAyLIR__TMPhosphoSitePlus
T154ESGNNtSTDGSPhosphoSitePlus
S159TSTDGsLPSTPGSK-3_betaphosphoELM
S64GSAGAsPPSTLPhosphoSitePlus

Dephosphorylation site
MCL1_HUMAN do not have dephosphorylation site.

Mutation site
MCL1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000358022Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
MCL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANMCL1_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANMCL1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
GSK3B_HUMANMCL1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMCL1_HUMANkinase -> substrateRegPhos
GSK3A_HUMANMCL1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
MCL1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034097response to cytokine stimulusIDAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0005654nucleoplasmIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:2000811negative regulation of anoikisIMPbiological_process
GO:2001240negative regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0015266protein channel activityTASmolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:2001020regulation of response to DNA damage stimulusIMPbiological_process
GO:0005741mitochondrial outer membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0097136Bcl-2 family protein complexIDAcellular_component
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0051434BH3 domain bindingIEAmolecular_function
GO:0019725cellular homeostasisNASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001709cell fate determinationNASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0016020membraneIDAcellular_component
GO:0007275multicellular organismal developmentIEAbiological_process
GO:0006915apoptotic processIDAbiological_process
GO:0005759mitochondrial matrixIEAcellular_component
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0051434BH3 domain bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0043066negative regulation of apoptotic processTASbiological_process


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