Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MIP_HUMAN
Description:major intrinsic protein of lens fiber [Source:HGNC Symbol;Acc:7103]
Location:chr12 q13.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S229FPRLKsISERLPKACaRegPhos
S231RLKSIsERLSVPhosphoSitePlus
S235ISERLsVLKGAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S229FPRLKsISERLPRKACAHPRD
S231RLKSIsERLSVPKACaRegPhos
S245AKPDVsNGQPERegPhos
S229FPRLKsISERLPKA_groupphosphoELM; RegPhos
S231RLKSIsERLSVPKA_groupphosphoELM; RegPhos
S229FPRLKsISERLPhosphoSitePlus
S231RLKSIsERLSVPRKACAHPRD

Dephosphorylation site
MIP_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000257979V125MCOSMICMelanoma21499247

Differential expressed protein
MIP_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MIP_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANMIP_HUMANkinase -> substrateHPRD
ZAGL2_HUMANMIP_HUMANkinase -> substrateRegPhos
SP1_HUMANMIP_HUMANTF -> target geneTRANSFAC
AP2A_HUMANMIP_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
MIP_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006810transportIEAbiological_process
GO:0015250water channel activityIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0050896response to stimulusIEAbiological_process
GO:0005215transporter activityTASmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0015722canalicular bile acid transportIEAbiological_process
GO:0055085transmembrane transportTASbiological_process
GO:0006833water transportIEAbiological_process
GO:0043231intracellular membrane-bounded organelleIEAcellular_component
GO:0005887integral to plasma membraneTAScellular_component
GO:0006833water transportTASbiological_process
GO:0005921gap junctionIEAcellular_component
GO:0005212structural constituent of eye lensIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0046691intracellular canaliculusIEAcellular_component
GO:0007601visual perceptionIEAbiological_process
GO:0002088lens development in camera-type eyeIEAbiological_process


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