Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MDR1_HUMAN
Description:ATP-binding cassette, sub-family B (MDR/TAP), member 1 [Source:HGNC Symbol;Acc:40]
Location:chr7 q21.12
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T422VQSGQtVALVGABC_tranPhosphoSitePlus
T684DRKLStKEALDPhosphoSitePlus
Y1087LLERFyDPLAGABC_tranPhosphoSitePlus
S667LIRKRsTRRSVPhosphoSitePlus; HPRD
S667LIRKRsTRRSVPKA_groupphosphoELM
T33KEKKPtVSVFSHPRD
S661NDSRSsLIRKRPKC_groupphosphoELM
S644NAADEsKSEIDHPRD; phosphoELM
S660SNDSRsSLIRKHPRD; phosphoELM
T1023IDSYStEGLMPPhosphoSitePlus
S35KKPTVsVFSMFHPRD
S683QDRKLsTKEALPhosphoSitePlus; HPRD
S696SIPPVsFWRIMPhosphoSitePlus
T1030GLMPNtLEGNVPhosphoSitePlus
S667LIRKRsTRRSVPKC_groupphosphoELM
T522PHKFDtLVGERABC_tranPhosphoSitePlus
S661NDSRSsLIRKRPhosphoSitePlus; HPRD; phosphoELM
T1015MIIEKtPLIDSPhosphoSitePlus
S683QDRKLsTKEALPKA_groupphosphoELM
S23KLNNKsEKDKKPhosphoSitePlus; HPRD
S671RSTRRsVRGSQPKC_groupphosphoELM
T496GRENVtMDEIEABC_tranPhosphoSitePlus
S658MSSNDsRSSLIHPRD; phosphoELM
T263LAAIRtVIAFGABC_membranePhosphoSitePlus
S671RSTRRsVRGSQPhosphoSitePlus; HPRD

Dephosphorylation site
MDR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265724K887NSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000265724K887NHPIColorectal Cancer16959974
ENSP00000265724R1085WCOSMICOvarian Cancer21720365
ENSP00000265724R749*COSMICOvarian Cancer21720365
ENSP00000265724G722VCOSMICOvarian Cancer21720365
ENSP00000265724K18TCOSMICHead and Neck Cancer21798897
ENSP00000265724A250TCOSMICCentral Nervous System Neoplasms18772396
ENSP00000265724R538SBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000265724Gastric CancerTreatment (none vs. drug-resistant)cell lineUp4.420625496

Hyperphosphorylation site
MDR1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NFYB_HUMANMDR1_HUMANTF -> target geneTRANSFAC
NFYA_HUMANMDR1_HUMANTF -> target geneTRANSFAC
EGR2_HUMANMDR1_HUMANTF -> target geneTRANSFAC
SP1_HUMANMDR1_HUMANTF -> target geneTRANSFAC
CEBPB_HUMANMDR1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MDR1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005886plasma membraneTAScellular_component
GO:0016020membraneTAScellular_component
GO:0016887ATPase activityIEAmolecular_function
GO:0009986cell surfaceIDAcellular_component
GO:0042626ATPase activity, coupled to transmembrane movementIBAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0055085transmembrane transportIBAbiological_process
GO:0000139Golgi membraneIBAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0000086G2/M transition of mitotic cell cycleIDAbiological_process
GO:0046581intercellular canaliculusIBAcellular_component
GO:0006855drug transmembrane transportTASbiological_process
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0006810transportTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005215transporter activityTASmolecular_function
GO:0008559xenobiotic-transporting ATPase activityIEAmolecular_function
GO:0016324apical plasma membraneIBAcellular_component
GO:0042493response to drugTASbiological_process
GO:0072089stem cell proliferationIMPbiological_process
GO:0016021integral to membraneIBAcellular_component


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