Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HBA_HUMAN
Description:hemoglobin, alpha 1 [Source:HGNC Symbol;Acc:4823]
Location:chr16 p13.3
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T9SPADKtNVKAAHPRD
S4ADKTHPRD
S53DLSHGsAQVKGGlobinPhosphoSitePlus
T40LSFPTtKTYFPGlobinPhosphoSitePlus
S36ERMFLsFPTTKGlobinPhosphoSitePlus
Y25AHAGEyGAEALGlobinPhosphoSitePlus
T9SPADKtNVKAAGlobinPhosphoSitePlus
S53DLSHGsAQVKGHPRD
T109HCLLVtLAAHLGlobinPhosphoSitePlus
Y25AHAGEyGAEALHPRD; phosphoELM
S139STVLTsKYR__PhosphoSitePlus
Y141VLTSKyR____PhosphoSitePlus
S4__MVLsPADKTPhosphoSitePlus
Y43PTTKTyFPHFDHPRD; phosphoELM
Y43PTTKTyFPHFDGlobinPhosphoSitePlus
T42FPTTKtYFPHFGlobinPhosphoSitePlus

Dephosphorylation site
HBA_HUMAN do not have dephosphorylation site.

Mutation site
HBA_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000322421hepatitis B virusNormal vs. CancertissueUp3.414726492
ENSP00000322421Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000322421Hepatocellular CarcinomaNormal vs. CancertissueDown0.2717627933
ENSP00000322421Oral CancerNormal vs. CancertissueDown0.1319691830
ENSP00000322421Pancreatic CancerNormal vs. CancertissueDown0.3216230073

Hyperphosphorylation site
HBA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANHBA_HUMANTF -> target geneTRANSFAC
NFIC_HUMANHBA_HUMANTF -> target geneTRANSFAC
Q15552_HUMANHBA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
HBA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005506iron ion bindingIEAmolecular_function
GO:0015671oxygen transportTASbiological_process
GO:0015701bicarbonate transportTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0004601peroxidase activityIDAmolecular_function
GO:0005344oxygen transporter activityIEAmolecular_function
GO:0031720haptoglobin bindingIDAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0019825oxygen bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0010942positive regulation of cell deathIDAbiological_process
GO:0051291protein heterooligomerizationIDAbiological_process
GO:0022627cytosolic small ribosomal subunitIDAcellular_component
GO:0031838haptoglobin-hemoglobin complexIDAcellular_component
GO:0042542response to hydrogen peroxideIDAbiological_process
GO:0042744hydrogen peroxide catabolic processIDAbiological_process
GO:0020037heme bindingIEAmolecular_function
GO:0005833hemoglobin complexIEAcellular_component


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