| UniProt/SwissProt ID: | K6PF_HUMAN |
| Description: | phosphofructokinase, muscle [Source:HGNC Symbol;Acc:8877] |
| Location: | chr12 q13.11 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T82 | LQLGGtVIGSA | HPRD | |
| S377 | KLRGRsFMNNW | HPRD | |
| S667 | MQQGGsPTPFD | HPRD | |
| T2 | EEHH | HPRD; phosphoELM; SysPTM | |
| S775 | ITRKRsGEA | HPRD | |
| S72 | EATWEsVSMML | HPRD | |
| Dephosphorylation site |
| K6PF_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000449426 | H437L | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000352842 | R345C | COSMIC | Ovarian Cancer | 20826764 | ENSP00000449426 | R345C | COSMIC | Ovarian Cancer | 20826764 | ENSP00000352842 | T548A | COSMIC | Renal Cancer | ENSP00000449426 | T548A | COSMIC | Renal Cancer | ENSP00000309438 | R345C | COSMIC | Ovarian Cancer | 20826764 | ENSP00000309438 | H437L | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000309438 | T548A | COSMIC | Renal Cancer | ENSP00000352842 | H437L | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000352842 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| K6PF_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | K6PF_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| K6PF_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051259 | protein oligomerization | IDA | biological_process |
| GO:0046716 | muscle cell homeostasis | IMP | biological_process |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0016324 | apical plasma membrane | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0032024 | positive regulation of insulin secretion | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0003872 | 6-phosphofructokinase activity | IEA | molecular_function |
| GO:0005524 | ATP binding | IDA | molecular_function |
| GO:0070061 | fructose binding | IDA | molecular_function |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0042593 | glucose homeostasis | IEA | biological_process |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0006006 | glucose metabolic process | TAS | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005945 | 6-phosphofructokinase complex | IEA | cellular_component |
| GO:0019900 | kinase binding | IPI | molecular_function |
| GO:0006002 | fructose 6-phosphate metabolic process | IEA | biological_process |
| GO:0006096 | glycolysis | IEA | biological_process |