Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TERT_HUMAN
Description:telomerase reverse transcriptase [Source:HGNC Symbol;Acc:11730]
Location:chr5 p15.33
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y707PPPELyFVKVDSRCHPRD; phosphoELM; RegPhos
Y707PPPELyFVKVDSrcRegPhos
T1101LRTAQtQLSRKRegPhos
Y122TSVRSyLPNTVPhosphoSitePlus
Y707PPPELyFVKVDRVT_1PhosphoSitePlus
S134DALRGsGAWGLPhosphoSitePlus
S797IEQSSsLNEASphosphoELM; RegPhos
S824RIRGKsYVQCQAKT1RegPhos
T26VLPLAtFVRRLPhosphoSitePlus
Y949SDYSSyARTSIPhosphoSitePlus
S227RRRGGsASRSLPhosphoSitePlus
S227RRRGGsASRSLAKT1HPRD; RegPhos
S227RRRGGsASRSLAKT_groupRegPhos
S824RIRGKsYVQCQPKB_groupphosphoELM
S948QSDYSsYARTSPhosphoSitePlus
S824RIRGKsYVQCQRVT_1PhosphoSitePlus
T1113PGTTLtALEAAPhosphoSitePlus; phosphoELM; RegPhos
T767HVSTLtDLQPYRVT_1PhosphoSitePlus
S227RRRGGsASRSLPKB_groupphosphoELM
S824RIRGKsYVQCQAKT_groupRegPhos
S1125NPALPsDFKTIPhosphoSitePlus; phosphoELM; RegPhos

Dephosphorylation site
TERT_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309572Y717NCOSMICHead and Neck Cancer21798893
ENSP00000309572Y717NCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000309572Breast CancerNormal vs. CancertissueUp18257521

Hyperphosphorylation site
TERT_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRC_HUMANTERT_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANTERT_HUMANkinase -> substrateRegPhos
AKT1_HUMANTERT_HUMANkinase -> substrateRegPhos; NetPath
SP1_HUMANTERT_HUMANTF -> target geneTRANSFAC
MYC_HUMANTERT_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05166HTLV-I infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003720telomerase activityIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007004telomere maintenance via telomeraseIMPbiological_process
GO:0016605PML bodyIDAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005730nucleolusIEAcellular_component
GO:0000723telomere maintenanceTASbiological_process
GO:0032203telomere formation via telomeraseIDAbiological_process
GO:0005697telomerase holoenzyme complexIDAcellular_component
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005654nucleoplasmIDAcellular_component
GO:0003964RNA-directed DNA polymerase activityIEAmolecular_function
GO:0006278RNA-dependent DNA replicationIEAbiological_process
GO:0022616DNA strand elongationIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0070034telomeric RNA bindingIDAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0003721telomeric template RNA reverse transcriptase activTASmolecular_function
GO:0000783nuclear telomere cap complexICcellular_component
GO:0003720telomerase activityIEAmolecular_function
GO:0000781chromosome, telomeric regionICcellular_component
GO:0042162telomeric DNA bindingTASmolecular_function
GO:0090399replicative senescenceIMPbiological_process