| UniProt/SwissProt ID: | DUS1_HUMAN |
| Description: | dual specificity phosphatase 1 [Source:HGNC Symbol;Acc:3064] |
| Location: | chr5 q35.1 |
| Node attribute: | phosphotase; substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S296 | RRSIIsPNFSF | MAPK1 | HPRD; phosphoELM |
| S323 | SAEAGsPAMAV | Erk2(MAPK1 | RegPhos |
| S323 | SAEAGsPAMAV | MAPK1 | HPRD; phosphoELM |
| S359 | LSYLQsPITTS | Erk2 | RegPhos |
| S364 | SPITTsPSC | Erk1 | RegPhos |
| T141 | CSKQStPMGLS | PhosphoSitePlus | |
| S296 | RRSIIsPNFSF | Erk2(MAPK1 | RegPhos |
| S364 | SPITTsP | MAPK3 | HPRD; phosphoELM |
| S364 | SPITTsPSC__ | PhosphoSitePlus | |
| S323 | SAEAGsPAMAV | Erk2 | RegPhos |
| S296 | RRSIIsPNFSF | DSPc | PhosphoSitePlus |
| S146 | TPMGLsLPLST | PhosphoSitePlus | |
| S296 | RRSIIsPNFSF | Erk2 | RegPhos |
| S364 | SPITTsPSC | Erk1(MAPK3 | RegPhos |
| S140 | LCSKQsTPMGL | PhosphoSitePlus | |
| S359 | LSYLQsPITTS | PhosphoSitePlus; phosphoELM; RegPhos | |
| S359 | LSYLQsPITTS | MAPK1 | HPRD |
| S323 | SAEAGsPAMAV | PhosphoSitePlus | |
| Dephosphorylation site |
| DUS1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000239223 | E286Q | COSMIC | Breast Cancer | 20668451 | ENSP00000239223 | V206I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000239223 | P346S | COSMIC | Skin Cancer | 21984974 | ENSP00000239223 | M302V | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000239223 | T166N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000239223 | S163F | COSMIC | Breast Cancer | 20668451 |
| Differential expressed protein |
| DUS1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DUS1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | DUS1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| MK03_HUMAN | DUS1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| ZAGL2_HUMAN | DUS1_HUMAN | kinase -> substrate | RegPhos |
| DUS1_HUMAN | MK01_HUMAN | phosphatase -> substrate | HPRD |
| P53_HUMAN | DUS1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04010 | MAPK signaling pathway |
| hsa04726 | Serotonergic synapse |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051384 | response to glucocorticoid stimulus | IEA | biological_process |
| GO:0000188 | inactivation of MAPK activity | IBA | biological_process |
| GO:0008330 | protein tyrosine/threonine phosphatase activity | IEA | molecular_function |
| GO:0042542 | response to hydrogen peroxide | IEA | biological_process |
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | IBA | biological_process |
| GO:0006979 | response to oxidative stress | TAS | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0001706 | endoderm formation | IBA | biological_process |
| GO:0005654 | nucleoplasm | IBA | cellular_component |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase | TAS | molecular_function |
| GO:0032526 | response to retinoic acid | IEA | biological_process |
| GO:0033574 | response to testosterone stimulus | IEA | biological_process |
| GO:0032870 | cellular response to hormone stimulus | IEA | biological_process |
| GO:0042981 | regulation of apoptotic process | IBA | biological_process |
| GO:0007049 | cell cycle | IEA | biological_process |
| GO:0032355 | response to estradiol stimulus | IEA | biological_process |
| GO:0009416 | response to light stimulus | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051591 | response to cAMP | IEA | biological_process |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase a | IBA | molecular_function |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase acti | IEA | molecular_function |
| GO:0006470 | protein dephosphorylation | IEA | biological_process |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0051592 | response to calcium ion | IEA | biological_process |
| GO:0010033 | response to organic substance | IEA | biological_process |
| GO:0043065 | positive regulation of apoptotic process | IEA | biological_process |