Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DYR_HUMAN
Description:dihydrofolate reductase [Source:HGNC Symbol;Acc:2861]
Location:chr5 q14.1
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y183YKFEVyEKND_DHFR_1PhosphoSitePlus
Y157IDLEKyKLLPEDHFR_1PhosphoSitePlus

Dephosphorylation site
DYR_HUMAN do not have dephosphorylation site.

Mutation site
DYR_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000396308acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown17655343
ENSP00000396308acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343

Hyperphosphorylation site
DYR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TBP_HUMANDYR_HUMANTF -> target geneTRANSFAC
SP1_HUMANDYR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
DYR_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006766vitamin metabolic processTASbiological_process
GO:0046654tetrahydrofolate biosynthetic processIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0008144drug bindingIDAmolecular_function
GO:0055114oxidation-reduction processIEAbiological_process
GO:0005575cellular_componentNDcellular_component
GO:0003729mRNA bindingIDAmolecular_function
GO:0006767water-soluble vitamin metabolic processTASbiological_process
GO:0050661NADP bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0046655folic acid metabolic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0050999regulation of nitric-oxide synthase activityTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0006545glycine biosynthetic processIEAbiological_process
GO:0046653tetrahydrofolate metabolic processIDAbiological_process
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0004146dihydrofolate reductase activityIEAmolecular_function
GO:0031427response to methotrexateIEAbiological_process
GO:0006730one-carbon metabolic processIEAbiological_process
GO:0009165nucleotide biosynthetic processIEAbiological_process
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0046209nitric oxide metabolic processTASbiological_process


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