Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADA17_HUMAN
Description:ADAM metallopeptidase domain 17 [Source:HGNC Symbol;Acc:195]
Location:chr2 p25.1
Node attribute:cleavage(source); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T735FPAPQtPGRLQErk1(MAPK3RegPhos
T796SFEDLtDHPVTPhosphoSitePlus
Y379GKKNIyLNSGLPeptidase_M84PhosphoSitePlus
Y82RHFKLyLTSSTPep_M12B_propepPhosphoSitePlus
S382NIYLNsGLTSTHPRD; phosphoELM; RegPhos
T761HQRMDtIQEDPPhosphoSitePlus
S819QNRVDsKETHPRD; phosphoELM
T735FPAPQtPGRLQPhosphoSitePlus
S706QYESLsLFHPSPhosphoSitePlus
Y436GKYVMyPIAVSPeptidase_M84PhosphoSitePlus
T735FPAPQtPGRLQMAPK3phosphoELM
S770DPSTDsHMDEDPhosphoSitePlus
T735FPAPQtPGRLQMAPK_groupRegPhos
S791STAAKsFEDLTPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S819QNRVDsKETECPhosphoSitePlus; RegPhos
Y433DQGGKyVMYPIPeptidase_M84PhosphoSitePlus
Y379GKKNIyLNSGLHPRD; phosphoELM; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S791NSSTAAKsFEDLTDHHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309968Q341PBIOMARTBreast Cancer21930507, 21930502
ENSP00000309968P799LCOSMICSkin Cancer21984974
ENSP00000309968S40*COSMICRenal Cancer21248752
ENSP00000309968F235LCOSMICLung Cancer20668451

Differential expressed protein
ADA17_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADA17_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK03_HUMANADA17_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANADA17_HUMANkinase -> substrateRegPhos
ADA17_HUMANNOTC1_HUMANcleavageNetPath
ADA17_HUMANHBEGF_HUMANotherKEGG
ADA17_HUMANNOTC1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0030511positive regulation of transforming growth factor ISSbiological_process
GO:0008237metallopeptidase activityIEAmolecular_function
GO:0030183B cell differentiationIEAbiological_process
GO:0005178integrin bindingIPImolecular_function
GO:0007173epidermal growth factor receptor signaling pathwayIDAbiological_process
GO:0002467germinal center formationISSbiological_process
GO:0051272positive regulation of cellular component movementISSbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0032722positive regulation of chemokine productionIMPbiological_process
GO:0031659positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0002446neutrophil mediated immunityICbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0033025regulation of mast cell apoptotic processISSbiological_process
GO:0051088PMA-inducible membrane protein ectodomain proteolyIEAbiological_process
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0030511positive regulation of transforming growth factor IEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0048536spleen developmentIEAbiological_process
GO:0006509membrane protein ectodomain proteolysisIEAbiological_process
GO:0048870cell motilityIEAbiological_process
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0045741positive regulation of epidermal growth factor-actIMPbiological_process
GO:0033627cell adhesion mediated by integrinIDAbiological_process
GO:0030183B cell differentiationISSbiological_process
GO:0048870cell motilityISSbiological_process
GO:0033025regulation of mast cell apoptotic processIEAbiological_process
GO:0055099response to high density lipoprotein particle stimIDAbiological_process
GO:0051088PMA-inducible membrane protein ectodomain proteolyIDAbiological_process
GO:0010820positive regulation of T cell chemotaxisIMPbiological_process
GO:0005911cell-cell junctionIDAcellular_component
GO:0006509membrane protein ectodomain proteolysisIMPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0005925focal adhesionIDAcellular_component
GO:0030165PDZ domain bindingIPImolecular_function
GO:0033077T cell differentiation in thymusISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0002690positive regulation of leukocyte chemotaxisICbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007155cell adhesionIDAbiological_process
GO:0051272positive regulation of cellular component movementIEAbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0001934positive regulation of protein phosphorylationIMPbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0008237metallopeptidase activityIMPmolecular_function
GO:0001666response to hypoxiaIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0002467germinal center formationIEAbiological_process
GO:0004222metalloendopeptidase activityIMPmolecular_function
GO:0035625epidermal growth factor-activated receptor transacIMPbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0042493response to drugISSbiological_process
GO:0005138interleukin-6 receptor bindingIPImolecular_function
GO:0032587ruffle membraneIDAcellular_component
GO:0048536spleen developmentISSbiological_process
GO:0032717negative regulation of interleukin-8 productionIMPbiological_process
GO:0030307positive regulation of cell growthIMPbiological_process
GO:0032496response to lipopolysaccharideIDAbiological_process
GO:0035313wound healing, spreading of epidermal cellsIEPbiological_process
GO:0016324apical plasma membraneIDAcellular_component
GO:0015629actin cytoskeletonIDAcellular_component