Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RPB1_HUMAN
Description:polymerase (RNA) II (DNA directed) polypeptide A, 220kDa [Source:HGNC Symbol;Acc:9187]
Location:chr17 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S269VVMQGsARNQDRNA_pol_Rpb1_1PhosphoSitePlus
S1882TSPTYsPTTPKHPRD; RegPhos
T1884PTYSPtTPKYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1616QSPSYsPTSPSphosphoELM
T1926PKYSPtSPTYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1619SYSPTsPSYSPMAPK1phosphoELM
T1915SPTSPtYSPTSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1889TTPKYsPTSPTRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y1383LERELyHVISFRNA_pol_Rpb1_5PhosphoSitePlus
S768YNNFKsMVVSGRNA_pol_Rpb1_4PhosphoSitePlus
Y618EDSGPyKHISPRNA_pol_Rpb1_3PhosphoSitePlus
S1889TTPKYsPTSPTHPRD
Y1895PTSPTySPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S777SGAKGsKINISRNA_pol_Rpb1_4PhosphoSitePlus
S1896TSPTYsPTSPVRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus; SysPTM
S1913KYSPTsPTYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus; SysPTM
S1850SYSPSsPEYTPRNA_pol_Rpb1_RPhosphoSitePlus
S1619SYSPTsPSYSPRNA_pol_Rpb1_RPhosphoSitePlus
T1929SPTSPtYSPTSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1836SYSPAsPKYTPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1616QSPSYsPTSPSCDK9phosphoELM; RegPhos
S1822TYTPSsPSYSPPhosphoSitePlus
S1857EYTPTsPKYSPHPRD
T1885TYSPTtPKYSPHPRD; phosphoELM
S1815RYTPQsPTYTPPhosphoSitePlus
S1896TSPTYsPTSPVHPRD; phosphoELM; RegPhos; SysPTM
T47KYPETtEGGRPRNA_pol_Rpb1_1PhosphoSitePlus
S1871KYSPTsPKYSPHPRD
S1619SYSPTsPSYSPErk2(MAPK1RegPhos
S1917TSPTYsPTSPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus; SysPTM
T1894SPTSPtYSPTSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1842PKYTPtSPSYSRNA_pol_Rpb1_RPhosphoSitePlus
Y1881PTSPTySPTTPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T736NTLRQtFENQVHPRD
T1898PTYSPtSPVYTRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1854SSPEYtPTSPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1941KGSTYsPTSPGRNA_pol_Rpb1_RPhosphoSitePlus
Y1902PTSPVyTPTSPHPRD
S1864KYSPTsPKYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y1853PSSPEyTPTSPHPRD; phosphoELM
T1884PTYSPtTPKYSHPRD
S1824TPSSPsYSPSSPhosphoSitePlus
S1857EYTPTsPKYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1919PTYSPtSPKYSphosphoELM; SysPTM
T1406LCDTMtCRGHLRNA_pol_Rpb1_5PhosphoSitePlus
S1962TSPAIsPDDSDHPRD
S1847TSPSYsPSSPERNA_pol_Rpb1_RPhosphoSitePlus
S1619SYSPTsPSYSPphosphoELM
S1868TSPKYsPTSPKHPRD
T1415HLMAItRHGVNRNA_pol_Rpb1_5PhosphoSitePlus
S1899TYSPTsPVYTPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1812SSPRYtPQSPTPhosphoSitePlus
Y1839PTSPKyTPTSPHPRD
T1863PKYSPtSPKYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1847TSPSYsPSSPEHPRD; phosphoELM
Y1874PTSPKySPTSPHPRD; phosphoELM; SysPTM
S1931TSPTYsPTSPKphosphoELM
S1951GYSPTsPTYSLPhosphoSitePlus
S1828PSYSPsSPSYSRNA_pol_Rpb1_RPhosphoSitePlus
Y1881PTSPTySPTTPHPRD; phosphoELM
T1905PVYTPtSPKYSHPRD; phosphoELM
Y1923PTSPKySPTSPphosphoELM; RegPhos
S1826SSPSYsPSSPSRNA_pol_Rpb1_RPhosphoSitePlus
S1910TSPKYsPTSPTRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1882TSPTYsPTTPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1878KYSPTsPTYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus; SysPTM
