| UniProt/SwissProt ID: | ALDOA_HUMAN |
| Description: | aldolase A, fructose-bisphosphate [Source:HGNC Symbol;Acc:414] |
| Location: | chr16 p11.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y204 | LKRCQyVTEKV | HPRD | |
| Y138 | ERCAQyKKDGA | Glycolytic | PhosphoSitePlus |
| S132 | GLDGLsERCAQ | Glycolytic | PhosphoSitePlus |
| S272 | GITFLsGGQSE | Glycolytic | PhosphoSitePlus |
| S100 | PQVIKsKGGVV | Glycolytic | PhosphoSitePlus |
| T49 | LQSIGtENTEE | Glycolytic | PhosphoSitePlus |
| T235 | KPNMVtPGHAC | HPRD; phosphoELM | |
| S354 | AGAAAsESLFV | HPRD; phosphoELM; SysPTM | |
| S336 | RALANsLACQG | Glycolytic | PhosphoSitePlus |
| S46 | AKRLQsIGTEN | Glycolytic | PhosphoSitePlus; SysPTM |
| S276 | LSGGQsEEEAS | Glycolytic | PhosphoSitePlus |
| T227 | IYLEGtLLKPN | Glycolytic | PhosphoSitePlus |
| T299 | KPWALtFSYGR | Glycolytic | PhosphoSitePlus |
| Y223 | SDHHIyLEGTL | HPRD; phosphoELM | |
| S46 | AKRLQsIGTEN | HPRD; phosphoELM; SysPTM | |
| S17 | QKKELsDIAHR | Glycolytic | PhosphoSitePlus |
| S218 | VYKALsDHHIY | Glycolytic | PhosphoSitePlus |
| T65 | RQLLLtADDRV | Glycolytic | PhosphoSitePlus |
| Y174 | NVLARyASICQ | Glycolytic | PhosphoSitePlus |
| Y3 | ___MPyQYPAL | PhosphoSitePlus | |
| S360 | ESLFVsNHAY_ | Glycolytic | PhosphoSitePlus |
| S17 | QKKELsDIAHR | HPRD | |
| Y5 | ALTP | HPRD; phosphoELM | |
| S39 | DESTGsIAKRL | Glycolytic | PhosphoSitePlus; SysPTM |
| S36 | LAADEsTGSIA | Glycolytic | PhosphoSitePlus; SysPTM |
| Y3 | YPAL | HPRD; phosphoELM | |
| T269 | AVTGItFLSGG | Glycolytic | PhosphoSitePlus |
| T37 | AADEStGSIAK | Glycolytic | PhosphoSitePlus; SysPTM |
| S36 | LAADEsTGSIA | HPRD; SysPTM | |
| S160 | GEHTPsALAIM | Glycolytic | PhosphoSitePlus |
| Y223 | SDHHIyLEGTL | Glycolytic | PhosphoSitePlus |
| T9 | QYPALtPEQKK | PhosphoSitePlus; HPRD | |
| T241 | PGHACtQKFSH | Glycolytic | PhosphoSitePlus |
| T206 | RCQYVtEKVLA | Glycolytic | PhosphoSitePlus |
| T235 | KPNMVtPGHAC | Glycolytic | PhosphoSitePlus |
| Y204 | LKRCQyVTEKV | Glycolytic | PhosphoSitePlus |
| Y364 | VSNHAy_____ | PhosphoSitePlus | |
| S39 | DESTGsIAKRL | HPRD; phosphoELM; SysPTM | |
| Y214 | VLAAVyKALSD | Glycolytic | PhosphoSitePlus |
| T241 | PGHACtQKFSH | HPRD; phosphoELM | |
| Y5 | _MPYQyPALTP | PhosphoSitePlus | |
| S356 | AAASEsLFVSN | Glycolytic | PhosphoSitePlus; SysPTM |
| T65 | RQLLLtADDRV | HPRD; phosphoELM | |
| S356 | AAASEsLFVSN | HPRD; phosphoELM; SysPTM | |
| S301 | WALTFsYGRAL | Glycolytic | PhosphoSitePlus |
| S354 | AGAAAsESLFV | Glycolytic | PhosphoSitePlus; SysPTM |
| T37 | AADEStGSIAK | HPRD; SysPTM | |
| Dephosphorylation site |
| ALDOA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000336927 | R22C | COSMIC | Lung Cancer | ENSP00000455724 | R22C | COSMIC | Lung Cancer | ENSP00000400452 | R22C | COSMIC | Lung Cancer | ENSP00000455700 | R22C | COSMIC | Lung Cancer | ENSP00000455800 | R22C | COSMIC | Lung Cancer | ENSP00000455917 | R22C | COSMIC | Lung Cancer |
| Differential expressed protein |
| ALDOA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ALDOA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | ALDOA_HUMAN | TF -> target gene | TRANSFAC |
| NR2C1_HUMAN | ALDOA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ALDOA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008092 | cytoskeletal protein binding | IDA | molecular_function |
| GO:0070061 | fructose binding | IDA | molecular_function |
| GO:0015629 | actin cytoskeleton | IDA | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0006096 | glycolysis | IEA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0015631 | tubulin binding | TAS | molecular_function |
| GO:0051289 | protein homotetramerization | ISS | biological_process |
| GO:0042802 | identical protein binding | TAS | molecular_function |
| GO:0007015 | actin filament organization | TAS | biological_process |
| GO:0006094 | gluconeogenesis | TAS | biological_process |
| GO:0006754 | ATP biosynthetic process | IMP | biological_process |
| GO:0002576 | platelet degranulation | TAS | biological_process |
| GO:0004332 | fructose-bisphosphate aldolase activity | IEA | molecular_function |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0006006 | glucose metabolic process | TAS | biological_process |
| GO:0008360 | regulation of cell shape | IDA | biological_process |
| GO:0031093 | platelet alpha granule lumen | TAS | cellular_component |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0003779 | actin binding | TAS | molecular_function |
| GO:0031674 | I band | TAS | cellular_component |
| GO:0046716 | muscle cell homeostasis | IMP | biological_process |
| GO:0006941 | striated muscle contraction | IMP | biological_process |
| GO:0006000 | fructose metabolic process | IMP | biological_process |
| GO:0030388 | fructose 1,6-bisphosphate metabolic process | IDA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |