| UniProt/SwissProt ID: | ETV6_HUMAN |
| Description: | ets variant 6 [Source:HGNC Symbol;Acc:3495] |
| Location: | chr12 p13.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T161 | NCVQRtPRPSV | PhosphoSitePlus | |
| T18 | ERISYtPPESP | PhosphoSitePlus; HPRD; phosphoELM | |
| S131 | PRILFsPFFHP | PhosphoSitePlus | |
| S22 | YTPPEsPVPSY | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S257 | HPKPSsPRQES | Erk1(MAPK3 | RegPhos |
| T31 | SYASStPLHVP | PhosphoSitePlus; HPRD; phosphoELM | |
| Y314 | REDLAyMNHIM | PhosphoSitePlus | |
| S257 | HPKPSsPRQES | p38a(MAPK14 | RegPhos |
| Y17 | QERISyTPPES | PhosphoSitePlus; HPRD; phosphoELM | |
| Y447 | LDEQIyQEDEC | PhosphoSitePlus | |
| S213 | MIRRLsPAERA | Erk1(MAPK3 | RegPhos; SysPTM |
| S193 | TNHRPsPDPEQ | PhosphoSitePlus | |
| S26 | ESPVPsYASST | PhosphoSitePlus | |
| T142 | GNSIHtQPEVI | PhosphoSitePlus | |
| S182 | ELLHRsRSPIT | PhosphoSitePlus | |
| Y402 | ALRHYyKLNII | Ets | PhosphoSitePlus |
| S29 | VPSYAsSTPLH | PhosphoSitePlus; HPRD; phosphoELM | |
| S203 | QRPLRsPLDNM | PhosphoSitePlus | |
| Y60 | RLQPIyWSRDD | SAM_PNT | PhosphoSitePlus |
| S213 | MIRRLsPAERA | PhosphoSitePlus; HPRD; SysPTM | |
| S257 | HPKPSsPRQES | PhosphoSitePlus | |
| Y401 | RALRHyYKLNI | Ets | PhosphoSitePlus |
| S213 | MIRRLsPAERA | MAPK3 | phosphoELM; SysPTM |
| T188 | RSPITtNHRPS | PhosphoSitePlus | |
| S271 | IQLMPsPIMHP | PhosphoSitePlus | |
| S184 | LHRSRsPITTN | PhosphoSitePlus | |
| S257 | HPKPSsPRQES | MAPK3 | phosphoELM |
| Y27 | SPVPSyASSTP | PhosphoSitePlus | |
| S16 | KQERIsYTPPE | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T187 | SRSPItTNHRP | PhosphoSitePlus | |
| S30 | PSYASsTPLHV | PhosphoSitePlus | |
| Dephosphorylation site |
| ETV6_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000379658 | D351H | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000379658 | N228S | COSMIC | Skin Cancer | 21984974 | ENSP00000379658 | L306F | COSMIC | Skin Cancer | 21984974 | ENSP00000379658 | R217T | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000379658 | R39* | COSMIC | Ovarian Cancer | 20826764 | ENSP00000379658 | G375R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000379658 | G375R | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| ETV6_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ETV6_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK03_HUMAN | ETV6_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | ETV6_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04320 | Dorso-ventral axis formation |
| hsa05202 | Transcriptional misregulation in cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0019904 | protein domain specific binding | IPI | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |