Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LEUK_HUMAN
Description:sialophorin [Source:HGNC Symbol;Acc:11249]
Location:chr16 p11.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S156VTTAAsSLETSPhosphoSitePlus
S368SGSGPsLKGEEPhosphoSitePlus
T341SSRRPtLTTFFPhosphoSitePlus; HPRD
S363MEELKsGSGPSPhosphoSitePlus
S336PDGEGsSRRPTPhosphoSitePlus
S355KSRQGsLAMEEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
T344RPTLTtFFGRRPhosphoSitePlus
T153GAPVTtAASSLPhosphoSitePlus
S351FGRRKsRQGSLPKCa(PKC alphaRegPhos
S291GALVLsRGGKRPhosphoSitePlus; HPRD
T343RRPTLtTFFGRPhosphoSitePlus
S351FGRRKsRQGSLPKC_alphaphosphoELM
S351FGRRKsRQGSLPhosphoSitePlus; HPRD
S211TMTTGsLEPSSPhosphoSitePlus
S337DGEGSsRRPTLPhosphoSitePlus
S365ELKSGsGPSLKPhosphoSitePlus
T236MMSPTtSTNASPhosphoSitePlus
S328GGDKGsGFPDGPhosphoSitePlus

Dephosphorylation site
LEUK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353238P116TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000378787P116TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000353238P389HCOSMICOvarian Cancer21720365
ENSP00000353238P116TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000455266P116TTCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000353238LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineDown17449014

Hyperphosphorylation site
LEUK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANLEUK_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANLEUK_HUMANkinase -> substrateRegPhos
SP1_HUMANLEUK_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)
hsa05169Epstein-Barr virus infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050776regulation of immune responseIEAbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0007162negative regulation of cell adhesionIEAbiological_process
GO:0001562response to protozoanIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0031295T cell costimulationIEAbiological_process
GO:0051635bacterial cell surface bindingIEAmolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0042742defense response to bacteriumIEAbiological_process
GO:0004888transmembrane signaling receptor activityTASmolecular_function
GO:0001931uropodIEAcellular_component
GO:0005887integral to plasma membraneIEAcellular_component
GO:0042535positive regulation of tumor necrosis factor biosyIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0050688regulation of defense response to virusIEAbiological_process
GO:0006955immune responseTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007163establishment or maintenance of cell polarityTASbiological_process
GO:0042130negative regulation of T cell proliferationIEAbiological_process
GO:0006968cellular defense responseTASbiological_process
GO:0007165signal transductionTASbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0001808negative regulation of type IV hypersensitivityIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0050868negative regulation of T cell activationIEAbiological_process


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