S530IVTPQsNRPVMRNA_pol_Rpb1_3PhosphoSitePlus
S777SGAKGsKINISRegPhos
S1920TYSPTsPKYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus; SysPTM
T1856PEYTPtSPKYSHPRD; phosphoELM
S1616QSPSYsPTSPSRNA_pol_Rpb1_RPhosphoSitePlus
S1849PSYSPsSPEYTHPRD; phosphoELM; SysPTM
S1966ISPDDsDEEN_PhosphoSitePlus
T1842PKYTPtSPSYSHPRD
T1912PKYSPtSPTYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1903TSPVYtPTSPKHPRD
Y1825PSSPSySPSSPPhosphoSitePlus
S1833SSPSYsPASPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1933PTYSPtSPKGSphosphoELM; RegPhos
T1840TSPKYtPTSPSHPRD
T1933PTYSPtSPKGSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y699ADSKTyQDIQNPhosphoSitePlus
T37KRMSVtEGGIKRNA_pol_Rpb1_1PhosphoSitePlus
T698IADSKtYQDIQPhosphoSitePlus
T1915SPTSPtYSPTSHPRD; phosphoELM
S1966ISPDDsDEHPRD
S1829SYSPSsPSYSPRNA_pol_Rpb1_RPhosphoSitePlus
Y1832PSSPSySPASPRNA_pol_Rpb1_RPhosphoSitePlus
S772KSMVVsGAKGSRegPhos
T1880SPTSPtYSPTTRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1618PSYSPtSPSYSRNA_pol_Rpb1_RPhosphoSitePlus
Y1860PTSPKySPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1878KYSPTsPTYSPHPRD; phosphoELM; RegPhos; SysPTM
T1891PKYSPtSPTYSHPRD; phosphoELM
S1875TSPKYsPTSPTRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T587PRPLWtGKQIFRNA_pol_Rpb1_3PhosphoSitePlus
S1899TYSPTsPVYTPHPRD
T608IRTHStHPDDERNA_pol_Rpb1_3PhosphoSitePlus
Y1909PTSPKySPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1863PKYSPtSPKYSHPRD
S1875TSPKYsPTSPTHPRD
S1920TYSPTsPKYSPphosphoELM; SysPTM
T732PTPGNtLRQTFRNA_pol_Rpb1_4PhosphoSitePlus
Y1846PTSPSySPSSPRNA_pol_Rpb1_RPhosphoSitePlus
Y763KSLSEyNNFKSRNA_pol_Rpb1_4PhosphoSitePlus
T1905PVYTPtSPKYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1913KYSPTsPTYSPHPRD; phosphoELM; SysPTM
T1870PKYSPtSPKYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1917TSPTYsPTSPKHPRD; phosphoELM; SysPTM
Y1853PSSPEyTPTSPRNA_pol_Rpb1_RPhosphoSitePlus
Y1888PTTPKySPTSPHPRD; phosphoELM
Y1867PTSPKySPTSPHPRD
Y1846PTSPSySPSSPHPRD
S1924TSPKYsPTSPTRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1868TSPKYsPTSPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1894SPTSPtYSPTSHPRD; phosphoELM
Y145RLTHVyDLCKGRNA_pol_Rpb1_1PhosphoSitePlus
S1836SYSPTsPKYTPHPRD; RegPhos
T1424VNRQDtGPLMKRNA_pol_Rpb1_5PhosphoSitePlus
S1864KYSPTsPKYSPHPRD
Y1109LNTFHyAGVSARNA_pol_Rpb1_5PhosphoSitePlus
S1927KYSPTsPTYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1906VYTPTsPKYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1892KYSPTsPTYSPHPRD; phosphoELM
S1850SYSPSsPEYTPHPRD; phosphoELM
T1877PKYSPtSPTYSHPRD
Y1930PTSPTySPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1885TYSPTtPKYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y1895PTSPTySPTSPHPRD
S1831SPSSPsYSPASRNA_pol_Rpb1_RPhosphoSitePlus
S1843KYTPTsPSYSPRNA_pol_Rpb1_RPhosphoSitePlus
T1898PTYSPtSPVYTHPRD; phosphoELM
Y145RLTHVyDLCKGHPRD; phosphoELM; RegPhos
Y1874PTSPKySPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus; SysPTM
S1821PTYTPsSPSYSPhosphoSitePlus
T1856PEYTPtSPKYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y1909PTSPKySPTSPHPRD; phosphoELM
T1919PTYSPtSPKYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus; SysPTM
S1906VYTPTsPKYSPHPRD
