Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KSYK_HUMAN
Description:spleen tyrosine kinase [Source:HGNC Symbol;Acc:11491]
Location:chr9 q22.2
Node attribute:ubiquitination(target); substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y568WEAFSyGQKPYPkinase_TyrPhosphoSitePlus
T504NVLLVtQHYAKPkinase_TyrPhosphoSitePlus
Y348MDTEVyESPYASykRegPhos
Y525RADENyYKAQTautocatalysis RegPhos
Y507LVTQHyAKISDPkinase_TyrPhosphoSitePlus
Y348MDTEVyESPYAPhosphoSitePlus; phosphoELM; RegPhos
Y296SRIKSySFPKPPhosphoSitePlus; HPRD; phosphoELM
Y323VSFNPyEPELAPhosphoSitePlus; phosphoELM; RegPhos
Y546PECINyYKFSSRegPhos
Y352VYESPyADPEESYKHPRD; phosphoELM; RegPhos
Y203DNNGSyALCLLSH2PhosphoSitePlus
Y47RQSRNyLGGFASH2PhosphoSitePlus
Y131NLIREyVKQTWSYKHPRD; RegPhos
Y568WEAFSyGQKPYHPRD
S319QESTVsFNPYEPhosphoSitePlus; RegPhos
Y630RLRNYyYDVVNPhosphoSitePlus; RegPhos
Y526ADENYyKAQTHphosphoELM; RegPhos
S295ISRIKsYSFPKPhosphoSitePlus
S350TEVYEsPYADPPhosphoSitePlus
S316GNRQEsTVSFNPhosphoSitePlus; RegPhos
Y323VSFNPyEPELASYKHPRD; RegPhos
Y431QLDNPyIVRMIPkinase_TyrPhosphoSitePlus
S297RIKSYsFPKPGPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T530YYKAQtHGKWPPkinase_TyrPhosphoSitePlus
Y526ADENYyKAQTHSYKHPRD; phosphoELM; RegPhos
T73RELNGtYAIAGSH2PhosphoSitePlus
Y131NLIREyVKQTWLYNHPRD; RegPhos
T345ALPMDtEVYESPhosphoSitePlus
Y91ADLCHyHSQESSH2PhosphoSitePlus
S202RDNNGsYALCLSH2PhosphoSitePlus
Y244QLVEHySYKADSH2PhosphoSitePlus
Y526ADENYyKAQTHSykRegPhos
Y352VYESPyADPEESykRegPhos
Y631LRNYYyDVVN_PhosphoSitePlus
Y629LRLRNyYYDVVPhosphoSitePlus; RegPhos
Y74ELNGTyAIAGGSH2PhosphoSitePlus
S178ISREEsEQIVLSH2PhosphoSitePlus
Y28EEAEDyLVQGGSH2PhosphoSitePlus
Y323VSFNPyEPELALYNRegPhos
Y525RADENyYKAQTSYKHPRD; phosphoELM; RegPhos
Y546PECINyYKFSSPkinase_TyrPhosphoSitePlus
Y525RADENyYKAQTSykRegPhos
Y348MDTEVyESPYASYKHPRD; phosphoELM; RegPhos
Y526ADENYyKAQTHPkinase_TyrPhosphoSitePlus
Y352VYESPyADPEEPhosphoSitePlus; phosphoELM; RegPhos
Y525RADENyYKAQTPkinase_TyrPhosphoSitePlus

Dephosphorylation site
KSYK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364904*613YCOSMICRenal Cancer21248752
ENSP00000364904E600GBIOMARTBreast Cancer21930507, 21930502
ENSP00000364899*613WCOSMICOvarian Cancer21720365
ENSP00000364898D603HDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000364904*613WCOSMICOvarian Cancer21720365
ENSP00000364898E623GBIOMARTBreast Cancer21930507, 21930502
ENSP00000364899E600GBIOMARTBreast Cancer21930507, 21930502
ENSP00000364899*613YCOSMICRenal Cancer21248752
ENSP00000364907E623GBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
KSYK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y352TEVYESPyADPEEIRcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KSYK_HUMANI15RA_HUMANkinase -> substrateHPRD
KSYK_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCD72_HUMANkinase -> substrateNetPath
KSYK_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANSYUA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK14_HUMANKSYK_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANBCAP_HUMANkinase -> substrateKEGG; NetPath
KSYK_HUMAN3BP2_HUMANkinase -> substrateRegPhos; NetPath
KSYK_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCBL_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
KSYK_HUMANPLCG2_HUMANkinase -> substrateKEGG; NetPath
LYN_HUMANKSYK_HUMANkinase -> substrateRegPhos; NetPath
KSYK_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKAD2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANNFAM1_HUMANkinase -> substrateNetPath
KSYK_HUMANFAK2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKHDR2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANPRS6A_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCD79A_HUMANkinase -> substrateNetPath
KSYK_HUMANMK12_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANTYDP2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANRASA1_HUMANkinase -> substrateNetPath
KSYK_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANLAT_HUMANkinase -> substrateKEGG
KSYK_HUMANRXRA_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANMK03_HUMANkinase -> substrateNetPath
KSYK_HUMANIF4H_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANSHC1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
