Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LIFR_HUMAN
Description:leukemia inhibitory factor receptor alpha [Source:HGNC Symbol;Acc:6597]
Location:chr5 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1044LVSPDsPRSIDErk2(MAPK1RegPhos
S1077PKDEDsPKSNGPhosphoSitePlus; HPRD
S1044LVSPDsPRSIDMAPK_groupphosphoELM; RegPhos
Y759GFLRGyLFYFGfn3PhosphoSitePlus
Y492VENSSyLVALDfn3PhosphoSitePlus
S1044LVSPDsPRSIDMAPK1HPRD; phosphoELM
S1044LVSPDsPRSIDMAPK3phosphoELM
Y379SFSGKyVRLKRPhosphoSitePlus
S833VTKENsVGLIIDUF3827PhosphoSitePlus
Y762RGYLFyFGKGEfn3PhosphoSitePlus
Y974TAQVIyIDVQSPhosphoSitePlus
Y369PRATSyTLVESIL6Ra-bindPhosphoSitePlus
S927DTEIIsPVAERPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S534LTTEAsPSKGPHPRD
S490KGVENsSYLVAfn3PhosphoSitePlus
T531KQHLTtEASPSHPRD
S1044LVSPDsPRSIDPhosphoSitePlus
Y807QGKTSyHLVLRfn3PhosphoSitePlus
S491GVENSsYLVALfn3PhosphoSitePlus
S1044LVSPDsPRSIDErk2RegPhos
S1044LVSPDsPRSIDErk1(MAPK3RegPhos
Y807QGKTSyHLVLRHPRD
T530KKQHLtTEASPHPRD

Dephosphorylation site
LIFR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263409G264SCOSMICSkin Cancer21984974
ENSP00000263409F1068LHPIColorectal Cancer16959974
ENSP00000263409D578HBIOMARTBreast Cancer21930507, 21930502
ENSP00000398368R302HCOSMICOvarian Cancer21720365
ENSP00000263409F1068LSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000263409I135NCOSMICOvarian Cancer21720365
ENSP00000398368D578HBIOMARTBreast Cancer21930507, 21930502
ENSP00000398368F1068LCOSMICIntestines Cancer16959974
ENSP00000263409R302HCOSMICOvarian Cancer21720365
ENSP00000398368G264SCOSMICSkin Cancer21984974
ENSP00000398368F1068LHPIColorectal Cancer16959974
ENSP00000398368I135NCOSMICOvarian Cancer21720365

Differential expressed protein
LIFR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LIFR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANLIFR_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANLIFR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0005127ciliary neurotrophic factor receptor bindingIPImolecular_function
GO:0004897ciliary neurotrophic factor receptor activityIDAmolecular_function
GO:0008284positive regulation of cell proliferationIEAbiological_process
GO:0070120ciliary neurotrophic factor-mediated signaling patIDAbiological_process
GO:0034097response to cytokine stimulusIDAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0019838growth factor bindingIPImolecular_function
GO:0038165oncostatin-M-mediated signaling pathwayIDAbiological_process
GO:0004924oncostatin-M receptor activityIDAmolecular_function
GO:0005887integral to plasma membraneTAScellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0004923leukemia inhibitory factor receptor activityIDAmolecular_function
GO:0048861leukemia inhibitory factor signaling pathwayIDAbiological_process


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