Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:K6PF_HUMAN
Description:phosphofructokinase, muscle [Source:HGNC Symbol;Acc:8877]
Location:chr12 q13.11
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T82LQLGGtVIGSAHPRD
S377KLRGRsFMNNWHPRD
S667MQQGGsPTPFDHPRD
T2EEHHHPRD; phosphoELM; SysPTM
S775ITRKRsGEAHPRD
S72EATWEsVSMMLHPRD

Dephosphorylation site
K6PF_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000449426H437LCOSMICHead and Neck Cancer21798897
ENSP00000352842R345CCOSMICOvarian Cancer20826764
ENSP00000449426R345CCOSMICOvarian Cancer20826764
ENSP00000352842T548ACOSMICRenal Cancer
ENSP00000449426T548ACOSMICRenal Cancer
ENSP00000309438R345CCOSMICOvarian Cancer20826764
ENSP00000309438H437LCOSMICHead and Neck Cancer21798897
ENSP00000309438T548ACOSMICRenal Cancer
ENSP00000352842H437LCOSMICHead and Neck Cancer21798897

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000352842Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
K6PF_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANK6PF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
K6PF_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051259protein oligomerizationIDAbiological_process
GO:0046716muscle cell homeostasisIMPbiological_process
GO:0005975carbohydrate metabolic processTASbiological_process
GO:0016324apical plasma membraneIDAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0044281small molecule metabolic processTASbiological_process
GO:00038726-phosphofructokinase activityIEAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0070061fructose bindingIDAmolecular_function
GO:0042802identical protein bindingIPImolecular_function
GO:0042593glucose homeostasisIEAbiological_process
GO:0008022protein C-terminus bindingIPImolecular_function
GO:0006006glucose metabolic processTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:00059456-phosphofructokinase complexIEAcellular_component
GO:0019900kinase bindingIPImolecular_function
GO:0006002fructose 6-phosphate metabolic processIEAbiological_process
GO:0006096glycolysisIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23