Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOS1_HUMAN
Description:nitric oxide synthase 1 (neuronal) [Source:HGNC Symbol;Acc:7872]
Location:chr12 q24.22
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y609CDNSRyNILEENO_synthasePhosphoSitePlus
S1417RLRSEsIAFIEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S852KVRFNsVSSYSPKC_groupRegPhos
S1378QQGKLsAEDAGPhosphoSitePlus
S852KVRFNsVSSYSPKCaRegPhos
S852KVRFNsVSSYSCaMK2aRegPhos
T1358VCGDVtMAADVNAD_binding_1PhosphoSitePlus
S746EAVKFsAKLMGCAMK1HPRD
S852KVRFNsVSSYSCaMK1aRegPhos
T766TILYAtETGKSFlavodoxin_1PhosphoSitePlus
S852KVRFNsVSSYSFlavodoxin_1PhosphoSitePlus
S852KVRFNsVSSYSPRKCAHPRD
S852KVRFNsVSSYSCaM-KII_alphaphosphoELM
T768LYATEtGKSQAFlavodoxin_1PhosphoSitePlus
S852KVRFNsVSSYSPRKACAHPRD
T396KEIDTtSTYQLHPRD
S852KVRFNsVSSYSPKACaRegPhos
S852KVRFNsVSSYSPKA_groupRegPhos
S852KVRFNsVSSYSCaMK4RegPhos
S1387AGVFIsRMRDDPhosphoSitePlus
T724HVWKGtNGTPTPhosphoSitePlus
S852KVRFNsVSSYSCAMK2AHPRD
S397EIDTTsTYQLKNO_synthasePhosphoSitePlus
T395NKEIDtTSTYQNO_synthasePhosphoSitePlus
S852KVRFNsVSSYSCAMK4HPRD
S852KVRFNsVSSYSCAMK1HPRD
Y453CNHVKyATNKGNO_synthasePhosphoSitePlus

Dephosphorylation site
NOS1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000320758E795QBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000320758D1362NCOSMICOvarian Cancer20826764
ENSP00000320758T439MCOSMICCentral Nervous System Neoplasms21817013
ENSP00000320758L252VCOSMICHead and Neck Cancer21798893
ENSP00000320758S771LCOSMICMelanoma21499247
ENSP00000320758G289ECOSMICMelanoma21499247
ENSP00000320758T1315MCOSMICHead and Neck Cancer21798893
ENSP00000320758P1186TCOSMICOvarian Cancer21720365
ENSP00000320758E333DCOSMICOvarian Cancer21720365
ENSP00000320758R48CCOSMICPancreatic Cancer
ENSP00000320758P570SCOSMICSkin Cancer21984974

Differential expressed protein
NOS1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NOS1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KCC4_HUMANNOS1_HUMANkinase -> substrateHPRD
KCC2A_HUMANNOS1_HUMANkinase -> substrateHPRD
KCC1A_HUMANNOS1_HUMANkinase -> substrateHPRD
ZAGL2_HUMANNOS1_HUMANkinase -> substrateRegPhos
KPCA_HUMANNOS1_HUMANkinase -> substrateHPRD
SP1_HUMANNOS1_HUMANTF -> target geneTRANSFAC
SP3_HUMANNOS1_HUMANTF -> target geneTRANSFAC
MZF1_HUMANNOS1_HUMANTF -> target geneTRANSFAC
SP2_HUMANNOS1_HUMANTF -> target geneTRANSFAC
ZNF76_HUMANNOS1_HUMANTF -> target geneTRANSFAC
ZN143_HUMANNOS1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa04970Salivary secretion
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04020Calcium signaling pathway
hsa04730Long-term depression
hsa00330Arginine and proline metabolism
hsa04145Phagosome
hsa05010Alzheimer's disease

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010523negative regulation of calcium ion transport into TASbiological_process
GO:0009408response to heatIDAbiological_process
GO:0045776negative regulation of blood pressureIBAbiological_process
GO:0001666response to hypoxiaIEPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005737cytoplasmTAScellular_component
GO:0006809nitric oxide biosynthetic processIBAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0043197dendritic spineIEAcellular_component
GO:0050661NADP bindingISSmolecular_function
GO:0004517nitric-oxide synthase activityISSmolecular_function
GO:0006809nitric oxide biosynthetic processIEAbiological_process
GO:0034618arginine bindingTASmolecular_function
GO:0051701interaction with hostTASbiological_process
GO:0016529sarcoplasmic reticulumIDAcellular_component
GO:0005856cytoskeletonIEAcellular_component
GO:0042383sarcolemmaIDAcellular_component
GO:0004517nitric-oxide synthase activityIEAmolecular_function
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0006527arginine catabolic processICbiological_process
GO:0005506iron ion bindingIEAmolecular_function
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0010181FMN bindingISSmolecular_function
GO:0001917photoreceptor inner segmentISScellular_component
GO:0020037heme bindingISSmolecular_function
GO:0043267negative regulation of potassium ion transportIEAbiological_process
GO:0007263nitric oxide mediated signal transductionIBAbiological_process
GO:0045202synapseIEAcellular_component
GO:0035066positive regulation of histone acetylationIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0051346negative regulation of hydrolase activityIEAbiological_process
GO:0090382phagosome maturationTASbiological_process
GO:0005856cytoskeletonISScellular_component
GO:0042383sarcolemmaIEAcellular_component
GO:0033555multicellular organismal response to stressIMPbiological_process
GO:0007520myoblast fusionTASbiological_process
GO:0031284positive regulation of guanylate cyclase activityIBAbiological_process
GO:0016491oxidoreductase activityIBAmolecular_function
GO:0003958NADPH-hemoprotein reductase activityIBAmolecular_function
GO:0055117regulation of cardiac muscle contractionTASbiological_process
GO:0042738exogenous drug catabolic processIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0048471perinuclear region of cytoplasmISScellular_component
GO:0046870cadmium ion bindingISSmolecular_function
GO:0006941striated muscle contractionIEAbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0051612negative regulation of serotonin uptakeIEAbiological_process
GO:0045909positive regulation of vasodilationIDAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0034617tetrahydrobiopterin bindingNASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0018119peptidyl-cysteine S-nitrosylationIEAbiological_process
GO:0051926negative regulation of calcium ion transportIEAbiological_process
GO:0042136neurotransmitter biosynthetic processTASbiological_process
GO:0050660flavin adenine dinucleotide bindingISSmolecular_function