KSYK_HUMANETS1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANRUVB2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANVAV3_HUMANkinase -> substrateKEGG
KSYK_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANMLX_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCHSP1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANOTU7B_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANTYOBP_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANKSYK_HUMANkinase -> substrateNetPath
KSYK_HUMANLCP2_HUMANkinase -> substrateKEGG; Robert H Newman (2013)
FYN_HUMANKSYK_HUMANkinase -> substrateNetPath
KSYK_HUMANBLNK_HUMANkinase -> substrateKEGG; NetPath; Robert H Newman (2013)
KSYK_HUMANTBA4A_HUMANkinase -> substrateHPRD; RegPhos
KPCD1_HUMANKSYK_HUMANkinase -> substrateNetPath
KSYK_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
KSYK_HUMANFHL2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKC1G2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANLAX1_HUMANkinase -> substrateNetPath
KSYK_HUMANKPCA_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KSYK_HUMANPI3R5_HUMANkinase -> substrateKEGG
KSYK_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCIP4_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKSYK_HUMANkinase -> substrateRegPhos
KSYK_HUMANKSYK_HUMANkinase -> substrateRegPhos; NetPath
KSYK_HUMANLCK_HUMANkinase -> substrateHPRD; RegPhos
KSYK_HUMANDUS3_HUMANkinase -> substrateNetPath; Robert H Newman (2013)
KSYK_HUMANASCC1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKAP0_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANB3AT_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KSYK_HUMANGAB2_HUMANkinase -> substrateNetPath
KSYK_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANARAP1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANNP1L1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANPLCG1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
KSYK_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KSYK_HUMANCD79B_HUMANkinase -> substrateNetPath
KSYK_HUMANITB3_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANZYX_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANTIF1B_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANCSDE1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANBCL3_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANFCG2C_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANARI3A_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANMED28_HUMANkinase -> substrateRobert H Newman (2013)
JAK1_HUMANKSYK_HUMANkinase -> substrateNetPath
KSYK_HUMANM4K1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
KSYK_HUMANRBBP5_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANHCLS1_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
KSYK_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANKS6A1_HUMANkinase -> substrateNetPath
KSYK_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANNADAP_HUMANkinase -> substrateRobert H Newman (2013)
PTN6_HUMANKSYK_HUMANphosphatase -> substrateKEGG
CBLB_HUMANKSYK_HUMANubiquitinationNetPath
KSYK_HUMANGAB2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04662B cell receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa04380Osteoclast differentiation
hsa04064NF-kappa B signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa05152Tuberculosis
hsa04650Natural killer cell mediated cytotoxicity
hsa05203Viral carcinogenesis
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0090330regulation of platelet aggregationISSbiological_process
GO:0046777protein autophosphorylationIEAbiological_process
GO:0045780positive regulation of bone resorptionIEAbiological_process
GO:0050764regulation of phagocytosisIEAbiological_process
GO:0043313regulation of neutrophil degranulationISSbiological_process
GO:0048514blood vessel morphogenesisISSbiological_process
GO:0002250adaptive immune responseISSbiological_process
GO:0050715positive regulation of cytokine secretionIEAbiological_process
GO:0002554serotonin secretion by plateletIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0071226cellular response to molecule of fungal originIEAbiological_process
GO:0071226cellular response to molecule of fungal originISSbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0046638positive regulation of alpha-beta T cell differentIEAbiological_process
