| UniProt/SwissProt ID: | DFFB_HUMAN |
| Description: | DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) [Source:HGNC Symbol;Acc:2773] |
| Location: | chr1 p36.32 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S319 | LNCDPsRIYKP | DFF40 | PhosphoSitePlus |
| Y158 | SGYLRySCESR | DFF40 | PhosphoSitePlus |
| Y322 | DPSRIyKPQTR | DFF40 | PhosphoSitePlus |
| T326 | IYKPQtRLKRK | PhosphoSitePlus | |
| Dephosphorylation site |
| DFFB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000367454 | V178M | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| DFFB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| DFFB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | DFFB_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| DFFB_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0004536 | deoxyribonuclease activity | IEA | molecular_function |
| GO:0006309 | apoptotic DNA fragmentation | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006921 | cellular component disassembly involved in executi | TAS | biological_process |
| GO:0004516 | nicotinate phosphoribosyltransferase activity | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0000790 | nuclear chromatin | IDA | cellular_component |
| GO:0006917 | induction of apoptosis | IEA | biological_process |
| GO:0030263 | apoptotic chromosome condensation | IDA | biological_process |
| GO:0035556 | intracellular signal transduction | TAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0006915 | apoptotic process | TAS | biological_process |