Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:AP2C_HUMAN
Description:transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) [Source:HGNC Symbol;Acc:11744]
Location:chr20 q13.31
Node attribute:gene; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S252VQRRLsPPECLphosphoELM
S238LLSSTsKYKVTTF_AP-2PhosphoSitePlus
S434NPGDQsPADSNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S252VQRRLsPPECLTF_AP-2PhosphoSitePlus

Dephosphorylation site
AP2C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000201031M351ICOSMICCentral Nervous System Neoplasms18772890
ENSP00000201031M351ITCGANeoplasms by Histologic Type21720365, 18772890

Differential expressed protein
AP2C_HUMAN is not differential expressed protein.

Hyperphosphorylation site
AP2C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP3_HUMANAP2C_HUMANTF -> target geneTRANSFAC
SP1_HUMANAP2C_HUMANTF -> target geneTRANSFAC
AP2C_HUMANSODM_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
AP2C_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0045682regulation of epidermis developmentIEAbiological_process
GO:0060750epithelial cell proliferation involved in mammary IEAbiological_process
GO:0001942hair follicle developmentIEAbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0019827stem cell maintenanceIEAbiological_process
GO:0030718germ-line stem cell maintenanceIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0000977RNA polymerase II regulatory region sequence-speciIEAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0003334keratinocyte developmentIEAbiological_process
GO:0021877forebrain neuron fate commitmentIEAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0043588skin developmentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0008584male gonad developmentIEPbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001829trophectodermal cell differentiationIEAbiological_process
GO:0035019somatic stem cell maintenanceIEAbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0048733sebaceous gland developmentIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0046983protein dimerization activityIDAmolecular_function
GO:0060598dichotomous subdivision of terminal units involvedIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0021987cerebral cortex developmentIEAbiological_process


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