Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ETV6_HUMAN
Description:ets variant 6 [Source:HGNC Symbol;Acc:3495]
Location:chr12 p13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T161NCVQRtPRPSVPhosphoSitePlus
T18ERISYtPPESPPhosphoSitePlus; HPRD; phosphoELM
S131PRILFsPFFHPPhosphoSitePlus
S22YTPPEsPVPSYPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S257HPKPSsPRQESErk1(MAPK3RegPhos
T31SYASStPLHVPPhosphoSitePlus; HPRD; phosphoELM
Y314REDLAyMNHIMPhosphoSitePlus
S257HPKPSsPRQESp38a(MAPK14RegPhos
Y17QERISyTPPESPhosphoSitePlus; HPRD; phosphoELM
Y447LDEQIyQEDECPhosphoSitePlus
S213MIRRLsPAERAErk1(MAPK3RegPhos; SysPTM
S193TNHRPsPDPEQPhosphoSitePlus
S26ESPVPsYASSTPhosphoSitePlus
T142GNSIHtQPEVIPhosphoSitePlus
S182ELLHRsRSPITPhosphoSitePlus
Y402ALRHYyKLNIIEtsPhosphoSitePlus
S29VPSYAsSTPLHPhosphoSitePlus; HPRD; phosphoELM
S203QRPLRsPLDNMPhosphoSitePlus
Y60RLQPIyWSRDDSAM_PNTPhosphoSitePlus
S213MIRRLsPAERAPhosphoSitePlus; HPRD; SysPTM
S257HPKPSsPRQESPhosphoSitePlus
Y401RALRHyYKLNIEtsPhosphoSitePlus
S213MIRRLsPAERAMAPK3phosphoELM; SysPTM
T188RSPITtNHRPSPhosphoSitePlus
S271IQLMPsPIMHPPhosphoSitePlus
S184LHRSRsPITTNPhosphoSitePlus
S257HPKPSsPRQESMAPK3phosphoELM
Y27SPVPSyASSTPPhosphoSitePlus
S16KQERIsYTPPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T187SRSPItTNHRPPhosphoSitePlus
S30PSYASsTPLHVPhosphoSitePlus

Dephosphorylation site
ETV6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000379658D351HCOSMICHead and Neck Cancer21798893
ENSP00000379658N228SCOSMICSkin Cancer21984974
ENSP00000379658L306FCOSMICSkin Cancer21984974
ENSP00000379658R217TCOSMICHead and Neck Cancer21798897
ENSP00000379658R39*COSMICOvarian Cancer20826764
ENSP00000379658G375RCOSMICOvarian Cancer21720365
ENSP00000379658G375RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
ETV6_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ETV6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANETV6_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANETV6_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04320Dorso-ventral axis formation
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0019904protein domain specific bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function


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