| UniProt/SwissProt ID: | MIP_HUMAN |
| Description: | major intrinsic protein of lens fiber [Source:HGNC Symbol;Acc:7103] |
| Location: | chr12 q13.3 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S229 | FPRLKsISERL | PKACa | RegPhos |
| S231 | RLKSIsERLSV | PhosphoSitePlus | |
| S235 | ISERLsVLKGA | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S229 | FPRLKsISERL | PRKACA | HPRD |
| S231 | RLKSIsERLSV | PKACa | RegPhos |
| S245 | AKPDVsNGQPE | RegPhos | |
| S229 | FPRLKsISERL | PKA_group | phosphoELM; RegPhos |
| S231 | RLKSIsERLSV | PKA_group | phosphoELM; RegPhos |
| S229 | FPRLKsISERL | PhosphoSitePlus | |
| S231 | RLKSIsERLSV | PRKACA | HPRD |
| Dephosphorylation site |
| MIP_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000257979 | V125M | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| MIP_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| MIP_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | MIP_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | MIP_HUMAN | kinase -> substrate | RegPhos |
| SP1_HUMAN | MIP_HUMAN | TF -> target gene | TRANSFAC |
| AP2A_HUMAN | MIP_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| MIP_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006810 | transport | IEA | biological_process |
| GO:0015250 | water channel activity | IEA | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0050896 | response to stimulus | IEA | biological_process |
| GO:0005215 | transporter activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0015722 | canalicular bile acid transport | IEA | biological_process |
| GO:0055085 | transmembrane transport | TAS | biological_process |
| GO:0006833 | water transport | IEA | biological_process |
| GO:0043231 | intracellular membrane-bounded organelle | IEA | cellular_component |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0006833 | water transport | TAS | biological_process |
| GO:0005921 | gap junction | IEA | cellular_component |
| GO:0005212 | structural constituent of eye lens | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0046691 | intracellular canaliculus | IEA | cellular_component |
| GO:0007601 | visual perception | IEA | biological_process |
| GO:0002088 | lens development in camera-type eye | IEA | biological_process |