GO:0042742defense response to bacteriumISSbiological_process
GO:0050853B cell receptor signaling pathwayISSbiological_process
GO:0004672protein kinase activityNASmolecular_function
GO:0043313regulation of neutrophil degranulationIEAbiological_process
GO:0090237regulation of arachidonic acid secretionIEAbiological_process
GO:0002283neutrophil activation involved in immune responseISSbiological_process
GO:0002366leukocyte activation involved in immune responseIEAbiological_process
GO:0045087innate immune responseISSbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0001820serotonin secretionIEAbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0007257activation of JUN kinase activityIEAbiological_process
GO:0042742defense response to bacteriumIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0002554serotonin secretion by plateletISSbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0043366beta selectionIEAbiological_process
GO:0050850positive regulation of calcium-mediated signalingIEAbiological_process
GO:0002366leukocyte activation involved in immune responseISSbiological_process
GO:0045401positive regulation of interleukin-3 biosynthetic IEAbiological_process
GO:0033630positive regulation of cell adhesion mediated by iIEAbiological_process
GO:0045579positive regulation of B cell differentiationIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0000187activation of MAPK activityIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0045780positive regulation of bone resorptionISSbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045087innate immune responseIEAbiological_process
GO:0042101T cell receptor complexIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0032009early phagosomeIEAcellular_component
GO:0007159leukocyte cell-cell adhesionIDAbiological_process
GO:0019370leukotriene biosynthetic processIEAbiological_process
GO:0090330regulation of platelet aggregationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0001945lymph vessel developmentISSbiological_process
GO:0032928regulation of superoxide anion generationISSbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0006468protein phosphorylationISSbiological_process
GO:0033630positive regulation of cell adhesion mediated by iISSbiological_process
GO:0019815B cell receptor complexIEAcellular_component
GO:0007229integrin-mediated signaling pathwayISSbiological_process
GO:0001945lymph vessel developmentIEAbiological_process
GO:0030593neutrophil chemotaxisIDAbiological_process
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0032009early phagosomeISScellular_component
GO:0005829cytosolICcellular_component
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0008283cell proliferationTASbiological_process
GO:0002283neutrophil activation involved in immune responseIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0070372regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0050853B cell receptor signaling pathwayIEAbiological_process
GO:0043306positive regulation of mast cell degranulationIEAbiological_process
GO:0046641positive regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0010543regulation of platelet activationISSbiological_process
GO:0005178integrin bindingIPImolecular_function
GO:0002281macrophage activation involved in immune responseISSbiological_process
GO:0002281macrophage activation involved in immune responseIEAbiological_process
GO:0023014signal transduction by phosphorylationIEAbiological_process
GO:0090237regulation of arachidonic acid secretionISSbiological_process
GO:0007229integrin-mediated signaling pathwayIEAbiological_process
GO:0070372regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0045425positive regulation of granulocyte macrophage coloIEAbiological_process
GO:0045588positive regulation of gamma-delta T cell differenIEAbiological_process
GO:0010543regulation of platelet activationIEAbiological_process
GO:0050764regulation of phagocytosisISSbiological_process
GO:0004716receptor signaling protein tyrosine kinase activitIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0032928regulation of superoxide anion generationIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function