Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CO4A1_HUMAN
Description:collagen, type IV, alpha 1 [Source:HGNC Symbol;Acc:2202]
Location:chr13 q34
Node attribute:ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y348KGERGyPGTPGCollagenPhosphoSitePlus
S1012PGPKGsVGGMGCollagenPhosphoSitePlus
S6MGPRLsVWLLLPhosphoSitePlus
S23LHEEHsRAAAKPhosphoSitePlus
T1231SPGHAtEGPKGCollagenPhosphoSitePlus
S1226PGLPGsPGHATCollagenPhosphoSitePlus

Dephosphorylation site
CO4A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364979G636SCOSMICSkin Cancer21984974
ENSP00000364979K757NCOSMICOvarian Cancer21720365
ENSP00000364979P1367SCOSMICOvarian Cancer21720365
ENSP00000364979G1186CCOSMICPancreatic Cancer
ENSP00000364979Q1051LCOSMICOvarian Cancer21720365
ENSP00000364979P120QCOSMICHead and Neck Cancer21984974
ENSP00000364979G794ECOSMICCentral Nervous System Neoplasms18772890
ENSP00000364979D1068YCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000364979Renal CancerNormal vs. CancertissueDown19164279

Hyperphosphorylation site
CO4A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CO4A1_HUMANITB8_HUMANligand -> receptorHPMR
SP1_HUMANCO4A1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04510Focal adhesion
hsa04974Protein digestion and absorption
hsa05146Amoebiasis
hsa04512ECM-receptor interaction
hsa05200Pathways in cancer
hsa05222Small cell lung cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0005581collagenIEAcellular_component
GO:0007411axon guidanceTASbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0005576extracellular regionNAScellular_component
GO:0001525angiogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005587collagen type IVIEAcellular_component
GO:0048407platelet-derived growth factor bindingIDAmolecular_function
GO:0007528neuromuscular junction developmentIEAbiological_process
GO:0030198extracellular matrix organizationTASbiological_process
GO:0031012extracellular matrixISScellular_component
GO:0005201extracellular matrix structural constituentIEAmolecular_function
GO:0071230cellular response to amino acid stimulusIEAbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23