Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:INSR_HUMAN
Description:insulin receptor [Source:HGNC Symbol;Acc:6091]
Location:chr19 p13.2
Node attribute:PPI(target); substrate; kinase; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y992PLGPLyASSNPINSRHPRD; phosphoELM; RegPhos
Y999SSNPEyLSASDINSRHPRD; phosphoELM; RegPhos
S1064VNESAsLRERIPRKCAHPRD
Y1011FPCSVyVPDEWPhosphoSitePlus
Y1190YETDYyRKGGKInsRRegPhos
S1064VNESAsLRERIPKC_alphaphosphoELM
Y999SSNPEyLSASDautocatalysisRegPhos
S1221SSDMWsFGVVLPkinase_TyrPhosphoSitePlus
T1375NGRILtLPRSNPKCa(PKC alphaRegPhos
Y1361EEHIPyTHMNGPhosphoSitePlus
Y401KIRRSyALVSLRecep_L_domainPhosphoSitePlus
T1187RDIYEtDYYRKPkinase_TyrPhosphoSitePlus
Y987SSNPEyLSASDHPRD
S407ALVSLsFFRKLRecep_L_domainPhosphoSitePlus
Y992PLGPLyASSNPautocatalysis RegPhos
Y999SSNPEyLSASDPhosphoSitePlus; phosphoELM
Y1185MTRDIyETDYYINSRHPRD; phosphoELM; RegPhos
Y1178YETDYyRKGGKHPRD
S1314NKAPEsEELEMPhosphoSitePlus; HPRD; RegPhos
T731SSFRKtFEDYLPhosphoSitePlus
S1216GVFTTsSDMWSPkinase_TyrPhosphoSitePlus
S464PKLCLsEIHKMRecep_L_domainPhosphoSitePlus
T361ELRGCtVINGSRecep_L_domainPhosphoSitePlus
T1362EHIPYtHMNGGPRKCAHPRD
Y1355GFKRSyEEHIPPhosphoSitePlus
S1064VNESAsLRERIPKCa(PKC alphaRegPhos
Y1355GFKRSyEEHIPINSRHPRD; phosphoELM; RegPhos
S400LKIRRsYALVSRecep_L_domainPhosphoSitePlus
Y992PLGPLyASSNPPhosphoSitePlus
S1064VNESAsLRERIPKCaRegPhos
T1362EHIPYtHMNGGPKCaRegPhos
Y992PLGPLyASSNPInsRRegPhos
Y1189IYETDyYRKGGInsRRegPhos
S1062KTVNEsASLREPKCa(PKC alphaRegPhos
S1062KTVNEsASLREPRKCAHPRD
T1375NGRILtLPRSNPKC_groupphosphoELM; RegPhos
Y1173MTRDIyETDYYHPRD
Y1361EEHIPyTHMNGInsRRegPhos
S1348RDGGSsLGFKRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1375NGRILtLPRSNPKC_alphaphosphoELM
Y1361EEHIPyTHMNGautocatalysisRegPhos
S1062KTVNEsASLREPkinase_TyrPhosphoSitePlus
S1062KTVNEsASLREPKC_alphaphosphoELM
Y1177IYETDyYRKGGHPRD
T1375NGRILtLPRSNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S407ALVSLsFFRKLHPRD; phosphoELM
Y1189IYETDyYRKGGphosphoELM
Y1185MTRDIyETDYYphosphoELM
Y1185MTRDIyETDYYPkinase_TyrPhosphoSitePlus
Y401KIRRSyALVSLHPRD; phosphoELM
S1354LGFKRsYEEHIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T1362EHIPYtHMNGGPhosphoSitePlus
Y1349EEHIPyTHMNGHPRD
Y818RHFTGyRIELQfn3PhosphoSitePlus
Y1149ADGMAyLNAKKPkinase_Tyr; B2PhosphoSitePlus
Y1190YETDYyRKGGKINSRHPRD; phosphoELM; RegPhos
S1062KTVNEsASLREPKCaRegPhos
S1033ELGQGsFGMVYPkinase_TyrPhosphoSitePlus
Y1189IYETDyYRKGGINSRHPRD; phosphoELM; RegPhos
S1064VNESAsLRERIPkinase_TyrPhosphoSitePlus
S1342LGFKRsYEEHIHPRD
Y1190YETDYyRKGGKphosphoELM
Y1355GFKRSyEEHIPautocatalysisRegPhos
Y1190YETDYyRKGGKPkinase_TyrPhosphoSitePlus
Y1355GFKRSyEEHIPInsRRegPhos
Y1185MTRDIyETDYYInsRRegPhos
Y1011FPCSVyVPDEWInsRRegPhos
Y1190YETDYyRKGGKautocatalysisRegPhos
S1332VPLDRsSHCQRPhosphoSitePlus; phosphoELM; RegPhos
Y1343GFKRSyEEHIPHPRD
Y1189IYETDyYRKGGautocatalysisRegPhos
Y1011FPCSVyVPDEWINSRphosphoELM
Y1189IYETDyYRKGGPkinase_TyrPhosphoSitePlus
S1333PLDRSsHCQREPhosphoSitePlus; phosphoELM; RegPhos
Y1361EEHIPyTHMNGINSRHPRD; phosphoELM; RegPhos
Y999SSNPEyLSASDInsRRegPhos
S1217VFTTSsDMWSFPkinase_TyrPhosphoSitePlus
Y1185MTRDIyETDYYautocatalysisRegPhos
S400LKIRRsYALVSHPRD; phosphoELM
