Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ADA_HUMAN
Description:adenosine deaminase [Source:HGNC Symbol;Acc:186]
Location:chr20 q13.12
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T26SIKPEtILYYGA_deaminasePhosphoSitePlus
S291DQANYsLNTDDA_deaminasePhosphoSitePlus
Y308TLDTDyQMTKRA_deaminasePhosphoSitePlus
T4__MAQtPAFDKPhosphoSitePlus
Y348LLDLLyKAYGMPhosphoSitePlus
Y290NDQANySLNTDA_deaminasePhosphoSitePlus
Y351LLYKAyGMPPSPhosphoSitePlus
Y67LAKFDyYMPAIA_deaminasePhosphoSitePlus
Y249EDQALyNRLRQA_deaminasePhosphoSitePlus
Y84IKRIAyEFVEMA_deaminasePhosphoSitePlus
Y240RLGHGyHTLEDA_deaminasePhosphoSitePlus
S358MPPSAsAGQNLPhosphoSitePlus
Y29PETILyYGRRRA_deaminasePhosphoSitePlus
Y30ETILYyGRRRGA_deaminasePhosphoSitePlus

Dephosphorylation site
ADA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361965R142QHPIpancreatic ductal adenocarcinoma8589684 18772397 17181544 11067872

Differential expressed protein
ADA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ADA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LEF1_HUMANADA_HUMANTF -> target geneTRANSFAC
P73_HUMANADA_HUMANTF -> target geneTRANSFAC
SP1_HUMANADA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ADA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007568agingIEAbiological_process
GO:0010460positive regulation of heart rateIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005764lysosomeIDAcellular_component
GO:0045187regulation of circadian sleep/wake cycle, sleepIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0046101hypoxanthine biosynthetic processIEAbiological_process
GO:0033632regulation of cell-cell adhesion mediated by integIDAbiological_process
GO:0050862positive regulation of T cell receptor signaling pIEAbiological_process
GO:0001821histamine secretionIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0070256negative regulation of mucus secretionIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0070244negative regulation of thymocyte apoptotic processIEAbiological_process
GO:0016020membraneIDAcellular_component
GO:0060169negative regulation of adenosine receptor signalinIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046103inosine biosynthetic processIEAbiological_process
GO:0046061dATP catabolic processIEAbiological_process
GO:0004000adenosine deaminase activityISSmolecular_function
GO:0048541Peyer's patch developmentIEAbiological_process
GO:0006154adenosine catabolic processIEAbiological_process
GO:0002906negative regulation of mature B cell apoptotic proIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0002636positive regulation of germinal center formationIEAbiological_process
GO:0042323negative regulation of circadian sleep/wake cycle,IEAbiological_process
GO:0048286lung alveolus developmentIEAbiological_process
GO:0006157deoxyadenosine catabolic processIEAbiological_process
GO:0043101purine-containing compound salvageTASbiological_process
GO:0050850positive regulation of calcium-mediated signalingIEAbiological_process
GO:0045582positive regulation of T cell differentiationIEAbiological_process
GO:0048566embryonic digestive tract developmentIEAbiological_process
GO:0004000adenosine deaminase activityIEAmolecular_function
GO:0002686negative regulation of leukocyte migrationIEAbiological_process
GO:0006154adenosine catabolic processISSbiological_process
GO:0050728negative regulation of inflammatory responseIEAbiological_process
GO:0001889liver developmentIEAbiological_process
GO:0032839dendrite cytoplasmIEAcellular_component
GO:0001890placenta developmentIEAbiological_process
GO:0033089positive regulation of T cell differentiation in tIEAbiological_process
GO:0001666response to hypoxiaIDAbiological_process
GO:0043278response to morphineIEAbiological_process
GO:0019239deaminase activityIEAmolecular_function
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0002314germinal center B cell differentiationIEAbiological_process
GO:0046103inosine biosynthetic processISSbiological_process
GO:0043103hypoxanthine salvageIBAbiological_process
GO:0045580regulation of T cell differentiationIEAbiological_process
GO:0060407negative regulation of penile erectionIEAbiological_process
GO:0008270zinc ion bindingISSmolecular_function
GO:0009897external side of plasma membraneIDAcellular_component
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0050870positive regulation of T cell activationIEAbiological_process
GO:0046638positive regulation of alpha-beta T cell differentIEAbiological_process
GO:0009168purine ribonucleoside monophosphate biosynthetic pIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0042110T cell activationIDAbiological_process
GO:0060205cytoplasmic membrane-bounded vesicle lumenIEAcellular_component
GO:0006144purine nucleobase metabolic processTASbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0032261purine nucleotide salvageIMPbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0055086nucleobase-containing small molecule metabolic proTASbiological_process
GO:0046111xanthine biosynthetic processIEAbiological_process
GO:0001883purine nucleoside bindingIEAmolecular_function
GO:0045987positive regulation of smooth muscle contractionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0001829trophectodermal cell differentiationIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process