Y1902PTSPVyTPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1619SYSPTsPSYSPErk1(MAPK3RegPhos
S1861TSPKYsPTSPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y1930PTSPTySPTSPHPRD; RegPhos
Y1811PSSPRyTPQSPPhosphoSitePlus
T46IKYPEtTEGGRRNA_pol_Rpb1_1PhosphoSitePlus
S1931TSPTYsPTSPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1619SYSPTsPSYSPMAPK3phosphoELM
S1621SPTSPsYSPTSRNA_pol_Rpb1_RPhosphoSitePlus
T1819QSPTYtPSSPSPhosphoSitePlus
T1903TSPVYtPTSPKRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y1916PTSPTySPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1891PKYSPtSPTYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
Y1923PTSPKySPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1934TYSPTsPKGSTRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1845TPTSPsYSPSSRNA_pol_Rpb1_RPhosphoSitePlus
Y1839PASPKyTPTSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1861TSPKYsPTSPKHPRD
S1871KYSPTsPKYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S1934TYSPTsPKGSTHPRD; phosphoELM; RegPhos
S1927KYSPTsPTYSPHPRD; phosphoELM; RegPhos
S1892KYSPTsPTYSPRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
T1929SPTSPtYSPTSHPRD; phosphoELM; RegPhos
S1843KYTPTsPSYSPHPRD
T1877PKYSPtSPTYSRNA_pol_Rpb1_R; RNA_pol_RPhosphoSitePlus
S607CIRTHsTHPDDRNA_pol_Rpb1_3PhosphoSitePlus
S772KSMVVsGAKGSRNA_pol_Rpb1_4PhosphoSitePlus
S1849PSYSPsSPEYTRNA_pol_Rpb1_RPhosphoSitePlus; SysPTM

Dephosphorylation site
RPB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000314949V1009LCOSMICHead and Neck Cancer21798893
ENSP00000314949R960WBIOMARTBreast Cancer21930507, 21930502
ENSP00000314949Q289ECOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000314949Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.6315169874

Hyperphosphorylation site
RPB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRPB1_HUMANkinase -> substrateRegPhos
MK01_HUMANRPB1_HUMANkinase -> substrateRobert H Newman (2013)
CDK9_HUMANRPB1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK03_HUMANRPB1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00240Pyrimidine metabolism
hsa05169Epstein-Barr virus infection
hsa00230Purine metabolism
hsa03020RNA polymerase
hsa01100Metabolic pathways
hsa05168Herpes simplex infection
hsa05016Huntington's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:00063707-methylguanosine mRNA cappingTASbiological_process
GO:0006355regulation of transcription, DNA-dependentNASbiological_process
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0006289nucleotide-excision repairTASbiological_process
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0006366transcription from RNA polymerase II promoterNASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0003968RNA-directed RNA polymerase activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0003899DNA-directed RNA polymerase activityNASmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0005665DNA-directed RNA polymerase II, core complexIDAcellular_component
GO:0016032viral reproductionTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0000398mRNA splicing, via spliceosomeTASbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0008380RNA splicingTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIPImolecular_function