Y1011FPCSVyVPDEWautocatalysis RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1185FGMTRDIyETDYYRKPTPN1HPRD
Y1177RDIYETDyYRKGGKGPTPN1HPRD
Y1190DIYETDYyRKGGKGLPTPN1HPRD
Y1190DIYETDYyRKGGKGLPTPN2HPRD
Y1189RDIYETDyYRKGGKGPTPREHPRD
Y999YASSNPEyLSASDVFPTPREHPRD
Y1185FGMTRDIyETDYYRKPTPRCHPRD
Y1185FGMTRDIyETDYYRKPTPREHPRD
Y1173FGMTRDIyETDYYRKPTPN1HPRD
Y1178DIYETDYyRKGGKGLPTPN1HPRD
Y999YASSNPEyLSASDVFHPRD
Y1190DIYETDYyRKGGKGLPTPREHPRD
Y999YASSNPEyLSASDVFPTPN2HPRD
Y1189RDIYETDyYRKGGKGPTPN1HPRD
Y1189RDIYETDyYRKGGKGPTPN2HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000303830R833QCOSMICProstate Cancer20668451
ENSP00000303830S1094YCOSMICOvarian Cancer21720365
ENSP00000303830R1378QCOSMICBreast Cancer20668451
ENSP00000303830C228RGreenman2007, HPIGastric Cancer17344846, 18428421
ENSP00000303830S161FCOSMICMelanoma21499247
ENSP00000303830G1346EDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000303830G386CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000303830G910VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000303830K584NCOSMICLung Cancer20668451
ENSP00000303830K1047MCOSMICOvarian Cancer21720365
ENSP00000303830D1293YCOSMICOvarian Cancer21720365
ENSP00000303830G919ECOSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000303830Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
INSR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
IGF2_HUMANINSR_HUMANligand -> receptorHPMR
INS_HUMANINSR_HUMANligand -> receptorHPMR
NAMPT_HUMANINSR_HUMANligand -> receptorHPMR
INSR_HUMANCBLC_HUMANkinase -> substrateKEGG
INSR_HUMANADRB2_HUMANkinase -> substrateRegPhos
INSR_HUMANPTN6_HUMANkinase -> substrateHPRD; RegPhos
INSR_HUMANIRS1_HUMANkinase -> substrateRegPhos
INSR_HUMANSHC1_HUMANkinase -> substrateHPRD; RegPhos
INSR_HUMANINSR_HUMANkinase -> substrateRegPhos
INSR_HUMANFABP4_HUMANkinase -> substrateHPRD; RegPhos
KPCA_HUMANINSR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
INSR_HUMANSHC2_HUMANkinase -> substrateKEGG
INSR_HUMANCBL_HUMANkinase -> substrateHPRD; RegPhos
INSR_HUMANPTN1_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANINSR_HUMANkinase -> substrateRegPhos
INSR_HUMANP85A_HUMANkinase -> substrateRegPhos
INSR_HUMANCALM_HUMANkinase -> substrateHPRD; RegPhos
INSR_HUMANFAK1_HUMANkinase -> substrateRegPhos
INSR_HUMANSH2B2_HUMANkinase -> substrateKEGG
INSR_HUMANGAB1_HUMANkinase -> substrateRegPhos
INSR_HUMANIRS2_HUMANkinase -> substrateRegPhos
INSR_HUMANNAR4_HUMANkinase -> substrateRegPhos
PTN1_HUMANINSR_HUMANphosphatase -> substrateHPRD; KEGG
PTPRF_HUMANINSR_HUMANphosphatase -> substrateKEGG
SOCS6_HUMANINSR_HUMANphosphatase -> substrateKEGG
PTPRC_HUMANINSR_HUMANphosphatase -> substrateHPRD
PTN2_HUMANINSR_HUMANphosphatase -> substrateHPRD
PTPRE_HUMANINSR_HUMANphosphatase -> substrateHPRD
INS_HUMANINSR_HUMANotherKEGG
SP1_HUMANINSR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04520Adherens junction
hsa04930Type II diabetes mellitus
hsa04960Aldosterone-regulated sodium reabsorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051425PTB domain bindingIPImolecular_function
GO:0045740positive regulation of DNA replicationIMPbiological_process
GO:0045725positive regulation of glycogen biosynthetic proceIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0042593glucose homeostasisIMPbiological_process
GO:0005886plasma membraneICcellular_component
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0008286insulin receptor signaling pathwayIDAbiological_process
GO:0004713protein tyrosine kinase activityIMPmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0005901caveolaIDAcellular_component
GO:0032869cellular response to insulin stimulusIDAbiological_process
GO:0060267positive regulation of respiratory burstIDAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0005009insulin-activated receptor activityIDAmolecular_function
GO:0048639positive regulation of developmental growthIMPbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0000187activation of MAPK activityIMPbiological_process
GO:0045995regulation of embryonic developmentIMPbiological_process
GO:0043548phosphatidylinositol 3-kinase bindingIPImolecular_function
GO:0016020membraneIDAcellular_component
GO:0004716receptor signaling protein tyrosine kinase activitIDAmolecular_function
GO:0045821positive regulation of glycolysisIMPbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actIEAmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045840positive regulation of mitosisIMPbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0030238male sex determinationIEAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0005159insulin-like growth factor receptor bindingIDAmolecular_function
GO:0005975carbohydrate metabolic processIEAbiological_process
GO:0031995insulin-like growth factor II bindingIPImolecular_function
GO:0043560insulin receptor substrate bindingIPImolecular_function
GO:0009887organ morphogenesisIEAbiological_process
GO:0008286insulin receptor signaling pathwayIEAbiological_process
GO:0042169SH2 domain bindingIPImolecular_function
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0005899insulin receptor complexIMPcellular_component
GO:0032147activation of protein kinase activityIMPbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0016020membraneIEAcellular_component
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0010008endosome membraneTAScellular_component
GO:0005887integral to plasma membraneIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0023014signal transduction by phosphorylationIDAbiological_process
GO:0045725positive regulation of glycogen biosynthetic proceIDAbiological_process
GO:0019087transformation of host cell by virusIMPbiological_process
GO:0031994insulin-like growth factor I bindingIPImolecular_function
GO:0005525GTP bindingIDAmolecular_function
GO:0005524ATP bindingIDAmolecular_function
GO:0045429positive regulation of nitric oxide biosynthetic pIMPbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0051290protein heterotetramerizationIDAbiological_process
GO:0031017exocrine pancreas developmentIEAbiological_process
GO:0005901caveolaIEAcellular_component
GO:0046326positive regulation of glucose importNASbiological_process
GO:0043559insulin bindingIDAmolecular_function
GO:0008284positive regulation of cell proliferationICbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0003007heart morphogenesisIMPbiological_process