Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DFFB_HUMAN
Description:DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) [Source:HGNC Symbol;Acc:2773]
Location:chr1 p36.32
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S319LNCDPsRIYKPDFF40PhosphoSitePlus
Y158SGYLRySCESRDFF40PhosphoSitePlus
Y322DPSRIyKPQTRDFF40PhosphoSitePlus
T326IYKPQtRLKRKPhosphoSitePlus

Dephosphorylation site
DFFB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367454V178MCOSMICSkin Cancer21984974

Differential expressed protein
DFFB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DFFB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANDFFB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
DFFB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003677DNA bindingIEAmolecular_function
GO:0004536deoxyribonuclease activityIEAmolecular_function
GO:0006309apoptotic DNA fragmentationIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006921cellular component disassembly involved in executiTASbiological_process
GO:0004516nicotinate phosphoribosyltransferase activityIEAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0000790nuclear chromatinIDAcellular_component
GO:0006917induction of apoptosisIEAbiological_process
GO:0030263apoptotic chromosome condensationIDAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0019899enzyme bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0016787hydrolase activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process


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