Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOAT1_HUMAN
Description:sterol O-acyltransferase 1 [Source:HGNC Symbol;Acc:11177]
Location:chr1 q25.2
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S16NRLSKsRENPEPhosphoSitePlus
S8GEEKMsLRNRLPhosphoSitePlus
S14LRNRLsKSRENPhosphoSitePlus
S71MKEVGsHFDDFPhosphoSitePlus

Dephosphorylation site
SOAT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356591R27KCOSMICMelanoma21499247

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000356591Renal CancerNormal vs. CancertissueDown19164279

Hyperphosphorylation site
SOAT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANSOAT1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
SOAT1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0010742macrophage derived foam cell differentiationIMPbiological_process
GO:0016020membraneIDAcellular_component
GO:0004772sterol O-acyltransferase activityIEAmolecular_function
GO:0015485cholesterol bindingIDAmolecular_function
GO:0034736cholesterol O-acyltransferase activityIDAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0005789endoplasmic reticulum membraneIDAcellular_component
GO:0008203cholesterol metabolic processIEAbiological_process
GO:0034435cholesterol esterificationIDAbiological_process
GO:0042986positive regulation of amyloid precursor protein bIMPbiological_process
GO:0034379very-low-density lipoprotein particle assemblyIMPbiological_process
GO:0000062fatty-acyl-CoA bindingIDAmolecular_function
GO:0042632cholesterol homeostasisTASbiological_process
GO:0033344cholesterol effluxIMPbiological_process
GO:0010878cholesterol storageIMPbiological_process


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