| UniProt/SwissProt ID: | CO4A1_HUMAN |
| Description: | collagen, type IV, alpha 1 [Source:HGNC Symbol;Acc:2202] |
| Location: | chr13 q34 |
| Node attribute: | ligand; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y348 | KGERGyPGTPG | Collagen | PhosphoSitePlus |
| S1012 | PGPKGsVGGMG | Collagen | PhosphoSitePlus |
| S6 | MGPRLsVWLLL | PhosphoSitePlus | |
| S23 | LHEEHsRAAAK | PhosphoSitePlus | |
| T1231 | SPGHAtEGPKG | Collagen | PhosphoSitePlus |
| S1226 | PGLPGsPGHAT | Collagen | PhosphoSitePlus |
| Dephosphorylation site |
| CO4A1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000364979 | G636S | COSMIC | Skin Cancer | 21984974 | ENSP00000364979 | K757N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364979 | P1367S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364979 | G1186C | COSMIC | Pancreatic Cancer | ENSP00000364979 | Q1051L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000364979 | P120Q | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000364979 | G794E | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000364979 | D1068Y | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000364979 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | |
| Hyperphosphorylation site |
| CO4A1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CO4A1_HUMAN | ITB8_HUMAN | ligand -> receptor | HPMR |
| SP1_HUMAN | CO4A1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04510 | Focal adhesion |
| hsa04974 | Protein digestion and absorption |
| hsa05146 | Amoebiasis |
| hsa04512 | ECM-receptor interaction |
| hsa05200 | Pathways in cancer |
| hsa05222 | Small cell lung cancer |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005788 | endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005581 | collagen | IEA | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0005576 | extracellular region | NAS | cellular_component |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005587 | collagen type IV | IEA | cellular_component |
| GO:0048407 | platelet-derived growth factor binding | IDA | molecular_function |
| GO:0007528 | neuromuscular junction development | IEA | biological_process |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |
| GO:0031012 | extracellular matrix | ISS | cellular_component |
| GO:0005201 | extracellular matrix structural constituent | IEA | molecular_function |
| GO:0071230 | cellular response to amino acid stimulus | IEA | biological_process |