Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DUS1_HUMAN
Description:dual specificity phosphatase 1 [Source:HGNC Symbol;Acc:3064]
Location:chr5 q35.1
Node attribute:phosphotase; substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S296RRSIIsPNFSFMAPK1HPRD; phosphoELM
S323SAEAGsPAMAVErk2(MAPK1RegPhos
S323SAEAGsPAMAVMAPK1HPRD; phosphoELM
S359LSYLQsPITTSErk2RegPhos
S364SPITTsPSCErk1RegPhos
T141CSKQStPMGLSPhosphoSitePlus
S296RRSIIsPNFSFErk2(MAPK1RegPhos
S364SPITTsPMAPK3HPRD; phosphoELM
S364SPITTsPSC__PhosphoSitePlus
S323SAEAGsPAMAVErk2RegPhos
S296RRSIIsPNFSFDSPcPhosphoSitePlus
S146TPMGLsLPLSTPhosphoSitePlus
S296RRSIIsPNFSFErk2RegPhos
S364SPITTsPSCErk1(MAPK3RegPhos
S140LCSKQsTPMGLPhosphoSitePlus
S359LSYLQsPITTSPhosphoSitePlus; phosphoELM; RegPhos
S359LSYLQsPITTSMAPK1HPRD
S323SAEAGsPAMAVPhosphoSitePlus

Dephosphorylation site
DUS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000239223E286QCOSMICBreast Cancer20668451
ENSP00000239223V206ICOSMICOvarian Cancer21720365
ENSP00000239223P346SCOSMICSkin Cancer21984974
ENSP00000239223M302VCOSMICHead and Neck Cancer21798893
ENSP00000239223T166NCOSMICOvarian Cancer21720365
ENSP00000239223S163FCOSMICBreast Cancer20668451

Differential expressed protein
DUS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DUS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANDUS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MK03_HUMANDUS1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
ZAGL2_HUMANDUS1_HUMANkinase -> substrateRegPhos
DUS1_HUMANMK01_HUMANphosphatase -> substrateHPRD
P53_HUMANDUS1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway
hsa04726Serotonergic synapse

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0000188inactivation of MAPK activityIBAbiological_process
GO:0008330protein tyrosine/threonine phosphatase activityIEAmolecular_function
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0006470protein dephosphorylationIBAbiological_process
GO:0006979response to oxidative stressTASbiological_process
GO:0005634nucleusIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0001706endoderm formationIBAbiological_process
GO:0005654nucleoplasmIBAcellular_component
GO:0004726non-membrane spanning protein tyrosine phosphataseTASmolecular_function
GO:0032526response to retinoic acidIEAbiological_process
GO:0033574response to testosterone stimulusIEAbiological_process
GO:0032870cellular response to hormone stimulusIEAbiological_process
GO:0042981regulation of apoptotic processIBAbiological_process
GO:0007049cell cycleIEAbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0009416response to light stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0051591response to cAMPIEAbiological_process
GO:0017017MAP kinase tyrosine/serine/threonine phosphatase aIBAmolecular_function
GO:0008138protein tyrosine/serine/threonine phosphatase actiIEAmolecular_function
GO:0006470protein dephosphorylationIEAbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0051592response to calcium ionIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process


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