| UniProt/SwissProt ID: | CNRG_HUMAN |
| Description: | phosphodiesterase 6G, cGMP-specific, rod, gamma [Source:HGNC Symbol;Acc:8789] |
| Location: | chr17 q25.3 |
| Node attribute: | effector; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T62 | MEGLGtDITVI | BARK1 | RegPhos |
| T62 | MEGLGtDITVI | GRK-2 | phosphoELM |
| T62 | MEGLGtDITVI | BARK1(GRK2 | RegPhos |
| T62 | MEGLGtDITVI | ADRBK1 | HPRD |
| T22 | AGGPVtPRKGP | MAPK3 | HPRD |
| T22 | AGGPVtPRKGP | PDE6_gamma | PhosphoSitePlus |
| T22 | AGGPVtPRKGP | Erk1 | RegPhos |
| Dephosphorylation site |
| CNRG_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CNRG_HUMAN do not have mutation site. |
| Differential expressed protein |
| CNRG_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CNRG_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAT1_HUMAN | CNRG_HUMAN | Gprotein -> effector | gpDB |
| ARBK1_HUMAN | CNRG_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| MK03_HUMAN | CNRG_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa00230 | Purine metabolism |
| hsa04744 | Phototransduction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity | IEA | molecular_function |
| GO:0007601 | visual perception | IEA | biological_process |
| GO:0000187 | activation of MAPK activity | IEA | biological_process |
| GO:0004857 | enzyme inhibitor activity | TAS | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0045742 | positive regulation of epidermal growth factor rec | IEA | biological_process |
| GO:0043086 | negative regulation of catalytic activity | TAS | biological_process |
| GO:0045745 | positive regulation of G-protein coupled receptor | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030553 | cGMP binding | IEA | molecular_function |